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Progress in the role of NR4A1 in the development of diabetic nephropathy
- Source :
- Jichu yixue yu linchuang, Vol 43, Iss 10, Pp 1608-1611 (2023)
- Publication Year :
- 2023
- Publisher :
- Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College., 2023.
-
Abstract
- As a member of the nuclear receptor subfamily, NR4A1 works with glycerol kinase, a key glucose and lipid metabolism enzyme, to lower blood glucose and boost blood lipids and maintain glucose and lipid homeostasis, while NR4A1 deficiency leads to disruption of hepatic glucose and lipid metabolism. NR4A1 is involved in maintaining the dynamic balance of oxide and antioxidants, reducing inflammatory responses, and promoting autophagy, among other activities. Since NR4A1 is closely related to the occurrence of diabetic nephropathy and other diseases,it has aroused widespread concern in recent years.
- Subjects :
- nr4a1
diabetic nephropathy
Medicine
Subjects
Details
- Language :
- Chinese
- ISSN :
- 10016325
- Volume :
- 43
- Issue :
- 10
- Database :
- Directory of Open Access Journals
- Journal :
- Jichu yixue yu linchuang
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.971860a93984445b848db50899d21a32
- Document Type :
- article
- Full Text :
- https://doi.org/10.16352/j.issn.1001-6325.2023.10.1608