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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的　总结播散性堪萨斯分枝杆菌病的临床特征及有效诊治方法。方法　对1例播散性堪萨斯分枝杆 菌病患者的临床资料作回顾性分析。结果　患者主要临床表现为反复发热、全身多发淋巴结肿大，胸部影像学检查 可见双下肺实变伴不张，双侧胸腔积液、心包积液，痰液涂片和左侧锁骨上淋巴结抗酸染色阳性，右侧大腿背侧皮下 肿块穿刺液16S rRNA检测结果堪萨斯分枝杆菌阳性，结合患者临床症状明确诊断为播散性堪萨斯分枝杆菌病。予 四联（利福平、异烟肼、乙胺丁醇、克拉霉素）抗非结核分枝杆菌（NTM）药物治疗8周，疗效较好。结论　播散性堪萨 斯分枝杆菌病主要临床表现为反复发热、全身淋巴结肿大、皮肤包块及皮下结节。临床症状、抗酸杆菌检查阳性结 合皮下结节穿刺液 16S rRNA检测结果可明确诊断播散性堪萨斯分枝杆菌病，抗 NTM 药物治疗播散性堪萨斯分枝 杆菌病效果较好。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 总结新生儿期发病的氨甲酰磷酸合成酶1缺乏症（CPS1D）的诊断方法。方法 对1例新生儿期发 病的CPS1D患儿的临床资料作回顾性分析。结果 患儿女，出生第3天表现为发热、反应低下、嗜睡及血氨水平升 高。患儿 CPS1基因存在复合杂合突变，分别为第 19号外显子 chr2：211473230位置 c. 2238C>T（p. R780C），可导致 第780位氨基酸由精氨酸突变为半胱氨酸；第3号外显子chr2：211441171位置c. 338A>T（P. D113V），可导致第113 位氨基酸由天冬氨酸突变为缬氨酸。患儿母亲存在 CPS1基因第 19号外显子 chr2：211473230位置 c. 2238C>T（p. R780C）变异，患儿父亲存在第 3号外显子 chr2：211441171位置 c. 338A>T（P. D113V）变异。根据临床表现、实验室 检查及基因检测结果，患儿明确诊断为 CPS1D。结论 新生儿期发病的 CPS1D患儿主要临床表现为反应低下、意 识障碍、血氨水平升高，患儿存在 CPS1 基因第 19 号外显子 chr2：211473230 位置 c. 2238C>T（p. R780C）、c. 338A>T （P. D113V）复合杂合突变，患儿CPS1基因复合杂合突变分别遗传自患儿父、母。血、尿氨基酸实验室检查联合基因 检测可明确CPS1D诊断. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationships between serum autophagy-related protein 9a（ATG9a）and melatonin（MLT）levels and left ventricular hypertrophy（LVH）in hypertension patients. Methods Totally 157 hypertensive patients，including 77 cases with LVH（LVH group）and 80 cases without LVH（control group), were selected. Serum ATG9a and MLT levels were detected. Binary Logistic stepwise regression analysis was used to analyze the correlations between ATG9a and MLT and LVH in patients with hypertension. The value of ATG9a and MLT in diagnosing hypertension complicated with LVH was analyzed by receiver operating characteristic（ROC）curve. Results The serum ATG9a level of the LVH group was higher than that of the control group（P<0. 05), and the serum MLT level was lower than that of the control group（P<0. 05). Logistic binary stepwise regression analysis showed that high systolic blood pressure, high ATG9a，high FPG，and low MLT were risk factors for LVH in hypertensive patients（all P<0. 01). ROC curve analysis results showed that the area under the curve（AUC）of ATG9a，MLT，combined ATG9a and MLT in the diagnosis of hypertensive patients with LVH were 0. 719，0. 806，and 0. 912，respectively，with the sensitivities of 75. 32%, 80. 52%，and 89. 61%，and the specificities of 77. 50%，81. 25%，and 90. 00%，respectively. Conclusion In patients with hypertension complicated with LVH，serum ATG9a increases，MLT decreases，and high ATG9a and low MLT are risk factors for hypertension complicated with LVH. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 系统评价消渴方加减联合二甲双呱治疗2 型糖尿病( T2DM ) 的疗效。方法计算机检索PubMed、 Embase、The Cochrane Library、中国知网、万方数据库、中国生物医学文献数据库和维普数据库， 收集消渴方加减联合 二甲双呱治疗T2DM 的随机对照研究， 检索时限从建库至2019 年1 1 月。根据制定的纳入和排除标准对收集的文献 进行严格筛选， 采用Cochrane 协作网偏倚风险评估工具对纳入的研究进行质量评价， 使用Rev Man5. 3 软件对结局指 标进行Meta 分析。结果初步检索共获得345 篇相关文献， 最终纳入定量Meta 分析文献8 篇； 8 篇文献共计818 例 患者， 其中观察组409 例、对照组409 例。Meta 分析结果显示， 冶疗后观察组总有效率高于对照组( RR = 1. 28,95% CI 1 . 19 - 1 . 38, P < 0. 000 01 ) ， 观察组空腹血糖( MD = - l . 08, 95% CI - l . 70 - 0. 45, P = 0. 000 7 ) 、餐后2 h 血糖 ( MD = - 1 . 31,95% CI - 1 . 94 - - 0. 69, P < 0 . 000 1 ) 、糖化血红蛋自( MD = - 0. 83, 95% CI - 1 . 67 - 0. 01, P = 0. 05 ) 均低于对照组。结论消渴方加减联合二甲双呱治疗T2DM 较单用二甲双呱疗效更好。 [ABSTRACT FROM AUTHOR]

