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Start Over Author "Adegbola, Richard A" Journal the pediatric infectious disease journal
22 results on '"Adegbola, Richard A"'

5. Etiology of serious infections in young Gambian infants

Author

MULHOLLAND, E. KIM, primary, OGUNLESI, OLAYINKA O., additional, ADEGBOLA, RICHARD A., additional, WEBER, MARTIN, additional, SAM, BENJAMIN E., additional, PALMER, AYO, additional, MANARY, MARK J., additional, SECKA, OUSMAN, additional, AIDOO, MICHAEL, additional, HAZLETT, DANIEL, additional, WHITTLE, HILTON, additional, and GREENWOOD, BRIAN M., additional

Published
1999
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6. A polymerase chain reaction for the diagnosis of Haemophilus influenzae type b disease in children and its evaluation during a vaccine trial

Author

HASSAN-KING, MUSA, primary, ADEGBOLA, RICHARD, additional, BALDEH, IGNATIUS, additional, MULHOLLAND, KIM, additional, OMOSIGHO, CHARLES, additional, OPARAUGO, ANSLEM, additional, USEN, STANLEY, additional, PALMER, AYO, additional, SCHNEIDER, GISELA, additional, SECKA, OUSMAN, additional, WEBER, MARTIN, additional, and GREENWOOD, BRIAN, additional

Published
1998
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7. The clinical spectrum of respiratory syncytial virus disease in The Gambia

Author

WEBER, MARTIN W., primary, DACKOUR, RADUWAN, additional, USEN, STANLEY, additional, SCHNEIDER, GISELA, additional, ADEGBOLA, RICHARD A., additional, CANE, PATRICIA, additional, JAFFAR, SHABBAR, additional, MILLIGAN, PAUL, additional, GREENWOOD, BRIAN M., additional, WHITTLE, HILTON, additional, and MULHOLLAND, E. KIM, additional

Published
1998
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8. Epidemiology of invasive pneumococcal disease in the Western Region, The Gambia

Author

USEN, STANLEY, primary, ADEGBOLA, RICHARD, additional, MULHOLLAND, KIM, additional, JAFFAR, SHABBAR, additional, HILTON, STEPHEN, additional, OPARAUGO, ANSLEM, additional, OMOSIGHO, CHARLES, additional, LAHAI, GEORGE, additional, CORRAH, TUMANI, additional, PALMER, AYO, additional, SCHNEIDER, GISELA, additional, WEBER, MARTIN, additional, and GREENWOOD, BRIAN, additional

Published
1998
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9. A randomized trial of chloramphenicol vs. trimethoprim-sulfamethoxazole for the treatment of malnourished children with community-acquired pneumonia

Author

MULHOLLAND, E. KIM, primary, FALADE, ADEGOKE G., additional, CORRAH, P. TUMANI, additional, OMOSIGHO, CHARLES, additional, NʼJAI, PAMELA, additional, GIADOM, BARRY, additional, ADEGBOLA, RICHARD A., additional, TSCHÄPPELER, HEINZ, additional, TODD, JAMES, additional, and GREENWOOD, BRIAN M., additional

Published
1995
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13. Commercial Interferon Gamma Release Assays Compared to the Tuberculin Skin Test for Diagnosis of Latent Mycobacterium tuberculosisInfection in Childhood Contacts in the Gambia

Author

Adetifa, Ifedayo M. O., Ota, Martin O. C., Jeffries, David J., Hammond, Abdulrahman, Lugos, Moses D., Donkor, Simon, Patrick, Owiafe, Adegbola, Richard A., and Hill, Philip C.

Abstract

We compared the performance of tuberculin skin test (TST), Quantiferon-TB Gold in-tube (QFT-GIT), and T-SPOT.TBin diagnosing latent tuberculosis (LTBI) among childhood TB contacts in a TB endemic setting with high BCG coverage. We evaluated the performance of interferon gamma release assays (IGRAs) and TST when combined in an algorithm.

Published
2010
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14. Nasopharyngeal Carriage of Streptococcus pneumoniaein Gambian Children who Participated in a 9-valent Pneumococcal Conjugate Vaccine Trial and in Their Younger Siblings

Author

Cheung, Yin-Bun, Zaman, Syed M. A., Nsekpong, Ekpedeme David, Beneden, Chris A. Van, Adegbola, Richard A., Greenwood, Brian, and Cutts, Felicity T.

Abstract

Nasopharyngeal carriage of Streptococcus pneumoniaeis extremely prevalent in The Gambia. We studied the effects of vaccination with pneumococcal conjugate vaccines on the carriage of individual serotypes and on antimicrobial resistance in vaccinated children and their younger siblings.

Published
2009
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15. Epidemiologic and Clinical Characteristics of Community-Acquired Invasive Bacterial Infections in Children Aged 2–29 Months in The Gambia

Author

Enwere, Godwin, Biney, Ekow, Cheung, YinBun, Zaman, Syed M. A., Okoko, Brown, Oluwalana, Claire, Vaughan, Adeola, Greenwood, Brian, Adegbola, Richard, and Cutts, Felicity T.

