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A patent has been issued for a system designed to improve tissue handling and in-line analysis during biopsies, particularly for breast cancer screening. The system aims to streamline the process of obtaining and analyzing tissue samples, reducing the need for repeat biopsies and human intervention. Developed by Hologic Inc., the system includes a specimen holder and an analysis unit to enhance the efficiency and accuracy of tissue analysis. The invention addresses the challenges associated with tissue manipulation and imaging in biopsy procedures, ultimately benefiting patients and healthcare providers in the field of oncology and women's health. [Extracted from the article]

A patent has been issued for a needle breast biopsy system and method of use by Hologic Inc. The invention aims to improve breast biopsy procedures by providing a stereotactic needle biopsy assembly that allows for motorized guidance of the biopsy device to a target location during a biopsy for excising tissue. This system is designed to be integrated into various x-ray imaging platforms, including tomosynthesis systems, to enhance patient coverage and reduce exposure to radiation. The patent details the technical specifications and features of the lateral biopsy unit and needle breast biopsy system. [Extracted from the article]

A patent has been issued for an X-ray system developed by inventors from The Nottingham Trent University in the United Kingdom. The system aims to improve the accuracy of diagnostics for diseases like cancer by probing biological samples using X-ray radiation. The patent describes a sample inspection system that includes an X-ray emitter, collimator, and energy-resolving detector to detect diffracted or scattered radiation from the sample. This technology could potentially enhance non-invasive biopsy procedures and reduce the need for costly and stressful traditional biopsies. [Extracted from the article]

A recent study conducted by the Broad Institute of Harvard & MIT focused on metastatic breast cancer biopsies, utilizing a multi-modal approach to map cellular and spatial expression across diverse clinicopathological features. The research combined single-cell RNA sequencing with spatial profiling techniques to identify patient-specific gene expression programs and spatial phenotypes correlated with microenvironmental features. The study concluded that these methods provide valuable insights into the molecular characteristics of breast cancer metastases. [Extracted from the article]

A recent study conducted in Evanston, Illinois, focused on the time intervals between breast cancer screening and treatment at accredited breast centers in the United States. The study found that the time from biopsy to first treatment was longer than expected compared to the time from screening to diagnosis. Variability in time intervals across different centers was noted, with some facing more challenges in meeting timely quality measures. The research suggests further investigation into whether these differences impact patient outcomes. [Extracted from the article]

A study conducted by Mahidol University in Bangkok, Thailand, examined the impact of the time between breast cancer diagnosis and surgery on axillary nodal metastasis in early breast cancer patients. The research found that delays in surgery were associated with more advanced nodal staging, particularly in T1 tumors. The study emphasized the importance of timely intervention in early breast cancer cases to prevent disease progression. For more information, readers can refer to the article "Post-biopsy to Surgery Interval Tends to Increase Axillary Nodal Metastasis, Especially in Early Breast Cancer Patients" published in the Siriraj Medical Journal. [Extracted from the article]

Researchers at Medical University - Pleven in Bulgaria conducted a nationwide analysis of breast cancer guidelines adherence in the country from January 2019 to August 2023. The study found that while core-needle biopsy rates for breast cancer diagnosis were lower than desired, there were unacceptably high rates of frozen section use for intraoperative diagnosis. Additionally, rates of sentinel lymph node biopsy were unreasonably low, indicating room for improvement in diagnostic and treatment practices for breast cancer in Bulgaria. The research was published in Clinical Surgical Oncology and was supported by the European Regional Development Fund. [Extracted from the article]

Researchers from the University of Paris Saclay have conducted a study on the immediate diagnosis of breast carcinoma using ex vivo fluorescence confocal microscopy (FCM) on core needle biopsies. The study found that FCM showed promise in providing an immediate diagnosis of breast carcinoma in a one-stop clinic setting while preserving tissue specimens for final histology. The research involved 50 women with breast masses, and FCM identified malignancy cases with high accuracy, demonstrating potential as a new histological method in breast cancer diagnostics. The study was conducted at Gustave Roussy's one-stop breast clinic in Villejuif, France, and the findings were published in the journal Life. [Extracted from the article]

