头颈部鳞癌放射敏感性研究趋势和热点的可视化分析.

Objective To analyze ihe trend and hot spots of worldwide research on radiosensitivity of head and neck squamous cell carcinoma (HNSCC), and to provide information support for researchers to carry out relevant scientific research further. Methods Firstly, the articles on radiosensitivity of head and neck carcinoma were retrieved in PubMed. then the relevant articles on radiosensitivity of IINSCC were screened out according to inclusion and exclusion criteria. By the quantitative and co-word biclustering method, the annual amount of articles, core journals and hot topics were analyzed in this field. Results A total of 1 117 related papers were retrieved. Since 1980.the amount of articles on IINSCC radiosensitivity showed an exponential increasing trend. There were 11 core journals in this field, of which, the international journal of radiation oncology, biology, physics published the largest number of relevant publications. The hot research topics in this field mainly include; (1) radiosensitivity of nasopharyngeal carcinoma, (2) radiosensitization associated with epidermal growth factor receptor (EGFR), (3) radiosensitizers of the IINSCC, (4) prediction of HNSCC radiosensitivity by tumor biomarkers, (5) metabolism of IINSCC radiosensitivity, (6)radiosensitivity of esophageal squamous carcinoma, and (7) genetic mechanism underlying the IINSCC radiosensitivity. Conclusions In the recent years, the research on IINSCC radiosensitivity has entered a stage of accelerated development. The HNSCC radiosensitivity is mainly explored from the perspective of genetics and metabolism. The major tumors involved are nasopharyngeal carcinoma and esophageal squamous cell carcinoma. The mechanism and application of radiosensitizers is also an important hot spot. [ABSTRACT FROM AUTHOR]