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1. Liquid chromatography tandem mass spectrometry in study of the pharmacokinetics of six steroidal saponins in rats.

Author

Wang, Benwei, Ji, Songgang, Zhang, Hai, Zhao, Liang, Lv, Lei, Li, Yueyue, Zhou, Guichen, and Zhang, Guoqing

Subjects
*LIQUID chromatography-mass spectrometry, *PHARMACOKINETICS, *SAPONINS, *STEROIDS, *SOLVENT extraction, *LABORATORY rats
Abstract

Highlights: [•] We developed and validated a novel quantification method using HPLC–MS/MS. [•] It is for the first time we simultaneous determined six main steroidal saponins in Paris polyphylla in vivo. [•] We report the pharmacokinetics parameters of steroidal saponins in rat for the first time. [•] We report the steroidal saponins have a long MRT and low concentration. [•] We introduced the Accelerated Solvent Extraction in sample preparation. [ABSTRACT FROM AUTHOR]

Published
2013
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