A recent study from Saint Petersburg State University explores modern endoscopic techniques for sentinel lymph node biopsy and axillary lymph node dissection in breast cancer surgery. The research highlights the benefits of these techniques, such as more accurate diagnosis and reduced patient risks, compared to conventional open techniques. The study also discusses the impact of endoscopic axillary lymph node dissection on patient prognosis and quality of life. For more information, the full article is available for free online. [Extracted from the article]

A study conducted at Command Hospital in West Bengal, India, evaluated the feasibility of using four-node axillary sampling (FNAS) as an alternative to sentinel lymph node biopsy (SLNB) in managing node-negative breast cancer patients. The research found that while SLNB is a useful method for axillary staging in node-negative patients, FNAS showed high false-negative rates and limited diagnostic value. Further research, including larger studies and randomized controlled trials, is needed to determine the efficacy and potential role of FNAS in managing node-negative breast cancer in low-resource settings. [Extracted from the article]

A recent study conducted by researchers at Universitas Sumatera Utara in Indonesia focused on the use of immunohistochemistry (IHC) alone versus IHC combined with Hematoxylin and Eosin (H&E) staining in sentinel lymph node biopsy for breast cancer patients who underwent neoadjuvant chemotherapy. The study, which included a meta-analysis of 16 studies involving 1,456 patients, found that the combination of IHC with H&E offered comparable accuracy for axillary staging in clinically node-negative breast cancer patients post-chemotherapy. The research concluded that there was no significant difference in the false-negative rate between the two staining methods. [Extracted from the article]

Researchers at Tampere University conducted a study using micro-computed tomography to evaluate eosin-stained axillary lymph node biopsies of female breast cancer patients. The study aimed to improve error detection, enhance histopathological accuracy, and measure metastatic lesions in a three-dimensional format. The research showed potential for improved tumor deposit estimates compared to standard 2D histology, but further validation studies are needed. For more information, readers can access the full article in Scientific Reports. [Extracted from the article]

A recent study conducted by the Institute for Biomedical Engineering in Toronto, Canada, focused on profiling breast tumor heterogeneity and identifying breast cancer subtypes through tumor-associated immune cell signatures and Immuno Nano Sensors. The research highlighted the complexity of breast cancer and the importance of detecting intratumor heterogeneity for effective treatment decisions. By utilizing immune cells and machine-learning approaches, the study successfully distinguished cancer from healthy samples, identified primary versus metastatic tumors, and determined estrogen receptor/progesterone receptor status at the single-cell level. The findings suggest that immune cell-based metabolic profiling could offer a comprehensive assessment of breast tumor heterogeneity, potentially leading to minimally invasive liquid biopsy approaches for breast cancer diagnosis and management. [Extracted from the article]

A patent application titled "Biopsy Positioner for Mammography Imaging System" was published online by inventors from France. The application focuses on improving mammography imaging procedures, particularly for breast cancer screening and diagnosis. The invention aims to enhance the effectiveness of spectral mammography by providing a system that allows for better positioning and guidance of biopsy devices during imaging procedures. The patent application details the design and functionality of the proposed biopsy positioner for mammography systems. [Extracted from the article]

A recent study conducted at the University of Copenhagen explored the use of deep learning to predict future breast cancer risk in healthy female donors based on senescence markers in mammary tissue. The study analyzed over 4,000 female donors and found significant associations between senescence prediction scores in adipose tissue and the development of breast cancer. Combining multiple models improved the prediction of future breast cancer risk compared to current clinical benchmarks, suggesting a potential role for deep learning models in cancer risk assessment and screening protocols. The study was funded by Novocure Limited, Danish Cancer Society, and the National Institutes of Health (NIH) in the USA. [Extracted from the article]

