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目的本研究旨在改进生殖男科领域现有的精液处理方法，特别是针对双层密度梯度法中的300 ×g 20 min处理条件，以提高受精结局。方法收集2020年7月和9月以及2022年3月和5月在中山大学附属第六医院生殖医学中心进行辅助生殖助孕的1 623例患者的精液标本进行实验。预实验中，比较四种不同的双层密度梯度方法（200 ×g 10 min、200 ×g 20 min、300 ×g 10 min和300 ×g 20 min）处理后标本的精子DNA碎片率和回收率。然后，筛选出一种最优的方法作为新方法，并与目前在用的旧方法（300 ×g 20 min双层梯度法）进行对比，检验受精率是否有统计学差异。在新方法的基础上，进一步优化为单层密度梯度法，并与双层密度梯度法进行对比，检验是否存在统计学差异。实验过程中严格控制温度、离心速度和离心时间，同时记录每组样本的数量和处理条件。结果在保证足够的精子回收率的基础上，发现四种双层密度梯度法中300 ×g 10 min的精子DNA碎片率低于300 ×g 20 min。因此，选择300 ×g 10 min作为新方法进行试验。结果表明，新方法300 ×g 10 min的总受精率、二核体（2pn）受精率均高于300 ×g 20 min，且差异有统计学意义（Pg 10 min的卵裂率也略高于300 ×g 20 min，但差异没有统计学意义（P>0.05）。单层密度梯度法的总受精率、2pn受精率均高于双层密度梯度法，但差异没有统计学意义（P>0.05）；单层密度梯度法的卵裂率高于双层密度梯度法，囊胚形成率低于双层密度梯度法，且差异均有统计学意义（Pg 20 min双层梯度法，300 ×g 10 min双层梯度法成功提高了总受精率、2pn受精率、卵裂率，缩短了精液优化处理的时间；而单层密度梯度法虽提高了卵裂率、节约了试剂成本和操作时间，但其囊胚形成率却出现了下降的情况。这些发现为生殖男科领域的精液处理方法提供了有益的指导和启示。

This paper summarized the nursing management for a patient with intertrochanteric fracture combined with pressure injuries in the left buttocks. Effective treatment plan was made based on the nursing evaluation of stage of pressure injuries. Wound dressing material and dressing change methods were carefully considered according to the different phases of wound healing. Targeted nursing interventions were carried out to improve the wound healing of the patient with pressure injuries. (本文总结1例股骨粗隆间骨折合并左臀部压力性损伤的护理经验。正确评估压力性损伤的等级, 给予有效的治疗措施, 并根据患者创面的变化, 选取适合的换药方式, 应用正确的创面敷料, 有针对性地进行护理干预, 有助于促进压力性损伤的愈合。)

目的比较单精子冷冻和常规冷冻对显微取精患者的胚胎培养及妊娠影响。方法回顾性分析自2018年1月至2021年12月于中山大学附属第六医院生殖医学研究中心行显微镜取精术患者的临床资料，行单精子冷冻共39例307枚成熟卵子为单精子冷冻组，通过SPSS统计软件倾向性评分匹配女方基本助孕信息1：1匹配选择对照组，为常规冷冻组，共410枚成熟卵子，分析单精子冷冻与常规冷冻两组的受精、胚胎培养及移植后妊娠情况。结果单精子冷冻组和常规冷冻组的年龄、体质量指数（BMI）、不孕年限、基础基础卵泡刺激素（FSH）、基础黄体生成素（LH）、基础雌二醇（E2）、抗苗勒管激素（AMH）、窦卵泡计数（AFC）、获卵数、移植胚胎数等一般资料的比较，差异均差异无统计学意义（P>0.05）；两组的受精率、可利用胚胎率、优质胚胎率比较分别为65.8% vs. 60.49%、67.82% vs. 58.87%、70.80% vs. 75.34%，差异均无统计学意义；两组的临床妊娠率为45.45% vs. 70.0%，有统计学差异（P=0.049）。结论显微取精患者若获取精子极少，为增加每颗精子利用机会以及保证后续助孕精子解冻后获取精子，单精子冷冻可为有效选择，但临床妊娠率下降，因例数限制，对后续妊娠的影响还需增加例数再观察分析。

