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Concentration of Non-Steroidal Anti-Inflammatory Drugs in the Pelvic Floor Muscles: An Experimental Comparative Rat Model.

Concentration of Non-Steroidal Anti-Inflammatory Drugs in the Pelvic Floor Muscles: An Experimental Comparative Rat Model.

Authors :
Hung-Yen Chin
Eileen Changchien
Mei-Fung Lin
Chi-Hsin Chiang
Chin-Jung Wang
Source :
Yonsei Medical Journal; Jul2014, Vol. 55 Issue 4, p1095-1100, 6p
Publication Year :
2014

Abstract

Purpose: The aim of this study is to explore non-steroid anti-inflammation drugs (NS AIDs) potency for pelvic floor muscle pain by measuring local concentration in a rat model. Materials and Methods: We used nine NSAIDs, including nabume-tone, naproxen, ibuprofen, meloxicam, piroxicam, diclofenac potassium, etodolac, indomethacin, and sulindac, and 9 groups of female Wister rats. Each group of rats was fed with one kind of NSAID (2 mg/mL) for three consecutive days. Thereafter, one mL of blood and one gram of pelvic floor muscle were taken to measure drug pharmacokinetics, including partition coefficient, lipophilicity, elimination of half-life (T<subscript>1/2</subscript>) and muscle/plasma converting ratio (C<subscript>ss,muscle</subscript>/C<subscript>ss,plasma</subscript>). Results: Diclofenac potassium had the lowest T<subscript>1/2</subscript> and the highest mean C<subscript>ss,muscle</subscript>/C<subscript>ss,plasma</subscript> (1.9 hours and 0.85±0.53, respectively). The mean C<subscript>ss, muscle</subscript>/C<subscript>ss, plasma</subscript> of sulindac, naproxen and ibuprofen were lower than other experimental NSAIDs. Conclusion: Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
05135796
Volume :
55
Issue :
4
Database :
Supplemental Index
Journal :
Yonsei Medical Journal
Publication Type :
Academic Journal
Accession number :
96804687
Full Text :
https://doi.org/10.3349/ymj.2014.55.4.1095