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3 results on '"Sámuel, Komoly"'

1. Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats

Author

Szilvia Anett Nagy, Ivan Ivic, Péter Tóth, Sámuel Komoly, Tamás Kiss, Máté Pénzes, András Málnási-Csizmadia, Tamás Dóczi, Gábor Perlaki, and Gergely Orsi

Subjects
Medicine, Science
Abstract

Abstract Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (ADC) MRI data obtained during MCAO and shortly after reperfusion for their potentials in acute-phase outcome prediction. Fifty-nine male rats underwent a 45-min MCAO. Outcome was defined in three ways: 21-day survival; 24 h midline-shift and neurological scores. Animals were divided into two groups: rats surviving 21 days after MCAO (survival group, n = 46) and rats dying prematurely (non-survival/NS group, n = 13). At reperfusion, NS group showed considerably larger lesion volume and lower mean ADC of the initial lesion site (p

Published
2023
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2. Fast 3 T nigral hyperintensity magnetic resonance imaging in Parkinson’s disease

Author

Sámuel Komoly, Gergely Orsi, József Janszky, Gabriella Hernadi, Gábor Perlaki, Norbert Kovács, Szilvia Anett Nagy, and Dávid Pintér

Subjects
Adult, Male, Parkinson's disease, Science, Inversion recovery, Fluid-attenuated inversion recovery, Article, 030218 nuclear medicine & medical imaging, Motion, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Stage (cooking), Movement disorders, Aged, Multidisciplinary, medicine.diagnostic_test, Echo-Planar Imaging, business.industry, Parkinson Disease, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Hyperintensity, nervous system diseases, Substantia Nigra, nervous system, Female, business, Nuclear medicine, Biomarkers, 030217 neurology & neurosurgery, Multi echo, Gradient echo
Abstract

The absence of nigral hyperintensity is a promising MR marker for Parkinson’s disease (PD), but its small size imposes limitations on its routine use. Our aim was to compare Multi Echo Data Image Combination (MEDIC), segmented echo-planar imaging (EPISEG) and fluid-attenuated inversion recovery (FLAIR) sequences, as well as both magnitude (MAG) and susceptibility-weighted imaging (SWI) reconstructions of single-echo gradient echo for nigral hyperintensity imaging. Twenty-five healthy and twenty PD subjects were included. Sensitivity to motion artefacts, confidence of the radiologist in interpretation, rate of nondiagnostic scans and diagnostic accuracy were assessed. EPISEG was less motion-sensitive than MEDIC, MAG, and SWI, while FLAIR was less motion-sensitive than MAG and SWI. The reviewers were more confident when using EPISEG compared to any other techniques and MEDIC was superior to FLAIR. The proportions of nondiagnostic scans were lower for EPISEG than for other sequences. The best diagnostic performance was achieved for EPISEG (sensitivity = 65%, specificity = 96%). Using EPISEG, the absence of nigral hyperintensity in PD was associated with higher Hoehn-Yahr stage and MDS-UPDRS II + III. Nigral hyperintensity may be intact at the very early stages of PD. The promising properties of EPISEG may help the transfer of nigral hyperintensity imaging into daily clinical practice.

Published
2021
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3. Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats.

Author

Nagy, Szilvia Anett, Ivic, Ivan, Tóth, Péter, Komoly, Sámuel, Kiss, Tamás, Pénzes, Máté, Málnási-Csizmadia, András, Dóczi, Tamás, Perlaki, Gábor, and Orsi, Gergely

Subjects
REPERFUSION, STROKE, DIFFUSION magnetic resonance imaging, RATS, ARTERIAL occlusions, CEREBRAL arteries
Abstract

Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (ADC) MRI data obtained during MCAO and shortly after reperfusion for their potentials in acute-phase outcome prediction. Fifty-nine male rats underwent a 45-min MCAO. Outcome was defined in three ways: 21-day survival; 24 h midline-shift and neurological scores. Animals were divided into two groups: rats surviving 21 days after MCAO (survival group, n = 46) and rats dying prematurely (non-survival/NS group, n = 13). At reperfusion, NS group showed considerably larger lesion volume and lower mean ADC of the initial lesion site (p < 0.0001), while during occlusion there were no significant group differences. At reperfusion, each survival animal showed decreased lesion volume and increased mean ADC of the initial lesion site compared to those during occlusion (p < 10–6), while NS group showed a mixed pattern. At reperfusion, lesion volume and mean ADC of the initial lesion site were significantly associated with 24 h midline-shift and neurological scores. Diffusion MRI performed soon after reperfusion has a great impact in early-phase outcome prediction, and it works better than the measurement during occlusion. [ABSTRACT FROM AUTHOR]

Published
2023
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