Abstract

The incidence of community-acquired bacteremia (CAB) in Africa is several-fold higher than in industrialized countries. We report here the incidence of invasive bacterial infections in rural Gambia and compare the clinical characteristics of children with pneumococcal infection with those of children with extraintestinal nontyphoidal salmonella infection (NTS) or other bacterial infections.

Published
2006
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16. Safety and immunogenicity of a nonavalent pneumococcal vaccine conjugated to CRM197administered simultaneously but in a separate syringe with diphtheria, tetanus and pertussis vaccines in Gambian infants

Author

OBARO, STEVEN K., ADEGBOLA, RICHARD A., CHANG, I H, BANYA, WINSTON A. S., JAFFAR, SHABBAR, MCADAM, KEITH W. J. P., and GREENWOOD, BRIAN M.

Abstract

Unrelenting high morbidity and mortality have mandated that immunogenic vaccines be used to combat pneumococcal disease in infants.

Published
2000

17. A randomized trial of chloramphenicol vstrimethoprimsulfamethoxazole for the treatment of malnourished children with communityacquired pneumonia

Author

MULHOLLAND, E. KIM, FALADE, ADEGOKE G., CORRAH, P. TUMANI, OMOSIGHO, CHARLES, N'JAI, PAMELA, GIADOM, BARRY, ADEGBOLA, RICHARD A., TSCHÄPPELER, HEINZ, TODD, JAMES, and GREENWOOD, BRIAN M.

Abstract

Children in developing countries who present with malnutrition often have infections, particularly pneumonia, at the time of presentation. We evaluated the initial antibiotic management of 144 Gambian children who presented for the first time with malnutrition and who had clinical or radiologic evidence of pneumonia. They were enrolled in a double blind trial of trimethoprim-sulfamethoxazole vs.chloramphenicol. Most children in the study underwent detailed investigations of bacterial and viral etiology as part of another study. The study drug was administered for a week along with oral metronidazole, vitamins and standardized nutritional therapy. Treatment failure was defined as the need for change to parenteral antibiotics during treatment, failure to respond to a week of treatment with the study drug or relapse during the following 2 weeks. There were no differences between the treatment groups in the clinical indicators of severity, etiology or radiologic findings. Thirty-three children were excluded from the analysis because of tuberculosis, inappropriate enrollment or inadequate follow-up. Of the 111 children remaining, 32 (16 in each arm of the study) failed treatment. Clinical failure was not related…

Published
1995

18. The etiology of pneumonia in malnourished and wellnourished Gambian children

Author

ADEGBOLA, RICHARD A., FALADE, ADEGOKE G., SAM, BENJAMIN E., AIDOO, MICHAEL, BALDEH, IGNATIUS, HAZLETT, DANIEL, WHITTLE, HILTON, GREENWOOD, BRIAN M., and MULHOLLAND, E. KIM

Abstract

During a 2-year period 159 malnourished children ages 3 months to 5 years with radiologic evidence of pneumonia were investigated to determine the cause of their pneumonia. In addition 119 malnourished children without pneumonia, 119 well-nourished children with pneumonia and 52 well-nourished children without pneumonia were studied as controls. Percutaneous lung aspiration was performed on 35 malnourished and 59 well-nourished children with pneumonia. Bacteria were isolated from the blood, lung or pleural fluid of 28 (18) malnourished children with pneumonia, 42 (35) well-nourished children with pneumonia and from the blood of 5 (4) malnourished children without pneumonia. Streptococcus pneumoniaeand Haemophilus influenzae,which were the two organisms isolated most frequently in both groups of children with pneumonia, were found in 17 (11) malnourished and 39 (33) well-nourished children with pneumonia. Mycobacterium tuberculosiswas detected in 5 malnourished children with pneumonia. A potentially pathogenic virus was identified in 35 of malnourished children with pneumonia and 40 of well-nourished children with pneumonia, and from 25 of children without pneumonia. The viruses identified most frequently were adenovirus and respiratory syncytial virus. There were 26 viral isolates from lung aspirate specimens. Respiratory syncytial virus was more frequently isolated from well-nourished children, while herpes simplex was more often found in malnourished children. Both bacterial and viral agents were identified in 25 children. In situations where measles and kwashiorkor are uncommon, the likely bacterial causes of community-acquired pneumonia in both well-nourished and malnourished children are S. pneumoniaeand H. influenzaebut, in malnourished children, particularly those with edema, the possibility of other causes, particularly M. tuberculosis,must always be kept in mind.

Published
1994

19. A polymerase chain reaction for the diagnosis of Haemophilus influenzaetype b disease in children and its evaluation during a vaccine trial

Author

HASSAN-KING, MUSA, ADEGBOLA, RICHARD, BALDEH, IGNATIUS, MULHOLLAND, KIM, OMOSIGHO, CHARLES, OPARAUGO, ANSLEM, USEN, STANLEY, PALMER, AYO, SCHNEIDER, GISELA, SECKA, OUSMAN, WEBER, MARTIN, and GREENWOOD, BRIAN

Abstract

Determination of the etiology of pneumonia in young children is difficult because blood culture, the usual method of diagnosis, is positive in only a small proportion of cases. For this reason vaccine trials that include bacterial pneumonia as an endpoint must be large.

Published
1998

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