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To explore the correlation between the indexes of echocardiography and fetal chromosomal abnormalities. A total of 980 high-risk pregnant women, who received prenatal echocardiography in Northwest Women and Children's Hospital from January 2017 to January 2020, were chosen as research subjects, and their echocardiography and chromosomal karyotype detection were carried out, and the specific situation of chromosomal karyotype abnormality was recorded to screen out chromosomal karyotype abnormality Maternal (80 cases) as study group, another 900 cases of normal maternal chromosome as control group. The maternal echocardiography indicators left ventricular Tei index, right ventricular Tei index and neck translucent layer thickness (NT) value differences were compared between the two groups. The correlation of the above echocardiographic indicators were explored by Spearman correlation analysis, and a graph of the diagnostic value of echocardiographic indicators for fetal chromosomal abnormalities was finally drawn. (1) The Tei index of left ventricle, Tei index of right ventricle and NT value of the study group were significantly higher than those of the control group, and the difference between the two groups was statistically significant (P<0.05). (2) Correlation analysis showed that NT value was positively correlated with Tei value of left ventricle and TEI value of right ventricle (r=0.8927). (3) ROC curve showed that the AUC of TEI value in left ventricle, TEI value in right ventricle and NT value in the diagnosis of fetal chromosomal abnormalities were 0.9889, 0.7574 and 0.7959 respectively (P<0.05). There is a significant correlation between echocardiographic indexes and fetal chromosomal abnormalities. Echocardiography can be considered as a screening method for fetal chromosomal abnormalities in the clinical application. [ABSTRACT FROM AUTHOR]

To explore the diagnostic value of echocardiography combined with electrocardiogram in the second trimester of pregnancy. The clinical related indicators of 80 foeti, who were diagnosed as heart malformation after birth and autopsy in the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from January 2019 to January 2021, were retrospectively analysed. The echocardiography and fetal ECG examination results of 80 foeti were analysed, and the value of echocardiography combined with ECG in the diagnosis of fetal heart malformation in the second trimester of pregnancy was analysed. In the 80 feti, there were 56 cases of ECG abnormalities of varying degrees, including 3 cases of premature fetal heart beats, 12 cases of increased FQRS amplitude, 15 cases of ST segment changes, 3 cases of FQRS time limit widening, 4 cases of fetal heartbeat, 4 cases of fetal heartbeat 3 cases of fetal bradycardia, and 16 cases of fetal tachycardia. In the 80 feti, through autopsy and post-natal follow-up, there were 4 cases of left heart dysplasia syndrome (HLHS), 6 cases of single atrium, 8 cases of complete endocardial cushion defect (ECD), and 14 cases of tetralogy of Fallot (TOF), 17 cases of the diameter of the foramen ovale being greater than 6 mm, and 31 cases of ventricular septal defect (VSD). There was no significant difference compared with the diagnosis result of echocardiography(P>0.05). There were 7 cases of missed diagnosis in echocardiography. There was no significant difference between combined diagnosis and echocardiography and electrocardiogram in the diagnosis of left heart dysplasia syndrome, single ventricle, and total endocardial cushion defect in feti (P>0.05). For tetralogy of Fallot, greater than 6 mm of diameter of foramen ovale, ventricular septal defect, and cardiac malformation, the combined diagnosis is superior to the single diagnosis of echocardiography and electrocardiography (P<0.05). Through the comparison of the detection value of different examinations, it was found that the accuracy, sensitivity, specificity, positive predictive value and negative predictive value of echocardiography combined with ECG were significantly higher than that of echocardiography and ECG alone. Echocardiography and electrocardiography are of great value in the diagnosis of fetal heart malformations in the second trimester of pregnancy. For cardiac malformation fetus in the second trimester of pregnancy, ECG examination shows abnormal phenomenon, but can not be diagnosed as cardiac malformation, still needs further to use echocardiography to diagnose whether or not there is fetal cardiac malformation in the second trimester of pregnancy. [ABSTRACT FROM AUTHOR]