26 results on '"Guo, Xu"'
Search Results
2. Serum folate associated with nonalcoholic fatty liver disease and advanced hepatic fibrosis
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Chen, Hao-Kai, Luo, Jing, Li, Xiu-Juan, Liao, Wan-Zhe, Hu, Yu-Qi, and Guo, Xu-Guang
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- 2023
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3. The effectiveness of the puncture channel plugging for reduction of complications after CT-guided percutaneous transthoracic needle biopsy
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Wang, Dong-xu, Wang, Yu-guang, Ding, Guo-xu, Li, Bo, Liu, Rui-nan, Ai, Zhong-wei, and Wang, Yang
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- 2023
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4. Comparison of CT findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients
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Wang, Dong-xu, Zhang, Qing, Wen, Qiu-ting, Ding, Guo-xu, Wang, Yu-guang, Du, Feng-xia, Zhang, Tian-yu, Zheng, Xiao-yang, Cong, Hou-yi, Du, You-li, Sang, Jun-zhi, Wang, Ming-da, and Zhang, Shan-xin
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- 2022
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5. Study on synergistic system of energy-absorbing yielding anti-impact supporting structure and surrounding rock
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Song, Yimin, Ren, He, Xu, Hailiang, Guo, Xu, Chen, Zheng, and An, Dong
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- 2022
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6. Genome-wide analysis of autophagy-related genes in Medicago truncatula highlights their roles in seed development and response to drought stress
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Yang, Mingkang, Wang, Liping, Chen, Chumin, Guo, Xu, Lin, Chuanglie, Huang, Wei, and Chen, Liang
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- 2021
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7. The mechanical principles behind the golden ratio distribution of veins in plant leaves
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Sun, Zhi, Cui, Tianchen, Zhu, Yichao, Zhang, Weisheng, Shi, Shanshan, Tang, Shan, Du, Zongliang, Liu, Chang, Cui, Ronghua, Chen, Hongjie, and Guo, Xu
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- 2018
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8. Comparison of CT findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients
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Dong-Xu, Wang, Qing, Zhang, Qiu-Ting, Wen, Guo-Xu, Ding, Yu-Guang, Wang, Feng-Xia, Du, Tian-Yu, Zhang, Xiao-Yang, Zheng, Hou-Yi, Cong, You-Li, Du, Jun-Zhi, Sang, Ming-da, Wang, and Shan-Xin, Zhang
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Immunocompromised Host ,Multidisciplinary ,Lung Diseases, Fungal ,Humans ,Cryptococcosis ,Tomography, X-Ray Computed ,Retrospective Studies - Abstract
Pulmonary cryptococcosis (PC) is a common fungal infectious disease, and infection can occur in patients with any immune function. To better understand PC, we compared the CT findings and histopathological results in immunocompetent and immunocompromised patients. The clinical data of 68 patients with PC were collected retrospectively and divided into the immunocompetent group and immunocompromised group. The clinical characteristics, CT manifestations and histopathological characteristics of the two groups of patients were compared. Forty-two patients (61.8%) were immunocompetent, and 26 patients (38.2%) were immunocompromised. Compared with immunocompromised patients, 57.14% (24/42) of immunocompetent patients were asymptomatic (p = 0.002). Compared with immunocompetent patients, cough (14/26, 53.9%) and fever (13/26, 50.0%) were the main symptoms in immunocompromised patients (p = 0.044, p = 0.007). Nodular lesions (97.6%, 41/42) were the most common CT type in immunocompetent patients, and the CT characteristic was a single lesion (25/42, 59.5%); the main histopathological type was nodular fibrogranuloma (30/42, 71.4%), and the main histopathological characteristic was inflammatory granuloma (31/42, 73.81%) formed by macrophage phagocytosis of Cryptococcus. Consolidation (15/26, 57.7%) was more common in the CT type of immunocompromised patients. Multiple lesions (24/26, 92.31%), air bronchial signs (19/26, 73.081%) and cavities (9/26, 34.62%) were the main CT characteristics. The mucinous colloid type (19/26, 73.1%) was its main histopathological type, which was mainly characterized by a small amount of surrounding inflammatory cell infiltration (17/26, 65.4%). There were significant differences in the classification and characteristics of CT and pathology between the two groups (p