At present, the model of Internet Plus continuity of care ensures that patients receive continuous and effective care interventions in the family and community, thereby improving their quality of life and accelerating the recovery process. This paper analyzed and summarized the application of continuity of care based o Internet Plus model in patients after total hip arthroplasty, in order to provide reference for healthcare professionals to provide multifaceted care for patients after surgery. (人工髋关节置换术后患者出院后的居家康复管理是加快术后康复的关键。“互联网+延续性护理”模式可确保患者在家庭和社区中得到持续有效的护理干预, 从而提高其生活质量, 加速康复进程。本文就“互联网+延续性护理”模式在髋关节置换术后患者中的应用进行分析和总结, 旨在为髋关节置换术后患者的康复治疗提供参考。)

目的探索人卵泡液中神经营养因子4（NT-4）及卵丘颗粒细胞中TrkB受体的表达与卵子发育潜能的关系。方法收集2020年5月至2020年11月在中山大学附属第六医院生殖中心，因男方因素行卵胞浆内单精子注射（ICSI）治疗的63例患者的卵泡液和卵丘颗粒细胞，用ELISA检测卵泡液中NT-4水平，实时荧光定量PCR检测卵丘颗粒细胞中TrkB受体两种不同亚型TrkB-fl和TrkB-t1的表达水平，分析与卵子成熟、受精和胚胎发育的关系。结果卵泡液中NT-4水平与正常受精数（rs=0.250， P=0.048）、可利用胚胎数（rs=0.320， P=0.011）、优质胚胎数（rs=0.327， P=0.009）和优质囊胚数（rs=0.303， P=0.029）呈正相关。卵丘颗粒细胞中TrkB-t1在高囊胚形成率组（≥60%）和高优质囊胚率组（≥50%）中的表达均较低［0.86 （0.60， 1.85） vs. 2.29 （1.09， 3.44） ， P=0.008； 0.84（0.64， 1.45） vs. 1.73 （0.96， 3.14） ， P=0.031］。多重线性回归分析结果示优质胚胎数受获卵数（P=0.001）、卵泡液中NT-4水平（P=0.005）和卵丘颗粒细胞TrkB-t1表达水平（P=0.049）影响。结论人卵泡液中NT-4水平与ICSI患者卵子发育潜能正相关，其可能在卵子发育过程中发挥着重要作用。卵丘颗粒细胞中TrkB-t1的高表达与卵子发育潜能受损有关。

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Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Ischemic stroke is a common acute cerebrovascular disease in clinical practice, which poses a severe threat to human health. In recent years, with deepening understanding of ischemic stroke, significant progress has been made in the diagnosis and treatment. However, current treatments for ischemic stroke are partially limited due to extremely complex pathological mechanisms. Studies have shown that mitochondrial dysfunction plays an important role in the pathogenesis of ischemic stroke. Therefore, modulation of mitochondrial function through mitochondrial dynamics is essential to ameliorate the damage of cerebral ischemic neuronal cells. In this article, the molecular mechanism of mitochondrial dynamics and its role in ischemic stroke were reviewed, aiming to provide useful reference for the treatment of ischemic stroke. [ABSTRACT FROM AUTHOR]

