Back to Search
Start Over
Promiscuous acylase-catalyzed aza-Michael additions of aromatic N-heterocycles in organic solvent
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Aug2007, Vol. 48 Issue 35, p6100-6104. 5p. - Publication Year :
- 2007
-
Abstract
- Abstract: A novel and efficient enzymatic promiscuous protocol for aza-Michael addition of aromatic N-heterocycles to α,β-unsaturated compounds has been described. The reactions were catalyzed by promiscuous zinc-active-site acylase in organic solvent at 50°C. The strategy works with a broad range of N-heterocycles to afford the corresponding Michael adduct with good yields in several hours (0.5–6h). This catalytic promiscuity is the first example of metal-active-site enzyme-catalyzed aza-Michael addition for aromatic N-heterocycles. [Copyright &y& Elsevier]
- Subjects :
- *ORGANIC solvents
*ORGANIC compounds
*CHEMICAL bonds
*ORGANIC chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 48
- Issue :
- 35
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26036264
- Full Text :
- https://doi.org/10.1016/j.tetlet.2007.06.164