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Bulimia nervosa is a type of eating disorders characterized by recurrent binge eating and compensatory behaviors to prevent weight gain, as well as excessive concern about body shape and mass. The patients with bulimia nervosa present with disturbed eating behavior, resulting in electrolyte abnormalities, gastrointestinal disorders, metabolic and endocrine disorders and other physical problems; secondly, the bulimia nervosa patients are often co-morbid with a variety of mental disorders such as bipolar disorder, depression, substance use disorders, which need to be taken seriously. However, bulimia nervosa and even eating disorders cannot be recognized and diagnosed at an early stage in China, which leads to a prolonged course of the disease. Therefore, under the organization of the Eating Disorders Coordination Group of the Psychosomatic Medicine Society of the Chinese Medical Association, in conjunction with the Eating Disorders Research Collaboration Group of the Psychiatric Medicine Society of the Chinese Medical Association, this expert consensus was formulated by 12 experts in the field of psychiatry and evidence-based medicine based on evidence-based medicine, domestic and foreign guidelines and expert consensus and expert experience, in order to improve the recognition, diagnosis and treatment of bulimia nervosa by psychiatric professionals and general practitioners in China.

As a member of the nuclear receptor subfamily, NR4A1 works with glycerol kinase, a key glucose and lipid metabolism enzyme, to lower blood glucose and boost blood lipids and maintain glucose and lipid homeostasis, while NR4A1 deficiency leads to disruption of hepatic glucose and lipid metabolism. NR4A1 is involved in maintaining the dynamic balance of oxide and antioxidants, reducing inflammatory responses, and promoting autophagy, among other activities. Since NR4A1 is closely related to the occurrence of diabetic nephropathy and other diseases,it has aroused widespread concern in recent years.

Vitiligo is a common skin disease with acquired depigmentation, seriously impacting patients′ physical and mental health. With the acceleration of life rhythm and the increase in psychological stress, the incidence of vitiligo increases. Because of the complicated pathogenesis, the treatment of vitiligo is still one of the most difficult challenges in dermatology. At present, the therapeutic efficacy for vitiligo is limited although various treatment methods are available. Therefore, new therapeutic approaches still need to be explored. Psoralea corylifolia injection, a proprietary Chinese medicine, can stimulate the synthesis and transport of melanin, and promote the division and proliferation of surviving melanocytes in the epidermis and hair follicles. Hence, the Psoralea corylifolia injection-based combination therapy is expected to provide a new safe and effective treatment for vitiligo. In this paper, we review literature on Psoralea corylifolia injection for vitiligo in respect of the mechanisms, usage and adverse reactions.

In this study, soybean protein isolate (SPI) and blueberry anthocyanins (BANs) complex (HPPM-SPI-BANs) treated by high power pulsed microwave (HPPM) was prepared, and its physicochemical properties and biological activity were evaluated. The effect of HPPM treatment on the functional properties and biological activity of SPI was studied. In addition, the effect of partial replacement of egg white protein by HPPM-SPI-BANs on the baking quality and storage properties of cake was evaluated. The results indicated that HPPM treatment significantly improved the solubility of HPPM-SPI-BANs by 2.11 folds, and improved the foaming and emulsifying properties (P < 0.05). The antioxidant activity was also significantly improved compared with SPI and SPI-BANs complex without HPPM treatment. Moreover, the addition of HPPM-SPI-BANs inhibited water loss during cake baking and improved the hardness and chewiness of cake. The 2,2-diphenyl-1-picryhydrazyl (DPPH) radical scavenging activity and ferric reducing antioxidant power of cake with HPPM-SPI-BANs increased by 4.56 and 3.79 folds, respectively, and the aging rate constant k decreased to 0.12. Accordingly, HPPM-SPI-BANs plays an important role in improving the shelf life quality of cake.

In order to study the deformation and failure mechanism of the roof in end slope mining, a mechanical model of the two-end fixed beam was established, combined with the theory of elasticity to derive the calculation equations for the stress and displacement of the roof, and to consider the effect of the extrusion of the overlying weak rock layer of the rib pillar on the deformation of the roof, and finally, the analysis obtained the stress distribution and deformation law of the roof. The research shows that the distribution of normal stresses in the roof is parabolic with a secondary axisymmetric distribution at the center of the roadway, and the maximum tensile stress is at the center of the bottom of the roadway. The maximum tensile stress and the maximum shear stress on the roof increase continuously with the increase of mining progress. The location of the middle of the bottom surface of the roof first shows tensile failure, and then gradually changes to shear failure at the contact location with the coal pillars. The value of u at the bottom of the roof rock beam shows a trend of first decreasing, then increasing, and finally decreasing as x increases, but lateral extrusion has little effect on the horizontal displacement of the roof. The displacement component ν of the roof shows a parabolic variation law with x opening upward. The absolute value of displacement |ν| considering the simultaneous action of vertical compression and lateral extrusion is the most obvious.

