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Abstract: A simple and efficient protocol for the anti-Markovnikov addition of thiols to vinyl ethers under solvent- and catalyst-free conditions has been established. A series of thiol ethers containing oxygen atom were obtained with good to excellent yields. [Copyright &y& Elsevier]

Abstract: A novel and efficient enzymatic promiscuous protocol for aza-Michael addition of aromatic N-heterocycles to α,β-unsaturated compounds has been described. The reactions were catalyzed by promiscuous zinc-active-site acylase in organic solvent at 50°C. The strategy works with a broad range of N-heterocycles to afford the corresponding Michael adduct with good yields in several hours (0.5–6h). This catalytic promiscuity is the first example of metal-active-site enzyme-catalyzed aza-Michael addition for aromatic N-heterocycles. [Copyright &y& Elsevier]

Abstract: A novel and highly efficient protocol for Markovnikov’s addition using ionic liquid as a catalytic green solvent is described. The strategy is especially useful in the synthesis of N-heterocycle derivatives with biological activity. This reaction widens largely the applicability of ionic liquid in organic synthesis. [Copyright &y& Elsevier]