1. Immune protection-inducing protein structures (IMPIPS) against malaria: the weapons needed for beating Odysseus.
- Author
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Patarroyo ME, Patarroyo MA, Pabón L, Curtidor H, and Poloche LA
- Subjects
- Amino Acid Sequence, Humans, Life Cycle Stages immunology, Peptides chemistry, Peptides metabolism, Plasmodium falciparum immunology, Protein Conformation, Protozoan Proteins physiology, Vaccines, Synthetic chemistry, Malaria Vaccines chemistry, Malaria Vaccines immunology, Malaria, Falciparum prevention & control, Peptides immunology, Protozoan Proteins immunology, Vaccines, Synthetic immunology
- Abstract
The review covers the functional and structural approach followed by our group for more than 34 years in the search for a methodology that allows the rational design of chemically synthesised vaccines. An analogy between Odysseus, the cunning hero of the epic poem Odyssey by Homer, and the elusive Plasmodium parasite has been made, to review our research group's main considerations when developing a rational methodology for designing second generation, modified peptide-based, minimal subunit, multi-antigen, multi-stage, chemically synthesised vaccines against Plasmodium falciparum malaria., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2015
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