目的探讨体外受精（IVF）周期获卵≤3枚胚胎移植策略。方法回顾性分析2017年1月至2019年4月于中山大学附属第六医院生殖医学研究中心行IVF/ICSI助孕患者共1 600个周期，分为3组：1组：新鲜周期D3移植（615例），2组：复苏周期D3移植（525例），3组：复苏周期囊胚移植（460例），收集3组患者助孕资料，多因素回归分析比较3组间的生化妊娠、临床妊娠及活产情况。结果3组患者年龄、基础FSH、AMH无明显差别，t检验结果均P>0.05，即两组数据总体一般资料无差异。1组与2组相比，1组有更高的生化妊娠率、临床妊娠率及活产率（38.2% vs. 29.3%，34.5% vs. 25.9%，18.2% vs. 11.2%）,差异有统计学意义。若患者因各种原因取消移植，复苏周期的囊胚移植（3组），生化妊娠率、临床妊娠率及活产率明显高于2组（36.7% vs. 29.3%，33.4% vs. 25.9%，13.7% vs. 11.2%）, 差异有统计学意义。通过多因素回归分析，在控制了年龄、AMH、胚胎移植等级等潜在混杂因素后，1组的活产率仍显著高于2组[OR=1.906 (1.272-2.857)，P=0.002]，3组的活产率仍显著高于2组[OR=3.388 (1.876-6.118)，P=0.000]。结论IVF周期中，若患者获卵≤3枚，争取新鲜周期D3移植；若取消移植，全胚冷冻建议囊胚冷冻。

Household electric vehicle charging in residential areas has a strong centrality. Large-scale electric vehicle charging load causes large peak valley load difference and other problems in the distribution network system. This study proposes a user charging selection control strategy based on Multi Objective Particle Swarm Optimization (MPSO) algorithm. Through the analysis and prediction of electric vehicle charging load, a multi-objective optimization model is established with the minimum variance of the total system load and scheduling cost as the objective function. Meanwhile, considering the constraints of electric vehicle battery and system power, the MPSO algorithm is used to solve the optimal initial charging time of electric vehicles. The simulation results show that compared with unordered charging of EVs in residential areas, the EV charging strategy proposed in this study can effectively reduce load peak and dispatch cost. [ABSTRACT FROM AUTHOR]

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Objective To explore the effects and mechanism of methylglyoxal (MGO) in human brain microvascular endothelial cell line (hCMEC/D3). Methods The hCMEC/D3 cells were incubated with MGO (0.25, 0.50, 0.75, 1.00 and 1.25 mmol/L) for 24 h. Cell viability was detected by CCK-8 assay. Cellular LDH and SOD activities were determined by commercially available kits. The change of mitochondrion membrane potential was assessed by JC-1 probe. MitoSOX probe was used to observe mitochondrial reactive oxygen species (mROS) release. Results Compared with control, cell viability of hCMEC/D3 treated with MGO decreased in a concentration-dependent manner (P＜0.01). Increased LDH activity and decreased SOD activity were observed with MGO exposure (P＜0.01). The decrease of mitochondrion membrane potential and the excessive increase of mROS were induced after MGO exposure for 12 h, which were detected by JC-1 or MitoSOX probe. Conclusions MGO reduces cell viability and mitochondria membrane potential in hCMEC/D3 cells with excessive mROS generation. [ABSTRACT FROM AUTHOR]

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Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

【目的】初步探讨在女性肿瘤患者生育力保存中，不同促排卵方案以及卵母细胞体外成熟技术的临床效果。【方法】分析中山大学附属第六医院生殖医学研究中心27例女性肿瘤患者冷冻卵子或胚胎的临床资料。【结果】纳入的女性肿瘤患者平均年龄为27.1岁，从就诊日开始算起，平均用6.8d获卵，促性腺激素平均总用量为910U。其中乳腺癌患者促排卵期间的最高雌激素水平约为360pg/mL。促排卵周期卵子成熟率约为82.6%，而紧急取卵后行卵母细胞体外成熟的成熟率为38.1%。【结论】年轻女性肿瘤患者的卵巢反应性普遍较好，不同获卵方案均能达到可观的效果，卵子及胚胎质量无明显下降；联合应用来曲唑可较好地控制患者促排卵期间体内的雌激素水平；紧急取卵后行卵母细胞体外成熟的成熟率较低。在临床应用上，我们应根据患者的原发肿瘤疾病特点、就诊时机个性化选择获卵方案。

