Objective To explore the effects and mechanism of electroacupuncture and Jiawei Shaoyao Gancao (Supplemented Peony and Licorice) Decoction to alleviate spasticity of cerebral apoplexy (SC A)・ Methods Qualified SD rats were selected to form into the blank group, sham operation group, model group, electroacupuncture group, Jiawei Shaoyao Gancao (JSG) Decoction group, electroacupuncture + JSG group, and baclofen group (北二 9)・ The improved Zeathread method and internal capsule injection of the NMDA receptor method were used to prepare a stroke rat model with limb spasticity・ After the successful modelling was confirmed with behavioral score, the following interventions were performed for each group for five days: electroacupuncture group (bilateral GB 34 (Yanglingquan) and LI 11 (Quchi), 30 min per time, once a day), JSG Decoction group (decoction, 10 mL/kg, once a time), baclofen group (baclofen tablet aqueous solution, 10 mL/kg, once a time), electroacupuncture + JSG group (the combination of the corresponding interventions in JSG decoction group and electroacupuncture group)・ Behavioral detection of nerve damage and electron microscope observation of synaptic neuron ultrastructure were applied after intervention; Besides, reverse transcription-polymerase chain reaction detection and Western blotting were used to detect the expression of BDNF, Trkb, SYN, PSD95 related mRNA and protein expressions in the cortex・ Results Compared with the normal group, the Zealonga neurological function score of the model group was increased (P<0・01); the number of synapses under the microscope was significantly reduced, the number of vesicles was reduced and the density was uneven, the front and back membranes and spaces were fused with blurred boundaries; the postsy nap tic terminal cytoplasmic degeneration and solubilization of the cells were significant, the density of the post-synaptic compact zone also decreased, and the mRNA and protein expression levels of BDNF, Trkb, SYN, PSD95 were decreased (P < 0.01). Compared with the model group, the scores of each treatment group were decreased (P < 0. 05), the synaptic structure of each treatment group was significantly relieved, and the mRNA and protein expression levels of BDNF, Trkb, SYN, and PSD95 were increased (P <0. 05, P <0. 01); there was no significant difference in the scores among the treatment groups (P >0.05). The synaptic cell vesicles in the electroacupuncture + JSG group were clearly formed, with clear boundaries and regular gaps・ In both the electroacupuncture + JSG group and baclofen group, the mRNA and protein expressions of BDNF, Trkb, SYN and PSD95 were significantly increased (P <0. 05, P<0・01)・ Conclusion Electroacupuncture combined with Jiawei Shaoyao Gancao (JSG) Decoction seems to down regulate the expression of neurotrophic factors (BDNF, TrkB) and synaptic plasticity related proteins (syn, PSD95) in SCA rats, so as to regulate the recovery of spasticity after stroke to a greater extent. [ABSTRACT FROM AUTHOR]