1. [L-carnitine-astaxanthin compound nutrients for the treatment of idiopathic oligospermia and asthenozoospermia: A multicenter clinical observation].
- Author
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Li H, Deng H, Liu H, Zhong A, Weng ZW, Huang CP, Luo QX, Zhao SC, Zhu YT, DU P, Mo XD, Luo DS, Xie SS, Xie Q, and Zhang XZ
- Subjects
- Carnitine therapeutic use, Humans, Male, Nutrients, Semen Analysis, Xanthophylls, Asthenozoospermia drug therapy, Oligospermia drug therapy
- Abstract
Objective: To investigate the clinical effects of the L-carnitine-astaxanthin compound nutrients Menglankang (MLK) on idiopathic oligospermia (OS) and asthenospermia (AS)., Methods: This study included 73 cases of OS and 220 cases of AS treated with MLK once a bag, bid, for 3 successive months. Before and at 1, 2 and 3 months after treatment, we obtained and analyzed the semen parameters and sperm DNA fragmentation index (DFI) of the patients., Results: Compared with the baseline, the OS patients showed remarkable increases after 1 and 2 months of treatment in the semen volume ([3.07 ± 1.47] vs [3.26 ± 1.26] and [3.30 ± 1.28] ml), sperm concentration ([10.96 ± 6.09] vs [16.74 ± 11.15] and [17.56 ± 9.92] ×10⁶/ml, P < 0.05), total sperm count ([29.78 ± 17.48] vs [52.98 ± 32.07] and [57.67 ± 36.98] ×106, P < 0.05) and the percentages of progressively motile sperm (PMS) ([39.8 ± 11.66]% vs [45.3 ± 14.03]% and [46.42 ± 10.69]%, P < 0.05) and morphologically normal sperm (MNS) ([1.71 ± 1.07]% vs [1.79 ± 0.91]% and [1.84 ± 0.96]%), and so did the AS patients in PMS ([19.23 ± 8.32]% vs [25.46 ± 13.86]% and [27.33 ± 12.88]%, P < 0.05). After 3 months of medication, the OS patients exhibited even more significant increases in the semen volume ([3.63 ± 1.39] ml) (P < 0.05), sperm concentration ([20.56 ± 14.7] ×10⁶/ml) (P < 0.05), total sperm count ([66.35 ± 55.91] ×106) (P < 0.05), PMS ([49.24 ± 13.45]%) (P < 0.05) and MNS ([2.59 ± 0.93]%) (P < 0.05), and so did the AS patients in the semen volume ([3.27 ± 1.42] vs [3.85 ± 1.59] ml, P < 0.05), PMS ([29.11 ± 13.58]%) (P < 0.05) and NMS ([2.01 ± 1.14]% vs [2.57 ± 1.15]%, P < 0.05). In comparison with the baseline, the sperm DFI was not significantly improved at 1 month after treatment, but remarkably decreased at 2 and 3 months in the OS patients ([25.87 ± 13.76]% vs [18.66 ± 10.83]% and [16.48 ± 11.46]%, P < 0.05) and the AS patients as well ([26.40 ± 12.28]% vs [19.35 ± 11.54]% and [15.32 ± 10.89]%, P < 0.05)., Conclusions: The L-carnitine-astaxanthin compound nutrients Menglankang can significantly improve the semen quality of the patients with idiopathic oligospermia or asthenospermia.
- Published
- 2021