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【目的】比较常规控制性卵巢刺激（COS）和微刺激方案在卵巢低反应（POR）患者行体外受精-胚胎 移植（IVF-ET）中的临床结局。【方法】前瞻入组行体外受精/卵胞浆内单精子注射（ICSI）治疗的卵巢低反应患者 随机分为两组，COS组选择促性腺激素释放激素激动剂（GnRH-a）修饰长方案，微刺激方案组选择来曲唑（LE）添 加小剂量促性腺激素（Gn）行卵巢刺激，比较两组患者促排效果及临床妊娠结局差异。【结果】COS组患者扳机日 子宫内膜厚度（mm）和扳机日血清雌二醇（E2）水平（pg/mL）显著高于微刺激组，分别为11.4±2.5vs.9.6±2.5、 1200±710vs.560±470，差异均有统计学意义（P＜0.05）；两组扳机日血清黄体生成素（LH）、孕激素（P）水平差 异无统计学意义（P＞0.05）；COS组患者获卵数（4.1±2.8vs.2.8±1.9）和可利用胚胎数（2.0±1.6vs.1.5±1.4）均 多于微刺激组，差异有统计学意义（P＜0.05）；两组的胚胎种植率，每移植周期、每取卵周期以及每启动周期的临 床妊娠率，流产率，活产率差异均无统计学意义（P＞0.05）。【结论】在POR患者促排治疗中，微刺激方案和COS 方案相比有相近的临床妊娠率。而微刺激方案可节约Gn用量、缩短促排卵时间。因此微刺激方案是POR患者 较理想的促排卵方案。

【目的】比较卵巢低反应患者进行卵巢轻微刺激和控制性卵巢刺激体外受精-胚胎移植（IVF-ET）周期中卵泡液内激素水平、细胞因子的差异及其与获卵数、胚胎数等的关系。【方法】本研究为观察性研究。招募符合博洛尼亚标准的卵巢低反应患者，随机分为实验组（组2）和对照组（组1）。实验组采用来曲唑及低剂量外源性促卵泡生成素（Gn）进行卵巢轻微刺激，对照组采用常规控制性卵巢刺激（黄体期GnRH激动剂修饰长方案）进行卵巢刺激。于取卵日收集成熟卵泡（>16 mm）的卵泡液，其中实验组共23例，对照组共28例，测量卵泡液中促卵泡生成素（FSH）、促黄体生成素（LH）、雌激素（E2）、孕激素（P）、睾酮（T）和抗苗勒管激素（AMH）水平，以及抑制素（inhibin）、生长分化因子9（GDF9）和骨形成蛋白家族（BMP）水平。统计分析卵泡液中各激素、因子水平与获卵数、可利用胚胎数及优质胚胎数的相关性。【结果】实验组和对照组患者基本情况各指标之间：年龄、不孕年限、基础FSH、和窦卵泡数（AFC）差异均无显著性意义（P>0.05）。与对照组相比，实验组Gn用量更少，但两组的获卵数，可利用胚胎数及优质胚胎数差异均无统计学意义（P>0.05）。与对照组相比，实验组卵泡液中LH水平、睾酮水平和inhibin B水平明显增高，而FSH水平、inhibin A水平、BMP8B和GDF9水平明显降低。其他几种激素水平，包括E2、P、AMH和BMP2、6、8B、15水平，两组间差异无显著性意义（P>0.05）。相关分析显示，卵泡液中各激素和细胞因子水平均与获卵数、可移植胚胎数及优质胚胎数无相关性。【结论】POR患者使用不同的轻微刺激和常规控制性卵巢刺激，卵泡微环境不同。但未发现这些变化与获卵数、可利用胚胎数、优质胚胎数存在相关性。

To comprehensively understand the effect of selenium(Se)supplementation on Codonopsis pilosula, effects of sodium selenite levels on Se accumulation, growth, physiology and quality were explored by using hydroponic experiments. The results were as follows:(1)Treatment with 0.2 mg·L-1 Se promoted leaf size, plant height and biomass of C. pilosula, while treatment with 10 mg·L-1 Se suppressed them.(2)Both increasing Se level and exposure time to C. pilosula seedlings could raise its Se contents in root and leaf, and Se was distributed in organs with an order of root>leaf>stem.(3)Treatment with 0.2 mg·L-1 Se increased photosynthetic pigment content and root activity, and reduced malondialdehyde, proline and hydrogen peroxide contents, while treatment with 10 mg·L-1 Se had opposite effects.(4)Treatment with 0.2 mg·L-1 Se had positive effects on accumulations of lobetyolin, polysaccharide, and soluble protein, while treatment with 10 mg·L-1 Se had negative effects on the accumulations of polysaccharide and soluble protein. In summary, sodium selenite has double effect on C. pilosula; application of appropriate Se is beneficial to its growth, plant physiology and quality, and 0.2 mg·L-1 Se level is the optimum. This study may improve us to understand the effect of selenite level on the biology effect of C. pilosula, which will be useful for the basic research and cultivation of Se-enriched C. pilosula. [ABSTRACT FROM AUTHOR]

