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Your search keyword '"Nathalie Thieriet"' showing total 3 results
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3 results on '"Nathalie Thieriet"'

1. Tandem deprotection-coupling of Nα-Alloc-amino acids by use of ternary systems Pd cat./PhSiH3/carboxy-activated amino acid

Author

Paloma Gomez-Martinez, François Guibé, and Nathalie Thieriet

Subjects
inorganic chemicals, chemistry.chemical_classification, Stereochemistry, Organic Chemistry, chemistry.chemical_element, Peptide, Biochemistry, Catalysis, Amino acid, Acylation, chemistry.chemical_compound, chemistry, Phenylsilane, Drug Discovery, Organic chemistry, Triphenylphosphine, Ternary operation, Palladium
Abstract

Nα-allyloxycarbonyl derivatives of amino acids undergo smooth coupling with various carboxy-activated partners when treated with phenylsilane (PhSiH3) in the presence of catalytic amounts of tetrakis-(triphenylphosphine) palladium.

Published
1999
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2. Use of Alloc-amino acids in solid-phase peptide synthesis. Tandem deprotection-coupling reactions using neutral conditions

Author

Ernest Giralt, Fernando Albericio, Jordi Alsina, Nathalie Thieriet, and François Guibé

Subjects
chemistry.chemical_classification, Tandem, Stereochemistry, Organic Chemistry, Side reaction, Biochemistry, Coupling reaction, Scavenger (chemistry), Amino acid, Catalysis, chemistry.chemical_compound, chemistry, Phase (matter), Drug Discovery, Peptide synthesis
Abstract

The use of Alloc group in SPPS for the Nα protection of amino acids is an alternative to the Boc and Fmoc protecting groups. The smooth removal of Alloc group in neutral conditions with catalytic amounts of Pd(PPh3)4 in the presence of PhSiH3 as a scavenger for the allyl system permits orthogonality with the most common protecting groups. Furthermore, a tandem deprotection-coupling reaction allows the suppression of DKP formation in cases where this side reaction is troublesome.

Published
1997
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3. New allyl group acceptors for palladium catalyzed removal of allylic protections and transacylation of allyl carbamates

Author

Nathalie Thieriet, Albert Loffet, Michèle Dessolin, Marie-George Guillerez, and François Guibé

Subjects
N-methyl-N-(trimethylsilyl)trifluoroacetamide, Allylic rearrangement, Trimethylsilyl, Organic Chemistry, chemistry.chemical_element, Biochemistry, Catalysis, chemistry.chemical_compound, Transacylation, chemistry, Drug Discovery, Organic chemistry, Palladium catalyst, Palladium
Abstract

Allyl carboxylates, carbamates and phenoxides may be cleaved or transacylated in the presence of palladium catalyst and either phenyltrihydrosilane or N-methyl-N-(trimethylsilyl)-trifluoroacetamide. These reactions are totally compatible with the presence of Boc and, as far as phenyltrihydrosilane is concerned, Fmoc protections.

Published
1995
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