目的 覬察IgA 贤病患者尿外泌体、腎胜組組中B淋巴细胞刺激因子(BAFF)的表迏変化，分析其与病 悄严重程度的美系。 方法 逃取原岌性IgA 腎病患者60例(IgA 腎病組)，其中督胜病理Katafuchi积分0~3分1 7 例、4~6分19例、7~9分15例、10~ 12分9例；造拌因贤胂瘤行手禾治庁的患者20例为対照組。 提取两組尿外泌 体，采用ELISA法检測BAFF。 IgA 贤病組留取病督組組、対照組留取瘤旁正常贤組組，采用免疫組化法检測BAFF。 采用Pearson相美分析法分析尿外泌体、贤胜組組中BAFF表迏与Katafuchi积分、血胆崮醇、24 h尿蛋白、內生肌酐 清除率的相美性，分析尿外泌体与腎胜組組中BAFF表迏的相美性。 結果 IgA 腎病組尿外泌体及贤胜組組中 BAFF表迏均高于対照組(P均<0.05); IgA 腎病組中Katafuchi积分0~3分、4~6分、7 ~9分、10~ 12分的患者尿 外泌体及賢胜組組中 BAFF表迏逐漸增高，两两相比，P均<0.0 5。 IgA 督病組尿外泌体中BAFF水平与Katafuchi 积分(r=0.71)及24 h蛋白尿(r= 0. 67)呈正相美(P均 <0 .05)，与內生肌酐清除率呈負相美(r= -0.78,P< 0.05)。 IgA 腎病組贤胜組組中 BAFF表迏与Katafuchi积分呈正相美(r= 0. 76,P <0. 05)。 IgA 贤病組尿外泌体 BAFF水平与贤胜組組BAFF相対表迏量呈正相美(r= 0. 61,P <0. 05)。 結讠令 IgA 腎病患者尿外泌体及腎胜組組 中BAFF表迏均明昱升高，尿外泌体及贤胜組組中BAFF表迏超势具有一致性，且与病悄严重程度相美。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To analyze ihe trend and hot spots of worldwide research on radiosensitivity of head and neck squamous cell carcinoma (HNSCC), and to provide information support for researchers to carry out relevant scientific research further. Methods Firstly, the articles on radiosensitivity of head and neck carcinoma were retrieved in PubMed. then the relevant articles on radiosensitivity of IINSCC were screened out according to inclusion and exclusion criteria. By the quantitative and co-word biclustering method, the annual amount of articles, core journals and hot topics were analyzed in this field. Results A total of 1 117 related papers were retrieved. Since 1980.the amount of articles on IINSCC radiosensitivity showed an exponential increasing trend. There were 11 core journals in this field, of which, the international journal of radiation oncology, biology, physics published the largest number of relevant publications. The hot research topics in this field mainly include; (1) radiosensitivity of nasopharyngeal carcinoma, (2) radiosensitization associated with epidermal growth factor receptor (EGFR), (3) radiosensitizers of the IINSCC, (4) prediction of HNSCC radiosensitivity by tumor biomarkers, (5) metabolism of IINSCC radiosensitivity, (6)radiosensitivity of esophageal squamous carcinoma, and (7) genetic mechanism underlying the IINSCC radiosensitivity. Conclusions In the recent years, the research on IINSCC radiosensitivity has entered a stage of accelerated development. The HNSCC radiosensitivity is mainly explored from the perspective of genetics and metabolism. The major tumors involved are nasopharyngeal carcinoma and esophageal squamous cell carcinoma. The mechanism and application of radiosensitizers is also an important hot spot. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的观察益气活血、通阳泄浊自拟方辅助治疗冠心病(CHD)伴颈动脉斑块并发慢性心力衰竭(CHF)的临床疗效。方法将80例CHD伴颈动脉斑块并发CHF患者按随机数字表法分为观察组和对照组各40例,均给予常规西医治疗,观察组另予益气活血、通阳泄浊自拟方口服,疗程3个月。治疗前后,比较两组中医症候积分、心功能相关指标、血脂水平及颈动脉内膜中层厚度(IMT)变化,评价两组治疗后的临床疗效。结果治疗前,两组各项指标比较差异均无统计学意义。治疗后,两组主证、次证及总积分较治疗前降低,且观察组低于对照组(P均<0. 05);两组左心室射血分数(LEVF)、每博输出量(SV)较治疗前升高而左心室舒张末期内径(LEVDD)较治疗前降低,且观察组LEVF、SV高于对照组而LEVDD低于对照组(P均<0. 05);两组外周血总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白(LDL-C)及颈动脉IMT较治疗前降低,且观察组低于对照组(P均<0. 05)。观察组治疗总有效率为85. 00%,高于对照组的63. 50%(P <0. 05)。结论益气活血、通阳泄浊自拟方有助于改善CHD伴颈动脉斑块并发CHF患者的症状及心功能,降低血脂水平,提高临床疗效。 [ABSTRACT FROM AUTHOR]

