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Immune protection-inducing protein structures (IMPIPS) against malaria: the weapons needed for beating Odysseus.
- Source :
-
Vaccine [Vaccine] 2015 Dec 22; Vol. 33 (52), pp. 7525-37. Date of Electronic Publication: 2015 Oct 19. - Publication Year :
- 2015
-
Abstract
- The review covers the functional and structural approach followed by our group for more than 34 years in the search for a methodology that allows the rational design of chemically synthesised vaccines. An analogy between Odysseus, the cunning hero of the epic poem Odyssey by Homer, and the elusive Plasmodium parasite has been made, to review our research group's main considerations when developing a rational methodology for designing second generation, modified peptide-based, minimal subunit, multi-antigen, multi-stage, chemically synthesised vaccines against Plasmodium falciparum malaria.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Amino Acid Sequence
Humans
Life Cycle Stages immunology
Peptides chemistry
Peptides metabolism
Plasmodium falciparum immunology
Protein Conformation
Protozoan Proteins physiology
Vaccines, Synthetic chemistry
Malaria Vaccines chemistry
Malaria Vaccines immunology
Malaria, Falciparum prevention & control
Peptides immunology
Protozoan Proteins immunology
Vaccines, Synthetic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 33
- Issue :
- 52
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 26469723
- Full Text :
- https://doi.org/10.1016/j.vaccine.2015.09.109