A recent study conducted by researchers at Inner Mongolia Medical University focused on the prevalence of high risk for breast cancer among women aged 35 to 64 in the agricultural and herding areas of Hinggan League, Inner Mongolia Autonomous Region. The study found that 26.76% of the participants were classified as being at high risk for breast cancer, with factors such as age, ethnicity, education level, menopausal status, family history of breast cancer, and previous breast examinations influencing the risk. The research provides valuable insights for local breast cancer prevention and control efforts in the region. [Extracted from the article]

A recent study conducted by researchers from the National Cancer Institute in Aviano, Italy, explores the potential of liquid biopsies in the management of triple-negative breast cancer (TNBC). The study highlights the limitations of current biomarkers and suggests that liquid biopsies, such as circulating tumor cell characterization and circulating tumor DNA, could be valuable tools for determining treatment efficacy, detecting early relapse, and monitoring clonal evolution during treatment. The researchers believe that these biomarkers may play a crucial role in identifying early disease relapse, therapeutic targets, and disease clonality in TNBC patients. The study was supported by the Ministry of Health in Italy. [Extracted from the article]

This article discusses a clinical trial, NCT06610539, that aims to gather evidence on the frequency of skin discoloration and the detection rate of Sentinel Lymph Nodes in breast cancer patients undergoing lumpectomy. The trial will also evaluate the impact of skin discoloration on patients using patient-reported outcome measures. The study will assess various outcome measures, including the frequency and duration of skin discoloration, changes in patient-reported quality of life, and rates of device-related adverse events. The trial is open to the US population and is expected to be completed by June 2028. The study aims to provide evidence on the frequency of skin discoloration and the detection rate of Sentinel Lymph Nodes in patients who have received 1ml Magtrace for Sentinel Lymph Node Biopsy. The study also evaluates the impact of skin discoloration on patients using patient-reported outcome measures. The study will assess the non-inferiority of Sentinel Lymph Node detection rate with Magtrace compared to the American Society of Breast Surgeons performance standards. Participants will undergo lymph node mapping with Magtrace and Sentinel Lymph Node Biopsy, and the presence of Magtrace-related discoloration will be assessed. The study is not yet recruiting and is open to all genders aged 18 and above. [Extracted from the article]

A study conducted at Mashhad University of Medical Sciences in Iran explored the use of highly specific ultrasound criteria as an alternative to sentinel lymph node biopsy (SLNB) in breast cancer patients with axillary lymph node metastasis. SLNB is an expensive procedure that is not readily available to all patients and carries the risk of producing false negative results. The study identified specific ultrasound parameters, such as tumor size, cortical thickness of the axillary lymph node, short axis diameter of the node, and count of lymph nodes with a cortical thickness of >= 3 mm, that can diagnose lymph node metastasis with a high degree of certainty. The research concluded that a difference of >= 4.5 mm in cortical thickness between the suspected lymph node and the contralateral lymph node, as well as a cortical thickness of >= 6 mm, are ultrasound findings that can detect lymph node involvement with a specificity ranging from 95% to 100%. [Extracted from the article]

A researcher from the University of Baghdad has published findings on the use of sentinel lymph node biopsy (SLNB) in breast cancer patients. SLNB is a less invasive alternative to axillary lymph node dissection (ALND) for staging breast cancer, and it has been found to significantly reduce rates of lymphedema and arm morbidity. Patients treated with SLNB also reported better quality of life scores in emotional functioning, pain management, and physical mobility compared to those treated with ALND. These findings support the integration of SLNB into routine surgical management for eligible breast cancer patients. [Extracted from the article]

A recent study conducted in China examined the safety of omitting sentinel lymph node biopsy (SLNB) in patients with early-stage breast cancer who have clinically negative axillary lymph nodes. SLNB is a standard procedure for these patients, but it often results in postoperative complications. The study aims to determine if omitting SLNB is a safe alternative. The trial is a prospective, single-arm, non-inferiority, phase II study involving female breast cancer patients with a tumor of 3 cm in diameter. The primary endpoint is 3-year invasive disease-free survival, and secondary endpoints include the incidence of lymphedema and locoregional recurrence. The trial is expected to conclude in 2027. [Extracted from the article]

