1. Significance of Non-phase Locked Oscillatory Brain Activity in Response to Noxious Stimuli
- Author
-
Raphaël Dufort Rouleau, Kevin Whittingstall, Philippe Goffaux, Guillaume Léonard, Lydia Lagrandeur, Dominique Lorrain, and Kathya Daigle
- Subjects
Adult ,Male ,Brain activity and meditation ,Pain ,Stimulation ,Neuroimaging ,Electroencephalography ,Brain mapping ,Young Adult ,Noxious stimulus ,medicine ,Humans ,Neurons ,Brain Mapping ,medicine.diagnostic_test ,Brain ,General Medicine ,Human brain ,Electric Stimulation ,Dorsolateral prefrontal cortex ,medicine.anatomical_structure ,Neurology ,Female ,Neurology (clinical) ,Psychology ,Neuroscience - Abstract
Background: Although current pain-evoked electroencephalographic (EEG) studies provide valuable information regarding human brain regions involved in pain, they have mostly considered neuronal responses which oscillate in phase following a painful event. In many instances, cortical neurons respond by generating bursts of activity that are slightly out of phase from trial-to-trial. These types of activity bursts are known as induced brain responses. The significance of induced brain responses to pain is still unknown. Methods: In this study, 23 healthy subjects were given both non-painful and painful transcutaneous electrical stimulations in separate testing blocks (stimulation strength was kept constant within blocks). Subjective intensity was rated using a numerical rating scale, while cerebral activity tied to each stimulation was measured using EEG recordings. Induced brain responses were identified using a time frequency wavelet transform applied to average-removed single trials. Results: Results showed a pain-specific burst of induced theta activity occurring between 180 and 500 ms post-shock onset. Source current density estimations located this activity within the dorsolateral prefrontal cortex (DLPFC, bilaterally), however, only right DLPFC activity predicted a decrease in subjective pain as testing progressed. Conclusion: This finding suggests that non-phase locked neuronal responses in the right DLPFC contribute to the endogenous attenuation of pain through time. Perspective: This article presents neuroimaging findings demonstrating that, in response to pain, non-phase locked bursts of theta activity located in the right dorsolateral prefrontal cortex are associated with a progressive decrease in subjective pain intensity, which has potentially important implications regarding how humans endogenously control their experiences of pain.
- Published
- 2015