1. Synthesis of the C1–C13 fragment of eribulin mesylate
- Author
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Jooyoung Song, In-Soo Myeong, Eunim Jung, Chang Heon Suhl, Seunghui Sin, Hyoungwook Moon, Soo Hwan Yoon, Hyunik Shin, Eunjung Ko, Kee-Young Lee, Jaehun Jung, Chang-Young Oh, Heesun Jung, Junkyu Lee, Yunkyung Jung, Wonjae Kang, Yongseo Park, Seong Take Kim, and Hyoseon Lee
- Subjects
Eribulin Mesylate ,Sharpless epoxidation ,Olefin metathesis ,010405 organic chemistry ,Fragment (computer graphics) ,Chemistry ,Stereochemistry ,Organic Chemistry ,Regioselectivity ,010402 general chemistry ,Ring (chemistry) ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Drug Discovery ,Stereoselectivity - Abstract
Synthesis of the C1–C13 fragment of eribulin mesylate has been accomplished. It features a highly stereoselective construction of a trans-dihydropyran framework using three key reactions: (1) Sharpless epoxidation, (2) regioselective ring opening, and (3) olefin metathesis.
- Published
- 2019