Effects of liquid polybutadiene rubber activity-50 on the processability and fatigue resistance of cis-1,4-polybutadiene rubber (BR)/natural rubber (NR) blends were investigated. The fatigue resistance of vulcanizates was investigated from the perspective of fatigue crack propagation using crack growth test platform and finite element ABAQUS/CAE. The results showed that activity-50 could reduce the storage modulus and viscosity of the rubber blend, and the addition of activity-50 in the rubber blending process could improve the processability of the system. Adding 2 phr and 4 phr of active-50 could reduce the crack growth rate. When the amount of active-50 continued to increase, the crack would accelerate. Adding an appropriate amount of activity-50 could improve the processability and fatigue resistance of BR/NR blend.

In order to improve the accuracy of stiffness calculation and derive an accurate rotation angle function and a more accurate deflection function, bu using the chain rule, considering all the higher-order quantities, and combining the relations of higher-order quantities and geometric characteristics, the rotation angle function of the beam was accurately deduced, and the reason for the error of the traditional approximation method was revealed. Consequently a more accurate deflection function was obtained by using the precise rotation angle function. To further verify the reliability of the precise functions, simulation was performed by the method of finite elements. The results show that the value of the angle of rotation obtained by the precise rotation angle function satisfied the finite element simulation results. The accurate rotation angle function was more in line with the actual angle of the beam and was more suitable for practical engineering, which provides a theoretical basis for further approach of the precise deflection function. The calculation result of the accurate rotation angle function can be obtained quickly by related software, which could promote the update of the related software's solution method, and have a wide application prospect.

To improve the accuracy of the modeling and stability evaluation of the waste dump, the theoretical analysis is conducted on the remolding load produced by different operation modes of the waste dump. Combined with the compressive deformation characteristics of pore structure, the growth mechanism of shear strength of rock and soil in the remolding process is revealed. Based on the actual production of Shengli Open-pit Mine, this paper puts forward the method of inclined stratification of internal waste dump and horizontal stratification of external waste dump, and analyzes the influence of stratum division on the evaluation result of waste dump stability. The results show that the stability coefficients of the internal and external waste dumps are 6.2% and 30% higher than those of the traditional waste dumps, respectively, and the difference of stratum mechanical parameters results in the overall upward migration of the potentially dangerous slide surface.

In order to make full use of the difference of seasonal freeze-thaw strength of the soil on the free face of the slope to improve the recovery rate of the coal under the end-slope, the mechanism of the improvement of the shear strength of the frozen soil is analyzed by using shear plane microstructure model. Two kinds of strips mining methods for the secondary steep mining in the freezing period are proposed, and the optimal strips width analysis flow is designed. A case study on the south end-slope of Western Shengli No.1 open-pit mine is carried out. The results show that the stability factors of the south end-slope in the non freezing period and freezing period are 1.06 and 1.14, respectively. The second steep mining can be carried out in the freezing period, and the optimal strips width is determined to be 60 m by analysis. The secondary steep mining realized that the south end-slope angle was raised from 30° to 33° and the end-slope residual coal was recovered by 171 500 t. In the seasonal frozen soil area, the implementation of the strips secondary steep mining can ensure the safety of the slope and further improve the recovery rate of resources.

In order to study the stability difference of dump slope under different pore water pressure redistribution and evaluate the stability, according to the actual groundwater level distribution of a mine dump from August to September, the influence mechanism of water pressure redistribution on slope stability is analyzed. SLOPE/W module is used to simulate the slope stability difference and safety factor variation under different pore water pressure distribution. The results show that the redistribution of pore water pressure will change the pore space in the slope, accelerate the infiltration, and weaken the slope of waste dump in different degrees. With the decrease and expansion of the negative pore water pressure distribution range, the matrix suction of the slope changes and the safety factor first decreases and then increases. When the slope safety factor increases to 1.421, the groundwater level decreases by 30 m. It is close to the basement as a whole and will no longer affect the slope stability of waste dump.