目 的 探讨麻醉诱导前或手术结束前静脉注射纳布啡对老年胃 癌手术患者全麻苏醒期应激反应及炎症 细胞因子水平的影响。 方法 选取择期行全麻胃 癌根治术治疗的老年胃癌患者 92 例 ，将患者随机分为 A组32 例、B组30 例和C组30 例。 A 组在麻醉诱导前静脉注射纳布啡， B 组在手术结束前 10 min 静脉注射纳布啡， C 组 不给予纳布啡；记录三组手术时间、麻醉药物用量、苏醒时间 ，检测麻醉诱导前(T0 汃拨管时(T1 ) 、拔管后 5 min （飞） 血清应激反应指标（血糖、皮质醇、肾上腺索） 和炎症细胞因子(TNF-α、IL-6 、CRP) 。 结果 三组手术时f卧丙 泊酚用量和瑞芬太尼用量差异无统计学意义；B 组苏醒时间和 Ramsay 评分均高于 A 组和C组(P 均 < 0. 05) ;A组 和B组T1 、飞 时血糖、皮质醇和肾上腺索水平均低于 C 组，TNF-α、IL-6 、CRP 水平均低于 C 组(P 均 <0. 05) ； 三组 不 良反应发生率差异无统计学意义。 结论 老年胃癌患者手术中静脉注射纳布啡可抑制应激反应及炎症细胞因 子释放、不增加不良反应，且麻醉诱导前应用较手术结束前应用不延长患者苏醒时间。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

要：目的　总结成人急性淋巴细胞白血病院内感染病原菌分布和耐药情况，并找出院内感染的危险因素。 方法　回顾性分析５２ 例接受化疗的成人急性淋巴细胞白血病患者的痰液及其他分泌物培养结果、药敏试验结果， 并采用单因素分析及Logistic 回归分析成人急性淋巴细胞感染患者化疗期间院内感染的危险因素。结果　52 例成 人急性淋巴细胞白血病患者接受化疗共109 例次，发生院内感染67 例次 (61.46%)。成人急性淋巴细胞白血病患 者分泌物培养获得病原菌 36 株，阳性率为 57.14% (36/63)，包括革兰阴性菌 20 株（以肺炎克雷杆菌及大肠埃希菌 为主）、革兰阳性菌１０ 株（以草绿色链球菌、表皮葡萄球菌及溶血性链球菌为主）、真菌6 株（以白色念珠菌为主）。 其中，革兰阴性菌对青霉素类及头孢类抗菌药物普遍耐药，对碳青霉烯类抗菌药物普遍敏感。住院时间超过28d、 白细胞数目、中性粒细胞数目、粒缺持续时间、白蛋白、前白蛋白、D-二聚体、血小板、血红蛋白及疾病是否获得完全 缓解与成人急性淋巴细胞白血病患者化疗期间发生院内感染有关 (P 均<0.05)。白细胞数、白蛋白水平及疾病是 否获得完全缓解是成人急性淋巴细胞白血病患者化疗期间发生院内感染的独立危险因素 (P 均<0.05)。结论　 成人急性淋巴细胞白血病患者化疗期间院内感染主要感染病原菌为革兰阴性菌，对碳青霉烯类抗菌药物敏感。成 人急性淋巴细胞白血病患者化疗期间发生院内感染的危险因素主要有白细胞数低、白蛋白水平低及疾病未获得完 全缓解。 [ABSTRACT FROM AUTHOR]