The restoration and reconstruction of mangrove wetland ecosystem is one of the key research fields in ecological restoration in the coastal zone of South China. In order to reveal the physiological and ecological strategies to light conditions of mangrove species, the characteristics of leaf soluble protein contents and activities of antioxidant enzymes in seedlings of eight mangrove species(Sonneratia apetala, Kandelia obovata, Bruguiera gymnorhiza, Aegiceras corniculatum, Acanthus ilicifolius, Acrostichum aureum, Heritiera littoralis and Hibiscus tiliaceus)under different light intensity treatments(100%, 45%, 30%, and 10% of natural light intensity)were studied using shading control experiment. The results were as follows:(1)Low light intensities had little effect on the leaf soluble protein contents of Bruguiera gymnorhiza, Acanthus ilicifolius and Acrostichum aureum, whereas the other five species showed a decreasing trend of leaf soluble protein contents with the decline in light intensity.(2)The activities of superoxide dismutase(SOD)and ascorbate peroxidase(APX)in the leaves of Bruguiera gymnorhiza, Acanthus ilicifolius and Acrostichum aureum under 10% of natural light intensity treatment had no significant differences compared with the control, while the other five mangrove species showed a decreasing trend of all the five antioxidant enzyme activities. In conclusion, the results indicate that Bruguiera gymnorhiza, Acanthus ilicifolius and Acrostichum aureum are suitable to be planted under the forest with high canopy density, while Sonneratia apetala, Kandelia obovata, Aegiceras corniculatum, Heritiera littoralis, Hibiscus tiliaceus are suitable to be planted under the forest with lower canopy density or planted as middle and upper layer tree species in mangrove. The results of this study provide theoretical guidance for the optimal allocation of artificial mangrove communities. [ABSTRACT FROM AUTHOR]

【目的】探讨全囊胚培养是否能使高龄低储备不孕患者获益。【方法】回顾性分析2016年5月至2017年4月于 中山大学附属第六医院生殖医学研究中心就诊，采用IVF/ICSI助孕的高龄低储备不孕患者。根据第3天（D3）可移植胚胎的 处理方式分为全养囊胚组（A组）及不养囊胚组（B组），比较两组的累积生化妊娠率，累积临床妊娠率。【结果】一共纳入符 合条件的231名患者进行统计，A组130名，B组101名。两组患者的基本情况无差异。A组的累积生化妊娠率/临床妊娠率 高于B组，差异无统计学意义（P＞0.05）。剔除A组中因无囊胚形成而最终未行胚胎移植的患者后，A组的累积生化妊娠率/ 临床妊娠率显著优于B组（P＜0.05）。对患者基本情况与培养囊胚结局的多因素分析结果显示：D3可移植胚胎数少是培养 囊胚失败的危险因素（OR=0.277，95%CI为0.103 ~ 0.744，P＜0.05）。【结论】高龄低储备不孕患者行全囊胚培养不会对妊 娠结局造成不利影响。相反，只要培养成囊胚可供移植，囊胚培养组的妊娠结局优于不养囊胚组；D3可移植胚胎数量少是 培养囊胚失败的危险因素。在对患者进行充分地知情告知后，我们可酌情考虑对部分高龄低储备不孕患者行全囊胚培养。