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- 2022
9. Polyhydroxy cucurbitane triterpenes from Hemsleya penxianensis tubers
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Zhu Nailiang, Xudong Xu, Jun-Shan Yang, Zhong-Hao Sun, Zhaocui Sun, Xiaowei Huo, Xiaolei Zhou, Meigeng Hu, and Guo-Xu Ma
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0301 basic medicine ,Stereochemistry ,Proton Magnetic Resonance Spectroscopy ,Positive control ,lcsh:Medicine ,Medicinal chemistry ,Moths ,Cucurbitane ,Article ,Terpene ,Inhibitory Concentration 50 ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Western blot ,Ic50 values ,medicine ,Animals ,Glycosides ,Carbon-13 Magnetic Resonance Spectroscopy ,lcsh:Science ,Multidisciplinary ,Dihydrocucurbitacin F ,medicine.diagnostic_test ,biology ,Structure elucidation ,lcsh:R ,Plutella ,Feeding Behavior ,biology.organism_classification ,Triterpenes ,Biosynthetic Pathways ,Cucurbitaceae ,Plant Tubers ,IκBα ,030104 developmental biology ,chemistry ,Environmental chemistry ,lcsh:Q ,Secondary metabolism ,Solution-state NMR ,030217 neurology & neurosurgery - Abstract
Ten new cucurbitane triterpenoids, hemsleyacins A–J (1–10), together with three known cucurbitane triterpenoids, dihydrocucurbitacin F (11), scandenogenin D (12), and jinfushanencin F (13), were separated from ethanolic tuber extracts of Hemsleya penxianensis. The absolute configurations of the new compounds were established based on NMR, HRESIMS, and CD spectra. Compounds 7 and 10–12 were evaluated in terms of their antifeedant activity against Plutella xylostella larvae. The result showed that compound 10 exhibited potent antifeedant activity against P. xylostella larvae after 48 h of treatment. Furthermore, the MTT test showed that compound 11 exhibited potent inhibition toward the UMUC-3 and T24 cell lines with IC50 values of 29.12 and 35.62 μM, respectively, compared to the positive control cisplatin IC50 values of 8.27 and 13.72 μM. Western blot analysis revealed that compound 11 treatments substantially inhibited the phosphorylation of IκBα.
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- 2019
10. Chemical composition, antibacterial activity and action mechanism of different extracts from hawthorn (Crataegus pinnatifida Bge.)
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Lifang Zhang, Jian-Guo Xu, and Liang-Liang Zhang
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Ethyl acetate ,lcsh:Medicine ,Microbial Sensitivity Tests ,Gram-Positive Bacteria ,01 natural sciences ,Biochemistry ,Microbiology ,Catechin ,Article ,Membrane Potentials ,chemistry.chemical_compound ,0404 agricultural biotechnology ,Chlorogenic acid ,Phenols ,Cell Wall ,Gram-Negative Bacteria ,Petroleum ether ,Food science ,lcsh:Science ,Procyanidin B2 ,Chromatography, High Pressure Liquid ,Flavonoids ,Crataegus ,Multidisciplinary ,biology ,Chemistry ,Plant Extracts ,010401 analytical chemistry ,lcsh:R ,Biological techniques ,04 agricultural and veterinary sciences ,Crataegus pinnatifida ,biology.organism_classification ,040401 food science ,0104 chemical sciences ,Anti-Bacterial Agents ,Polyphenol ,lcsh:Q ,Chlorogenic Acid ,Antibacterial activity ,Quercetin ,Reactive Oxygen Species ,Biotechnology - Abstract
Present study was designed to compared the total flavonoids and polyphenols contents and antibacterial activity of hawthorn extracts with different polarities as well as the underlying antibacterial mechanisms. The results showed that among all hawthorn extracts, methanol and ethanol extracts (ME and EE) exhibited high levels of total flavonoids and polyphenols contents, followed by acetone, ethyl acetate, trichloromethane and petroleum ether extracts. ME exhibited the strongest antibacterial activity against tested bacteria, especially Staphylococcus aureus with a 1.25 μg/mL of the minimum inhibitory concentration (MIC) and minimum bactericide concentration (MBC). Further analysis revealed that the main phenolic compounds from ME were epicatechin (281.6 mg/100 g DW), procyanidin B2 (243.5 mg/100 g DW), chlorogenic acid (84.2 mg/100 g DW) and quercetin (78.4 mg/100 g DW). The action mechanism of ME against S. aureus could be ascribed to ME damaging cell wall and cell membrane integrity, inhibiting intracellular enzyme activity, increasing reactive oxygen species (ROS), also changing expression of associated genes and then inducing apoptosis of S. aureus. In addition, the antimicrobial activity of ME against S. aureus has also been demonstrated to be efficient in the food matrix (whole milk).