To predict the molecular structure and biological function of human insulin-like growth factor binding protein-3 (IGFBP-3). Methods IGFBP-3 mRNA and amino acid sequences were obtained from the American Bioinformatics Center. The tool ORF Finder online was used to analysis open reading frames， and ProtParam was used to predict physicochemical properties of IGFBP-3. Predict-Protein and SOPMA tools were used to predict the secondary structure of IGFBP-3, SWISS-MODEL was used to predict tertiary structure of IGFBP-3, SignalP4. 1 Server and NLStradamus tools were used to predict signaling peptide and nuclear localization signals of IGFBP-3，TMHMM software package was used to analyze the transmembrane region of IGFBP-3，BLAST tool was used to predict IGFBP-3 protein domains, String software was used to predict protein-protein interactions， and Gene Ontology Consortium was used to predict the biological function of IGFBP-3. Results IGFBP-3 was an unstable hydrophilic secretion protein，whose secondary structure was mainly the loop structure and the helix structure， with no transmembrane area， contained five conserved domains， and played biological effects in the nucleus. GO analysis showed that IGFBP-3 was involved in physiological activities such as apoptosis, negative regulation of cell proliferation, protein phosphorylation, signal transduction and insulin-like growth factor receptor signaling pathway. Conclusion Human IGFBP-3 is a negative regulator of tumorigenesis，mediates MMP2 and its downstream signaling pathway， and thus regulate the occurrence and development of tumor. [ABSTRACT FROM AUTHOR]

机体免疫系统可通过肿瘤免疫循环有效防止体内肿瘤的发生(清除期);但如果肿瘤细胞相关抗原突变,以致不能被完全清除而进一步发展,进入平衡期;免疫系统这种持续的选择压力促使肿瘤细胞发展出高免疫抗性的克隆,以对抗免疫细胞的清除并进而发展为肿瘤。临床前研究发现肿瘤的放射敏感性与宿主的免疫状况有关。而放射治疗可通过诱导肿瘤细胞产生免疫原性细胞死亡,招募T细胞至照射肿瘤区,增加肿瘤细胞对T细胞杀伤的脆性,提高肿瘤免疫治疗的疗效。因此优化放射和免疫治疗的协同作用成为目前研究的热点。而放射与免疫治疗联合的关键因素包括放射治疗的分割方式及分割剂量、照射靶病灶的选择、照射范围及治疗时序安排。 [ABSTRACT FROM AUTHOR]

Objective To observe the effect of Taohong Siwu decoction on the microstructure of femoral head in rabbits with steroid-induced osteonecrosis of the femoral head ( SIONFH) and to explore its possible mechanism. Methods Fifty healthy New Zealand white rabbits were randomly divided into the model group ( n = 2 0 ) ， observation group ( n = 2 0 )，and normal control group ( n = 10). The SIONFH models in the model group and the observation group were established. After establishment，rabbits in the observation group were given the mixture of Taohong Siwu decoction by gavage. The rabbits in the model group and normal control group were given equal volume of normal saline，once a day，for 12 weeks. At the end of 12 weeks of gavage，high-resolution magnetic resonance ( HRMR) was performed in each group to calculate coronal necrotic area ( R O E)，normal area ( N R )，and ROE/NR. The rabbits were sacrificed to obtain the bilateral femoral heads. The left femur was scanned by Micro-CT system. The parameters such as，tissue volume ( T V )，bone volume ( B V )，bone surface area ( BS) connection density ( Conn. D. ) ，structural model index ( SM I)，number of trabecular bone ( Tb. N )，trabecular bone thickness ( Tb. Th) % trabecular bone separation ( Tb. Sp) were recorded，and BV/TV and BS/BV were calculated. The protein expression of runt-related transcription factor 2 ( RUNX2)，osteopontin ( OPN) ， peroxisome proliferator-activated receptor ( ( P P A R ()，osteoprotegerin ( OPG) ， osteopontin ( ABCB1 ) ， NF- k B receptor activating factor ( RANK) ， vascular endothelial growth factor ( VEGF) ， and nuclear factor kB receptor activator ligand ( RANKL) in the right femur tissues were measured by Western blotting. Results The ROE and ROE/NR in the model group were higher than those in the observation group and normal control group，and NR was lower than that in the observation group and normal control group ( P <0. 05 or P <0. 01). The levels of BS/BV and Tb. Sp in the model group were significantly higher than those in the observation group and the normal control group ( P < 0. 05 or P < 0. 01 ) . The levels of Conn. D. and Tb. N of the model group were lower than those in the observation group and the normal control group ( P < 0. 05 or P <0. 01 ) . The level of BV/TV in the observation group and model group was lower than that in the normal control group，and the level of Tb. Th in the model group was lower than that of the normal control group ( both P < 0. 05 ). The protein expression levels of ABCB1，OPG，and VEGF in the model group were lower than those in the observation group and the normal control group ； the protein expression levels of RANK and RANKL in the model group were higher than those in the observation group and the normal control group ( all P < 0. 05 ). The relative expression of RUNX2 protein in the femoral head tissues of the model group and the observation group was higher than that of the normal control group，and the observation group was more obvious ( P< 0 .0 5 ). There was no significant difference in the relative protein expression of OPN and PPAR( between the three groups ( both P > 0 .0 5 ). Conclusion Taohong Siwu decoction can improve the number and density of trabecular bone in femoral head of SIONFH rabbits，improve its microstructure，and promote the repair of necrotic tissues by promoting osteogenesis，increasing the expression of vascular growth factor，inhibiting osteoporosis，and decreasing the expression of lipid factor. [ABSTRACT FROM AUTHOR]

