1. Concentration of Non-Steroidal Anti-Inflammatory Drugs in the Pelvic Floor Muscles: An Experimental Comparative Rat Model
- Author
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Mei Fung Lin, Chi Hsin Chiang, Chin Jung Wang, Eileen Changchien, and Hung Yen Chin
- Subjects
Naproxen ,Diclofenac ,Nabumetone ,Thiazines ,Piroxicam ,Meloxicam ,Pelvic Pain ,Pelvic Floor Muscle ,medicine ,otorhinolaryngologic diseases ,Potency ,Animals ,Rats, Wistar ,non-steroid anti-inflammation drugs ,Pelvic floor ,business.industry ,Pelvic pain ,Muscles ,Anti-Inflammatory Agents, Non-Steroidal ,Chronic pain ,Obstetrics & Gynecology ,General Medicine ,Pelvic Floor ,medicine.disease ,myofacial pain syndrome ,Butanones ,Rats ,body regions ,Thiazoles ,medicine.anatomical_structure ,Anesthesia ,Original Article ,Female ,medicine.symptom ,Chronic Pain ,business ,pelvic floor muscle ,medicine.drug ,Chronic pelvic pain - Abstract
Purpose The aim of this study is to explore non-steroid anti-inflammation drugs (NSAIDs) potency for pelvic floor muscle pain by measuring local concentration in a rat model. Materials and Methods We used nine NSAIDs, including nabumetone, naproxen, ibuprofen, meloxicam, piroxicam, diclofenac potassium, etodolac, indomethacin, and sulindac, and 9 groups of female Wister rats. Each group of rats was fed with one kind of NSAID (2 mg/mL) for three consecutive days. Thereafter, one mL of blood and one gram of pelvic floor muscle were taken to measure drug pharmacokinetics, including partition coefficient, lipophilicity, elimination of half-life (T1/2) and muscle/plasma converting ratio (Css, muscle/Css, plasma). Results Diclofenac potassium had the lowest T1/2 and the highest mean Css, muscle/Css, plasma (1.9 hours and 0.85±0.53, respectively). The mean Css, muscle/Css, plasma of sulindac, naproxen and ibuprofen were lower than other experimental NSAIDs. Conclusion Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle.
- Published
- 2014