A case report from University Hospital discusses a rare presentation of lobular cancer in a 77-year-old female patient. The patient initially presented with significant weight loss and underwent various examinations, including colonoscopy and gastroscopy. Biopsies confirmed metastatic lobular carcinoma of the breast, and further examination revealed a large mass in the upper outer quadrant of the breast with palpable enlarged nodes. The research emphasizes the importance of a high index of suspicion for gastrointestinal metastatic disease from primary breast cancer, as the endoscopic findings can be non-specific. [Extracted from the article]

A recent study conducted by researchers at Sun Yat-Sen University Cancer Center explored the use of conventional ultrasonography (US) combined with quantitative shear wave elastography (SWE) in evaluating and identifying target axillary lymph nodes (TALN) for fine needle aspiration biopsy (FNAB) in patients with early breast cancer. The study found that the combined method of US and SWE had superior sensitivity compared to either method alone in diagnosing axillary lymph nodes (ALNs). The researchers concluded that the combined method may be a promising tool for preoperative diagnosis of ALNs in early breast cancer and could potentially impact the selection of axillary surgical stage. [Extracted from the article]

A recent study conducted by researchers at the University of Northern Colorado explores the expression and function of the high-affinity IgE receptor, FceRI, in breast cancer cells. The study found that breast cancer cells intrinsically expressed FceRI, which was unexpected. However, the functional analysis showed that IgE-mediated antigen stimulation did not elicit the same response in breast cancer cells as it did in mast cells. The researchers concluded that there is a significant difference between breast cancer models and human primary tumors, which should be considered when developing FceRI-relevant therapeutics. [Extracted from the article]

A recent study conducted at Minia University examined two methods commonly used for intraoperative examination of sentinel lymph nodes (SLNs) biopsy in breast cancer patients: imprint cytology (IC) and frozen section (FS). The study found that IC was comparable to FS in terms of accuracy, with IC being a simple, fast, easily performed, and inexpensive method for intraoperative SLN diagnosis. The sensitivity and specificity of IC were 60% and 97.4%, respectively, while FS had a sensitivity and specificity of 90% and 97.4%. Overall accuracy was 93.1% for IC and 96.6% for FS. This research provides valuable insights into the evaluation of SLN biopsy in breast cancer patients. [Extracted from the article]

A recent pilot study conducted at the Hospital of the University of Pennsylvania explored the feasibility and accuracy of ultrasound-guided core needle biopsy (US-CBN) for nipple lesions. The study found that US-CBN can be performed by a breast radiologist to diagnose suspicious nipple abnormalities seen on breast imaging, avoiding the need for surgery and preserving nipple integrity. Out of the nine patients who underwent US-CBN, two were diagnosed with malignancy. The study highlights the potential of US-CBN as a non-invasive alternative for diagnosing nipple abnormalities. [Extracted from the article]

A study conducted at Cambridge University Hospitals NHS Foundation Trust in the United Kingdom has reported a case of incidental breast cancer diagnosis during a lymphoscintigraphy procedure for cutaneous melanoma. The study involved a 51-year-old woman with a melanoma on her arm, who was found to have a micrometastasis of breast tissue in the sentinel lymph node. The patient was subsequently treated for stage III breast cancer. The research highlights the importance of recognizing the overlapping lymphatic distribution of sentinel lymph nodes, which can drain multiple organs. [Extracted from the article]

