1. Induction of antigen cross-presentation by Toll-like receptors.
- Author
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Datta, Sandip and Raz, Eyal
- Subjects
- *
DENDRITIC cells , *MAJOR histocompatibility complex , *ANTIGENS , *T cells , *LYMPHOID tissue , *LYMPHOCYTES - Abstract
Cross-presentation is the pathway by which exogenous antigens are routed for presentation on MHC class I for activation of CD8+ T cells. This pathway is important for the development of CD8+ cytotoxic T lymphocyte responses against tumors and infectious pathogens that do not directly infect APC. We review studies showing that certain Toll-like receptors mediate cross-presentation by dendritic cells, initiating cytosolic processing of antigen after inducing dendritic cell maturation. The implications of these studies for understanding CD8+ T cell activation and implementing novel vaccine strategies is considered. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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