【目的】比较卵裂期胚胎及囊胚移植后早期血清 β-人绒毛膜促性腺激素（β-hCG）对体外受精-胚胎移植 （IVF-ET）妊娠结局的预测作用。【方法】回顾性分析自2010年6月至2015年5月共2 421个在本中心行IVF-ET后临床确认 宫内单胎妊娠的患者周期的数据。比较分析卵裂期胚胎移植后14 d的血清β-hCG值及囊胚移植后12 d的血清β-hCG值与妊 娠结局的关系。【结果】对于临床确认宫内妊娠的患者，囊胚移植组的早期β-hCG水平高于卵裂期胚胎移植组（687 U/L vs 503 U/L）。根据妊娠结局分组后，这种差异同样存在于自然流产、继续妊娠（OP）及活产（LB）的患者中。根据新鲜或冷冻移植 分组后，这种差异仅在冷冻移植组中有统计学意义。对于冷冻卵裂期胚胎移植的患者，以β-hCG>475 U/L作为活产的预测值 （灵敏度79.0%，特异度61.3%）。对于冷冻囊胚移植的患者，以β-hCG>575 U/L作为活产的预测值（灵敏度74.9%，特异度 59.2%）。【结论】冷冻移植周期中，囊胚移植的早期血清β-hCG值高于卵裂期胚胎。移植胚胎时期不同，应用早期血清β- hCG值预测妊娠结局的预测值也不同。囊胚或卵裂期胚胎移植后的早期血清β-hCG值均能有效预测活产结局。

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and purpose: Anti-programmed death-1 (anti-PD-1) adjuvant therapy and targeted therapy have resulted in longer recurrence-free survival (RFS) for malignant melanoma patients in clinical trials. However, the efficacy of adjuvant anti-PD-1 therapy in Chinese melanoma patients has not been previously reported. The purpose of this study was to retrospectively analyze the RFS in Chinese resected stage III malignant melanoma patients treated with adjuvant anti-PD-1 therapy and to preliminarily compare it with BRAFV600 inhibitor vemurafenib. Methods: This study retrospectively collected the information of 120 patients with resected stage Ⅲ malignant melanoma from three major cancer centers in China from August 30, 2018 to August 30, 2020. These patients received adjuvant pembrolizumab/toripalimab or vemurafenib. RFS rates were assessed by Kaplan-Meier curves and log-rank tests were used to examined differences. Results: Among the 90 patients with stage III malignant melanoma receiving adjuvant anti-PD-1 therapy, the median-RFS (mRFS) was 16 months (95% CI: 14-18 months); the 12-month RFS rate was 69.5% (95% CI: 64.6%-74.4%) and the 24-month RFS rate was 45.8% (95% CI: 40.5%-51.1%). The mRFS for 30 patients who received vemurafenib was 18 months (95% CI: 10-21 months), the 12-month RFS rate was 62.8% (95% CI: 54.0%-71.6%), and the 24-month RFS rate was 32.9% (95% CI: 27.1%-44.7%). In the stratified analysis, firstly, there was no difference in RFS between anti-PD-1 therapy group and vemurafenib group. Secondly, the BRAFV600E mutation status may did not affect the RFS of anti-PD-1 therapy. In addition, in this study, for the patients with BRAFV600E mutation, the RFS showed no difference between these patients received anti-PD-1 therapy or vemurafenib. Finally, although the RFS was better in patients with cutaneous melanoma than in patients with acral and worst in patients of unknown origin, the data for adjuvant therapy in China were still poor. Conclusion: These are the real-world data from adjuvant anti-PD-1 therapy in patients with resected stage III cutaneous and acral melanoma patients in China. In our study, adjuvant anti-PD-1 therapy is indistinguishable from vemurafenib indicates more combination therapies are needed to improve outcome in China. [ABSTRACT FROM AUTHOR]