A clinical trial, NCT06509555, has been launched to explore the use of serum TK1 as a tumor marker to predict pathological remission of breast cancer with neoadjuvant chemotherapy. The trial aims to compare the levels and changes of sTK1 among different outcome groups in breast cancers with different molecular types. Female patients diagnosed with breast cancer and receiving neoadjuvant chemotherapy will be selected as study subjects, and their data will be collected for statistical analysis to determine the factors influencing pathological complete response (pCR) after neoadjuvant therapy. The trial is currently recruiting participants in China. [Extracted from the article]

A new report from the University of Missouri presents fresh data on breast cancer screening. The research focuses on the identification of microcalcifications in mammograms, which can indicate breast pathology. The study found that a 6-level approach to cutting biopsy specimens appears to be optimal for detecting microcalcifications. This finding may have implications for other types of specimens where a strong suspicion exists for a pathological lesion. The full article can be accessed for free online. [Extracted from the article]

A study conducted by researchers at the University of California Irvine examined the correlation between allostatic load (AL) and false-positive image-guided breast biopsies. AL refers to the accumulation of physiological dysregulation caused by repeated activation of the stress response over a lifetime. The study found that increased AL, a biological marker of stress, was associated with high-risk pathology among patients with false-positive breast biopsy results. The research was supported by the University of California Irvine Department of Radiology and has been peer-reviewed. [Extracted from the article]

A patent has been issued for a system and method for navigating x-ray guided breast biopsy. The patent, assigned to Hologic Inc., describes a method that targets and presents breast lesions reliably and accurately. The method involves generating a synthesized mammogram from 2D and/or 3D images of the breast, highlighting the lesion or feature of interest in the synthesized mammogram, and providing a user interface with a biopsy window to indicate correct targeting. The method also includes using a contrast agent and dual energy imaging to target and biopsy the lesion or feature of interest. The patent provides detailed descriptions of the method and its various embodiments. [Extracted from the article]

A recent report from researchers at Shandong University in China discusses the limitations of current breast cancer detection methods and highlights the potential of Surface-Enhanced Raman Spectroscopy (SERS) in liquid biopsy for breast cancer screening. SERS is a promising approach due to its high sensitivity, minimal sample requirements, and ability to detect various biomarkers. The review provides valuable insights into the application of SERS technology for early breast cancer diagnosis. This information may be useful for individuals conducting research on breast cancer screening and diagnostics. [Extracted from the article]

A recent study conducted by researchers at the Polytechnic University of Valencia in Spain has proposed the use of new biomarkers obtained from MCR-ALS as an alternative to curve-based pseudo-biomarkers and pharmacokinetics models for the detection and characterization of breast cancer. The researchers used PLS-DA with double cross-validation and variable selection to create a discrimination and prediction model between healthy tissue and cancer, achieving excellent average results for performance indexes. The study concluded that this approach could provide a unique probabilistic map called a "virtual biopsy" that helps specialists identify and characterize breast tumors using an easy-to-interpret biomarker map. This research has been peer-reviewed and published in Chemometrics and Intelligent Laboratory Systems. [Extracted from the article]

A patent application has been submitted for a breast biopsy immobilization device for magnetic resonance imaging (MRI). The device aims to optimize the compression and immobilization of the breast during setup before a breast MRI biopsy. It consists of a breast support with a flat plate and a compression device that applies a uniform force against the breast tissue, holding it securely between the flat plate and a biopsy grid. The device can be used with different types of breast coils and offers multiple options for compression, including an expandable insert or an inflatable bladder. The invention aims to improve the stability and uniformity of breast tissue during MRI procedures, enhancing visibility of lesions and reducing patient discomfort. [Extracted from the article]

A recent preprint abstract suggests that spherical nano and micro particles containing magnesium are found exclusively in the vasculature of malignant invasive breast cancers. These particles are not present in healthy breast tissue or benign tumors. The discovery of these particles provides new insights into the characteristics of breast calcification associated with malignant tumors and may lead to a better understanding of breast tumors and their microenvironment. However, it is important to note that this research has not yet undergone peer review. [Extracted from the article]