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目前,放射治疗尤其是立体定向放射治疗已成为头颈部肿瘤患者的主要治疗手段之一,放射性脑损伤是放射治疗后的中枢神经系统严重并发症之一。急性放射性脑损伤经早期发现并积极治疗多可恢复,晚期放射性脑损伤则为不可逆性病变。常规的MRI、CT等影像学检查方法仅能发现晚期放射性脑损伤,无法早期发现急性放射性脑损伤时的组织代谢异常而延误诊断。功能磁共振成像技术包括共振波谱、灌注加权成像、扩散加权成像、扩散张量成像、扩散峰度成像,能发现非常微小的信号强度变化,可为急性放射性脑损伤的早期诊断提供帮助。 [ABSTRACT FROM AUTHOR]

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目的探讨尖锐湿疣皮损组织人β防御素2(HBD-2)、HBD-3、B细胞淋巴瘤2(Bcl-2)表达变化及意义。方法选择尖锐湿疣患者165例(观察组),均给予皮损部位液氮冷冻治疗,将全部疣体皮损清除,并外用康复新液1个月;分别于治疗前及治疗结束时收集皮损组织标本,女性主要选择阴道及大小阴唇等部位疣体组织,男性主要选择肛周及阴茎等部位疣体组织。同期选择皮肤健康志愿者165例(对照组),其中男性标本为包皮环切术后的正常包皮,女性标本为性器官美容整形患者的健康外阴。采用免疫组织化学法检测各组织HBD-2、HBD-3、Bcl-2表达,采用Pearson相关分析法分析尖锐湿疣患者皮损组织HBD-2、HBD-3、Bcl-2表达的关系。结果观察组治疗前皮损组织HBD-2、HBD-3表达的平均光密度(MOD)值及Bcl-2阳性率均高于对照组(P均<0.01);观察组治疗后皮损组织HBD-2、HBD-3表达的MOD值及Bcl-2阳性率均低于治疗前(P均<0.01)。尖锐湿疣患者皮损组织HBD-2、HBD-3表达与Bcl-2表达均呈正相关(r分别为0.709、0.680,P均<0.05),HBD-2与HBD-3表达呈正相关(r=0.671,P<0.05)。结论尖锐湿疣皮损组织HBD-2、HBD-3、Bcl-2表达均上调,三者表达变化参与尖锐湿疣的发生并可反映疾病转归。 [ABSTRACT FROM AUTHOR]