Copyright of Guihaia is the property of Guihaia Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Oncology is the property of Editorial Board of China Oncology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective* To compare the ability of VDW Reciproc Blue (Blue), FKG XP-endo shaper (XP) and M3-L platinum (M3) instruments to maintain the original curvature of root canal (i. e. central positioning ability) in preparing curved root canals. Methods • Thirty resin-simulated curved single root canals were randomly divided into three groups. Root canal preparation was performed with a Blue file, an XP file or an M3 file randomly. Red or blue-black ink was injected into the root canal before and after preparation and photographs were taken under the stomatology surgical microscope. The images before and after preparation were overlapped. The apex of the prepared root was set as a circle center and the radius started at 1 mm. A concentric circle was made every 1 mm increased and sequentially incremented to 10 mm so that it intersected the image to form 10 measurement sites, and then the removal of ten measurement sites on the inside and outside of the root canal was recorded for statistical analysis. After the root canal was prepared the file was observed for tensile deformation under the stomatology surgical microscope. Results • There was significant difference in the absolute value of the difference between the internal and external removal of root canal between the M3 group and the Blue group, as well as the M3 group and the XP group (P=0.003 1, P=0.002 0); but there was no significant difference between the Blue group and the XP group (P=0.350). The file body of XP group was observed to have de-helix deformation under the stomatology surgical microscope, which did not return to its original shape when placed in hot water, and no deformation was observed in the file body of M3 group and Blue group. Conclusion • The three kinds of single-file nickel-titanium instruments have good formation ability when preparing the curved root canals. But XP file and Blue file can maintain the original curvature of root canals better than M3 file. XP files are prone to deformation when preparing resin root canal, therefore the use of XP should be appropriately reduced clinically. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Trastuzumab deruxtecan (DS-8201a) is a novel antibody-drug conjugate (ADC) of human epidermal growth factor receptor 2 (HER2) targeted antibody and DNA topoisomerase Ⅰ inhibitor (deruxtecan, DXd). DS-8201a has the characteristics of loading new cytotoxic drugs, high proportion of drug antibodies and high cell membrane permeability. Compared to traditional anti-HER2 drugs only aimed at patients with overexpression of HER2, DS-8201a can also play a role in tumors with high and low expressions of HER2. So far, phase Ⅰ to Ⅲ clinical trials have been carried out in a variety of solid tumors, such as breast cancer, gastric cancer, colorectal cancer and non-small cell lung cancer. Studies have shown results, including indications, toxicity and safety, determination of effective dose, comparison with existing first-line and posterior-line standard chemotherapy regimens, and efficacy comparison between monotherapy and combination therapy. It may provide a new therapeutic method for clinical treatment of tumors with overexpression or low expression of HER2, and pulmonary symptoms should be monitored during use. In this review, the drug structure characteristics, related clinical research progress and prospect of DS-8201a were summarized. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Mine Automation is the property of Industry & Mine Automation Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The dynamic study of community structure in karst area is a key problem to be solved in ecological reconstruction and rocky desertification control. Based on the monitoring data of six permanent monitoring sample plots in Puding County of Central Guizhou Province in 2013, 2015 and 2019, the dynamic characteristics of important value, species fluctuation structure, species diversity, diameter class structure and vertical structure of karst secondary forest in seven years were analyzed. The results were as follows:(1)The dominant degree and regeneration rate of Kalopanax septemlobus and Celtis sinensis increased, while the important values of Zanthoxylum armatum, Campylotropis macrocarpa and Pyracantha fortuneana decreased, and the mortality rate was higher.(2)There was no significant differences in species diversity indexes between different years. Species richness and Margalef richness index increased first and then decreased. Shannon-Wiener diversity index was basically stable, and uniformity index decreased first and then increased, the differences were significant between 2013 and 2019.(3)The distribution of diameter class and tree height showed “inverted J” and “left partial normal” distribution, and there was no significant differences in different years. The number of individuals of large diameter class(DBH≥10 cm)increased, but the number of tall trees(H≥9 m)decreased. In the shrub layer, the number of individuals of Pyracantha fortuneana, Campylotropis macrocarpa and Rhamnus rosthornii at 0≤H<3 m and 0≤DBH<2.5 cm, decreased, while the number of individual tree species such as Kalopanax septemlobus and Celtis sinensis increased. The natural succession process of karst secondary forest is slow and complex, and the hierarchical structure is not obvious. The community is in the middle and early stage of succession, and the community regeneration is good, which will further develop in the direction of arbor dominance [ABSTRACT FROM AUTHOR]