A new report from the University of Pittsburgh discusses research findings on breast cancer screening. The study focuses on reducing unnecessary breast biopsies by using deep learning algorithms to analyze mammogram images. The researchers developed a classification algorithm that aims to identify benign cases, reduce unnecessary excision of atypia, and provide a precise diagnosis. The study suggests that deep learning of mammograms can potentially lead to a reduction in unnecessary procedures, costs, and stress associated with breast biopsies. [Extracted from the article]

A recent report from Stanford University School of Medicine discusses the use of SCOUT reflectors in breast biopsies. The study found that SCOUT reflectors were utilized for surgery in 64% of cases, despite the majority of biopsies yielding malignant, elevated risk, or benign-discordant results. Factors that increased the utilization of reflectors included smaller lesion size, no suspicious ipsilateral lymph node, and no prior treated breast cancer. This research provides valuable insights into the surgical utilization of SCOUT reflectors in breast biopsy procedures. [Extracted from the article]

A study conducted at Brigham and Women's Hospital in Boston, Massachusetts, has examined the characteristics of lymphocytic lobulitis (LL) in diagnostic breast biopsies. LL is characterized by lymphocytic infiltrates centered on lobules, and there are two types: non-sclerosing LL (NSCLL) and sclerosing LL (SCLL). NSCLL was found to be associated with a significant risk for breast cancer, and it can be detected as a palpable mass or an imaging finding in diagnostic biopsies. The study highlights the importance of pathologists being aware of NSCLL as an indicator of breast cancer risk. [Extracted from the article]

A recent study conducted at Tri-Service General Hospital in Taipei, Taiwan, focused on a case of a 59-year-old Taiwanese woman diagnosed with invasive ductal carcinoma in her right breast. During breast-conserving surgery, the patient developed a rare allergic reaction to the blue dye injected to localize the sentinel lymph nodes. Although her vital signs remained stable, the patient required more time to recover, possibly due to her allergic predisposition. This case highlights the importance of monitoring patients for allergic reactions during surgical procedures. [Extracted from the article]

A recent preprint abstract discusses the development of a near-infrared optical nanosensor for rapid differentiation of estrogen receptor (ER) status in breast cancer biopsy samples. The nanosensor, which uses single-walled carbon nanotubes as the transducer and an anti-ERa antibody as the recognition element, was able to differentiate between ER-positive and ER-negative patient biopsies. This technology has the potential to improve the speed and accuracy of subtyping breast cancer and may have applications in molecular marker profiling. However, it is important to note that this research has not yet undergone peer review. [Extracted from the article]

A clinical trial, NCT06336928, has been launched to determine if a blood analysis called liquid biopsy (LBx) can correlate with mammography results and breast cancer diagnosis. The study aims to assess the sensitivity and specificity of LBx as a screening method for breast cancer by comparing LBx results with pathological diagnoses within one year. The trial is observational, with patients undergoing blood sample collection and medical record review. The study is being conducted by the University of Southern California and is expected to be completed by April 1, 2030. [Extracted from the article]

A recent study conducted by researchers at the University of Illinois Urbana-Champaign explores the use of label-free nonlinear optical microscopy to analyze extracellular vesicles (EVs) in breast cancer. EVs have been linked to metastasis and are considered potential cancer biomarkers, but their small size and heterogeneity make them difficult to study. The researchers examined EVs in ex vivo tissue samples and biofluids from individuals with breast cancer, comparing them to control samples. They found significant differences in the optical metabolic signatures of EVs in cases of malignant breast cancer compared to control samples, suggesting the potential for using EVs as diagnostic markers. [Extracted from the article]

A new study conducted by a researcher at the University of Surrey in the United Kingdom has found that the APIS Breast Cancer Subtyping Kit is highly accurate in assessing breast cancer subtypes. The kit evaluates seven parameters, including three biomarkers commonly assessed in breast cancer cases, as well as four additional genes that create a unique proliferation signature. The study compared the results of the APIS kit with the standard immunohistochemistry (IHC) and/or in situ hybridization (ISH) protocols and found high concordance rates for estrogen receptor (ER), progesterone receptor (PR), and HER-2. The researchers concluded that the APIS kit could be a valuable tool in the routine assessment of newly diagnosed breast cancer specimens. [Extracted from the article]