目的 探讨血清胃蛋白酶原、胃泌素水平对胃癌的诊断效能。方法 ４８２ 例胃部疾病患者，均行胃镜检 查，根据病理组织结果分为胃癌组５８ 例、胃溃疡组１２３ 例、慢性萎缩性胃炎组７６ 例、慢性非萎缩性胃炎组２２５ 例，， 抽取患者空腹静脉血，采用时间分辨荧光免疫分析法检测各组血清胃蛋白酶原Ⅰ（ＰＧⅠ）、胃蛋白酶原Ⅱ（ＰＧⅡ）、 胃泌素１７（Ｇ１７），计算ＰＧＲ（ＰＧⅠ／ ＰＧⅡ）。绘制受试者工作特征曲线分析ＰＧⅠ、ＰＧⅡ、Ｇ１７ 水平及ＰＧＲ 对胃癌 的诊断效能。结果 胃癌组血清ＰＧⅠ水平明显高于其余三组（Ｐ 均＜ ０． ０５）。各组血清ＰＧⅡ水平间差异无统计 学意义。胃癌组ＰＧＲ 明显低于其余三组（Ｐ 均＜０． ０５）。胃癌组血清Ｇ１７ 水平明显低于慢性萎缩性胃炎组、慢性 非萎缩性胃炎组（Ｐ 均＜０． ０５）。血清ＰＧⅠ水平诊断胃癌ＲＯＣ 的曲线下面积为０． ８８７，最佳临界值为７４． ８ ｎｇ／ ｍＬ， 灵敏度８５． ９％ ，特异度为７６． ３％ ；ＰＧＲ 诊断胃癌ＲＯＣ 的曲线下面积为０． ７８４，最佳诊断临界值为３． ８，灵敏度 ８８． ６％ ，特异度６３． ４％ ；血清Ｇ１７ 水平诊断胃癌ＲＯＣ 的曲线下面积为０． ３２１，无诊断价值。结论 胃癌患者血清 ＰＧⅠ水平升高、Ｇ１７ 水平降低。ＰＧⅠ、ＰＧＲ 诊断胃癌的灵敏度、特异度均较高，检测血清ＰＧⅠ、ＰＧＲ 有助于胃癌的 诊断 [ABSTRACT FROM AUTHOR]

目的观察食管鳞状细胞癌（ESCC)组织中三磷酸腺苷结合盒转运蛋白G2(ABCG2)及P16表达变化， 并探讨其临床意义。方法选取136例份ESCC组织及37例份正常食管黏膜组织（距癌组织>5 cm)，用免疫组 化SP染色法检测两种组织中ABCG2及P16蛋白表达，用qRT-PCR法检测两种组织中ABCG2与P16 mRNA表达。 分析ABCG2及P16蛋白阳性表达与患者临床病理参数的关系，用Spearman等级相关分析ABCG2、P16表达的相关 性结果与正常食管黏膜组织比较，ESCC组织中ABCG2蛋白阳性表达率高(P <0.05)、P16蛋白阳性表达率低 (P<0.05)。与正常食管黏膜组织比较，ESCC组织中ABCG2 mRNA相对表达量高（P<0• 05)、pl6 mRNA相对表 达量低(P<0.05)。ABCG2及P16蛋白阳性表达与食管鳞癌肿瘤浸润深度、TNM分期及淋巴结转移有关(P均< 0. 05)，与患者性别、年龄及肿瘤组织学分级无关(P均>0. 05)。ESCC组织中ABCG2与P16蛋白表达呈负相关(r =-0.438，P<0.05)。结论 ABCG2在ESCC组织中呈高表达，P16呈低表达;二者可能协同作用参与ESCC的发 生发展。 [ABSTRACT FROM AUTHOR]

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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的探讨沙棘水提物对短波紫外线(UVC)辐射人角质形成细胞(HaCaT细胞)损伤的保护作用及其机制。方法体外培养HaCaT细胞株,将其随机分成对照组、UVC模型组、沙棘水提物2 mg/m L组、沙棘水提物20mg/m L组。对照组不加药,不进行UVC照射;UVC模型组去盖置于UVC消毒灯管(30 W,辐射距离70 cm)下进行照射,辐射剂量为20 J/m2,照射30 min;沙棘水提物组分别加入2、20 mg/m L沙棘水提物5 min后,进行UVC照射,辐射剂量及时间同上。辐射后用PBS洗2遍,换完全培养基继续培养24 h。观察各组细胞的形态及数量变化,酶标法测定细胞中的超氧化物歧化酶(SOD)活力、过氧化氢酶(CAT)活力及细胞培养上清液中谷胱甘肽过氧化物酶(GSH-PX)活力,细胞中丙二醛(MDA)含量。结果对照组细胞形态良好,细胞呈上皮细胞样贴壁生长,细胞呈圆梭形,彼此之间伸出伪足连接,细胞核清晰可见。UVC模型组可见大量细胞碎片,大量细胞凋亡,细胞形态模糊不清,活细胞数明显减少。各沙棘水提物组细胞损伤程度减轻,随着沙棘水提物浓度的升高细胞形态逐渐趋于正常,且凋亡细胞数量逐渐减少,存活细胞数目逐渐增多。与对照组比较,其余各组活细胞数减少(P均<0.05);与UVC模型组比较,沙棘水提物2 mg/m L组、沙棘水提物20 mg/m L组活细胞数增加(P均<0.05)。 与对照组比较,除沙棘水提物20 mg/m L组细胞SOD活力差异无统计学意义外,其余组细胞中SOD、CAT活力及细胞培养上清液中GSH-PX活力均降低,MDA含量升高。与UVC模型组比较,沙棘水提物2 mg/m L、20 mg/m L组细胞中SOD、CAT活力,细胞培养上清液中GSH-PX活力升高,细胞中MDA含量降低(P均<0.05)。结论沙棘水提物对UVC照射HaCaT细胞造成的损伤具有保护作用,其机制可能与其抗氧化作用及增强细胞生存活力有关。 [ABSTRACT FROM AUTHOR]

