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Induction of antigen cross-presentation by Toll-like receptors.
- Source :
-
Springer Seminars in Immunopathology . Jan2005, Vol. 26 Issue 3, p247-255. 9p. - Publication Year :
- 2005
-
Abstract
- Cross-presentation is the pathway by which exogenous antigens are routed for presentation on MHC class I for activation of CD8+ T cells. This pathway is important for the development of CD8+ cytotoxic T lymphocyte responses against tumors and infectious pathogens that do not directly infect APC. We review studies showing that certain Toll-like receptors mediate cross-presentation by dendritic cells, initiating cytosolic processing of antigen after inducing dendritic cell maturation. The implications of these studies for understanding CD8+ T cell activation and implementing novel vaccine strategies is considered. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03444325
- Volume :
- 26
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Springer Seminars in Immunopathology
- Publication Type :
- Academic Journal
- Accession number :
- 15416848
- Full Text :
- https://doi.org/10.1007/s00281-004-0174-2