A study conducted by the University of Colombo in Sri Lanka explores the use of liquid biopsy in breast carcinoma. Liquid biopsy is a non-invasive method of obtaining tumor-derived material from blood and body fluid. The study highlights the potential of liquid biopsy in detecting and monitoring breast carcinoma, including the assessment of circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), tumor educated platelets (TEPs), and exosomes. While there are limitations to its use, liquid biopsy shows promise in personalized cancer care and clinical decision making. [Extracted from the article]

Researchers from Shenyang University of Technology in China have developed a human-size handheld magnetic particle imaging (MPI) system for the detection of sentinel lymph nodes in breast cancer. The system includes a highly sensitive MPI detection probe, concentric coils for spatialization, and a solenoid coil for excitation. The system was able to detect Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in rat experiments, with a detection limit of 30 mm in the Z direction and a spatial resolution of about 5 mm. The researchers plan to perform further experiments and imaging in large mammals and explore the clinical application of the system. [Extracted from the article]

A patent has been issued to Hologic Inc. for a wireless active monitoring implant system. The system involves the use of a wireless biosensor implanted in a breast biopsy cavity to detect biochemical parameter data in real-time. This data is then transmitted to an external monitoring device, which can evaluate the data and monitor trends in the tumor's microenvironment, track treatment progress, and tailor personalized treatments. The system aims to provide a means of monitoring and evaluating real-time information on the effectiveness of breast cancer treatment. [Extracted from the article]

A study conducted by researchers from the University of Kansas evaluated the use of indocyanine green (IcG) as an alternative to isosulfan blue (IB) for sentinel lymph node (SLN) mapping in breast cancer patients. The study found that IcG had improved cost and safety compared to IB. The researchers concluded that surgeons may be able to safely transition from IB to IcG for patients with early-stage breast cancer undergoing surgery first. However, they also emphasized the importance of individuals tracking their own data to confirm the safety of the technique. [Extracted from the article]

A study conducted at Mashhad University of Medical Sciences in Iran investigated the effect of implementing Peplau's model on the sleep quality of women waiting for breast biopsy results. The study involved a randomized clinical trial with an intervention group and a control group. The intervention group received a program based on Peplau's model, which included face-to-face communication and telephone follow-ups, while the control group received conventional care. The results showed a statistically significant difference in sleep quality between the two groups, suggesting that the application of Peplau's model can improve sleep quality in outpatient care settings. [Extracted from the article]

A new report from researchers at Georges Pompidou European Hospital in Paris, France, discusses the use of indocyanine green (ICG) for axillary sentinel lymph node (SLN) detection in early breast cancer. The study found that ICG is at least equivalent to other techniques for SLN detection, but it has not yet been recommended by learned societies in France. The researchers conducted a survey among French breast cancer surgeons and found that over a third of them have been using ICG for 2 to 3 years. The main advantage reported for this method is the reduction of organizational constraints, but obstacles include the need for near infra-red camera equipment and the lack of validation by French guidelines. The researchers conclude that there is a need for French learned societies to take a stand on this issue and for further studies to standardize practices. [Extracted from the article]

A study conducted at Cairo University explored the integration of artificial intelligence (AI) with contrast-enhanced mammograms (CEM) to improve the specificity of breast lesion diagnoses. The AI algorithm analyzed mammograms and provided location information for lesions, assigning a probability of malignancy. The study found that the use of AI in conjunction with CEM significantly increased the sensitivity, negative predictive value, and accuracy of mammogram interpretations. This research suggests that AI can reduce interpretational variability and minimize unnecessary biopsies for suspicious breast lesions. [Extracted from the article]