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目的：探讨冠状动脉慢性完全闭塞病变（CTO）患者介入治疗后心功能改善的影响因素。方法选择成功介入治疗冠状动脉 CTO 患者48例，根据介入治疗后9～12个月心功能变化分为改善组29例和未改善组19例，比较两组年龄，心绞痛病程，吸烟、高血压、糖尿病、血脂异常病史，血糖、血脂、血清 N 端脑钠肽前体（NT-proB-NP）等指标，以及冠脉病变、侧枝循环特点，分析影响介入治疗后心功能改善的因素。结果改善组年龄（48．6±6．1）岁，心绞痛病程（110．7±29．6）周，术前血清 NT-proBNP 水平为（230．20±58．30）pg／mL；未改善组年龄（61．4±10．3）岁，心绞痛病程（110．7±29．6）周，术前血清 NT-proBNP 水平为（403．90±81．10）pg／mL；两组年龄、心绞痛病程、术前血清 NT-proBNP 水平比较差异有统计学意义（P ＜0．01或＜0．05）。心功能改善组侧枝循环评分高于未改善组（P ＜0．05）。Logistic 回归分析显示，年龄较轻（OR ＝0．913，95％CI 0．769～0．985，P ＝0．031，）、心绞痛病程较短（OR ＝0．938，95％CI 0．893～0．984，P ＝0．010）是心功能改善的独立正向预测因素。结论年龄及心绞痛病程对冠状动脉 CTO 患者术后心功能改善有显著影响。 [ABSTRACT FROM AUTHOR]

目的　比较连续股神经阻滞镇痛(CFNB)联合塞来昔布与静脉自控镇痛(PCIA)联合塞来昔布镇痛模式在老年髋部骨折术后的镇痛效果。方法择期行腰硬联合麻醉下髋部手术的老年患者60例,随机分为C组、P组各30例,分别采用超声引导CFNB+塞来昔布、PCIA+塞来昔布镇痛。记录并比较两组术后4、8、12、24、48 h运动视觉模拟疼痛评分(VAS),手术前后血清皮质醇、痛阈、耐痛阈,加用镇痛药物比例,记录穿刺部位出血、感染及恶心呕吐等术后镇痛并发症发生情况。结果　与C组相比,P组术后4、8 h的VAS以及术后痛阈、耐痛阈较高(P均<0.01),术后血清皮质醇较低(P<0.01),追加追加镇痛药物比例较少(P<0.05)。两组不良反应发生率差异无统计学意义。结论　与PCIA联合塞来昔布相比,CFNB联合塞来昔布镇痛用于老年人髋部骨折术后具有更好的镇痛效果,且能有效减少应激反应,提高患者痛阈及耐痛阈,减少术后额外镇痛药物用量。 [ABSTRACT FROM AUTHOR]

目的　探讨非小细胞肺癌（ＮＳＣＬＣ）组织３′-脱氧-３′-１８Ｆ-氟代胸苷（１８Ｆ-ＦＬＴ）ＰＥＴ显像所示１８Ｆ-ＦＬＴ高摄取区与肿瘤细胞高增殖区的一致性。方法　选择１２例初治、接受根治性手术切除治疗的ＮＳＣＬＣ患者。术前３ｄ行１８Ｆ-ＦＬＴ ＰＥＴ ＣＴ 检查，以最大标准摄取值（ＳＵＶｍａｘ）的８０％为阈值勾画ＦＬＴ的高摄取区。术后取得完整的肿块并按在体方向还原，４ｍｍ层厚制作肺癌病理大切片并行ＨＥ染色及Ｋｉ-６７染色，Ｋｉ-６７指数＞２０％的区域为高表达区，ＰＥＴ图像与病理图像进行配准后比较高摄取区与高表达区位置是否相同。结果　１２例患者成功制作病理切片并顺利阅片。５例１８Ｆ-ＦＬＴ高摄取区与Ｋｉ-６７高表达区一致。结论　ＮＳＣＬＣ组织１８Ｆ-ＦＬＴ高摄取区与Ｋｉ-６７高表达所代表的肿瘤细胞高增殖区并非完全一致。 [ABSTRACT FROM AUTHOR]

