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Significance of Non-phase Locked Oscillatory Brain Activity in Response to Noxious Stimuli
- Source :
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. 42(6)
- Publication Year :
- 2015
-
Abstract
- Background: Although current pain-evoked electroencephalographic (EEG) studies provide valuable information regarding human brain regions involved in pain, they have mostly considered neuronal responses which oscillate in phase following a painful event. In many instances, cortical neurons respond by generating bursts of activity that are slightly out of phase from trial-to-trial. These types of activity bursts are known as induced brain responses. The significance of induced brain responses to pain is still unknown. Methods: In this study, 23 healthy subjects were given both non-painful and painful transcutaneous electrical stimulations in separate testing blocks (stimulation strength was kept constant within blocks). Subjective intensity was rated using a numerical rating scale, while cerebral activity tied to each stimulation was measured using EEG recordings. Induced brain responses were identified using a time frequency wavelet transform applied to average-removed single trials. Results: Results showed a pain-specific burst of induced theta activity occurring between 180 and 500 ms post-shock onset. Source current density estimations located this activity within the dorsolateral prefrontal cortex (DLPFC, bilaterally), however, only right DLPFC activity predicted a decrease in subjective pain as testing progressed. Conclusion: This finding suggests that non-phase locked neuronal responses in the right DLPFC contribute to the endogenous attenuation of pain through time. Perspective: This article presents neuroimaging findings demonstrating that, in response to pain, non-phase locked bursts of theta activity located in the right dorsolateral prefrontal cortex are associated with a progressive decrease in subjective pain intensity, which has potentially important implications regarding how humans endogenously control their experiences of pain.
- Subjects :
- Adult
Male
Brain activity and meditation
Pain
Stimulation
Neuroimaging
Electroencephalography
Brain mapping
Young Adult
Noxious stimulus
medicine
Humans
Neurons
Brain Mapping
medicine.diagnostic_test
Brain
General Medicine
Human brain
Electric Stimulation
Dorsolateral prefrontal cortex
medicine.anatomical_structure
Neurology
Female
Neurology (clinical)
Psychology
Neuroscience
Subjects
Details
- ISSN :
- 03171671
- Volume :
- 42
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
- Accession number :
- edsair.doi.dedup.....b168ba374c9f75fc882671114a4a1baf