目的：观察短节段椎弓根钉内固定术联合经椎弓根植骨治疗胸腰椎骨折的疗效。方法胸腰椎骨折患者103例，对照组47例予以短节段椎弓根钉内固定术治疗，观察组56例在对照组术式基础上采用经椎弓根椎体内植骨。记录两组手术时间、术中出血量、术后引流量、住院时间和脊髓功能优良率。末次随访时进行视觉模拟评分（VAS）评价腰背部疼痛情况。比较两组术前及末次随访时椎管侵占率、Cobb角、伤椎前缘高度比值。结果术后随访24～48个月，观察组脊髓功能优良率（67．86％）高于对照组（42．22％）， P＜0．05。两组手术时间、术中出血量、术后引流量、住院时间及术后VAS差异无统计学意义（P均＞0．05）。两组术后椎管侵占率和Cobb角均低于术前，伤椎前缘高度比值高于术前（P均＜0．01）；观察组术后椎管侵占率和Cobb角低于对照组，伤椎前缘高度比值高于对照组（P均＜0．01）。结论短节段椎弓根钉内固定术联合经椎弓根椎体内植骨治疗胸腰椎骨折疗效较好。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的：观察蠲痹汤治疗冠状动脉支架植入术后胸痛痰瘀互阻证患者的疗效。方法将87例冠状动脉支架植入术后胸痛痰瘀互阻证患者随机分为观察组44例和对照组43例，分别口服蠲痹汤、消心痛治疗2周，观察临床疗效及不良反应。结果观察组显效12例、有效18例、无效14例、总有效率68．18％，对照组分别为10、15、18例及58．13％；两组总有效率比较，P＞0．05。观察组出现腹胀、嗳气1例（2．27％），对照组出现头痛、低血压5例（11．62％），P＜0．01。结论蠲痹汤治疗冠状动脉支架植入术后胸痛痰瘀互阻证患者疗效较好，不良反应少。 [ABSTRACT FROM AUTHOR]

目的：观察拉帕替尼及顺铂对人食管癌细胞株Eca109的增殖抑制作用，探讨两者是否存在协同效应。方法将对数生长期的Eca-109细胞随机分为4组，A组不处理、B组仅用拉帕替尼、C组仅用顺铂、D组用拉帕替尼联合顺铂处理24 h，拉帕替尼浓度分别为0．05、0．5、1、2．5、5、12．5、25μmol／L，顺铂浓度分别为0．5、1、2、4、8、16、32μg／L。采用MTT法检测细胞抑制率，采用协同作用q值判断拉帕替尼与顺铂联用的效果（q在0．85～1．15为作用相加）。结果与A组比较，B、C、D组细胞抑制率增高，且随着浓度增加逐渐增高，P均＜0．05。拉帕替尼和顺铂浓度组合5μmol／L＋8μg／L、12．5μmol／L＋16μg／L、25μmol／L＋32μg／L时，q分别为0．85、0．86、0．85。结论拉帕替尼和顺铂单药及联合对Eca109均有显著抑制作用，其作用存在浓度依赖性；两者联合存在相加作用。 [ABSTRACT FROM AUTHOR]

目的探讨胰岛素抵抗(IR)对多囊卵巢综合征(PCOS)患者血清性激素水平的影响及机制。方法研究对象为同期收治的64例POCS患者(POCS组),其中伴IR(IR指数>1.95)48例、不伴IR 18例;同期40例正常育龄期健康体检者为正常组。采用免疫发光法检测两组血清性激素[雌二醇(E2)、睾酮(T)、脱氢表雄酮(DHEA)]水平;分析POCS组性激素水平与IR指数的相关性。结果 PCOS组血清E2、T、DHEA水平均高于对照组(P均<0.05);POCS伴IR者血清T、DHEA水平高于不伴IR者(P均<0.05);PCOS患者血清T、DHEA水平与IR间呈显著正相关(r=0.574、0.428,P均<0.05),而血清E2水平与IR无相关性。结论血清性激素水平可作为新的检测指标提高PCOS伴IR的诊断水平。 [ABSTRACT FROM AUTHOR]