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- 2019
11. Involvement of GATA1 and Sp3 in the activation of the murine STING gene promoter in NIH3T3 cells
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Hua-Guo Xu, Yan-Yan Xu, Rui Jin, and Guo-Ping Zhou
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Transcriptional Activation ,0301 basic medicine ,Science ,Response element ,Biology ,Article ,Mice ,03 medical and health sciences ,Transcription (biology) ,Animals ,GATA1 Transcription Factor ,Promoter Regions, Genetic ,Gene ,Gene knockdown ,Multidisciplinary ,General transcription factor ,Membrane Proteins ,Promoter ,GATA1 ,3T3 Cells ,Molecular biology ,Sp3 Transcription Factor ,030104 developmental biology ,Medicine ,Chromatin immunoprecipitation - Abstract
Stimulator of Interferon Gene (STING) is a key mediator of innate immune signaling. STING plays a pivotal role in the pathogenesis of many diseases including infectious diseases, auto-immune diseases and cancer. Many studies have been carried out recently in the field of STING-regulated pathway, however, rarely of transcriptional mechanisms. To characterize the murine STING (mSTING) promoter, we cloned a series of different nucleotide sequences of the 5′-flanking region of the mSTING gene. Transient transfection of promoter-reporter recombinant plasmids and luciferase assay illustrated the region (−77/+177) relative to the transcription start site (TSS) of the mSTING gene was sufficient for full promoter activity. This region contains GATA1, IK2, Sp1/Sp3 and STAT putative transcription factor binding sites. Mutation of GATA1 or Sp1/Sp3 sites led to obvious decrease of the mSTING promoter activity. Overexpression of GATA1 and Sp3 enhanced the mSTING promoter activity, whereas knockdown of GATA1 and Sp3 by a siRNA strategy significantly reduced the transcription activity. Chromatin immunoprecipitation assays demonstrated that GATA1 and Sp3 interact with the mSTING promoter in vivo. These results provided the first analysis of mSTING promoter and demonstrated that transcription factor GATA1 and Sp3 positively regulate the basal transcription of the mSTING gene.
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- 2017
12. Determining the geographical origin of common buckwheat from China by multivariate analysis based on mineral elements, amino acids and vitamins
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Jian-Guo Xu and Qiang Zhang
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China ,Multivariate analysis ,lcsh:Medicine ,Mineralogy ,Biology ,Inner mongolia ,01 natural sciences ,Article ,Classification rate ,0404 agricultural biotechnology ,Cluster Analysis ,Food science ,Amino Acids ,lcsh:Science ,chemistry.chemical_classification ,Minerals ,Principal Component Analysis ,Multidisciplinary ,Geography ,lcsh:R ,010401 analytical chemistry ,Discriminant Analysis ,Vitamins ,04 agricultural and veterinary sciences ,Linear discriminant analysis ,040401 food science ,0104 chemical sciences ,Amino acid ,chemistry ,Principal component analysis ,lcsh:Q ,Fagopyrum - Abstract
This study aimed to establish a method for distinguishing the geographical origin of common buckwheat from Inner Mongolia, Shanxi and Shaanxi Provinces in China. Three chemical families including mineral elements, vitamins and amino acids of 48 samples from different geographical origins were analyzed by principal component analysis (PCA), cluster analysis (CA) and linear discriminate analysis (LDA) for this purpose. LDA clearly discriminated the geographical origin of common buckwheat samples grown in three regions, and gave a high correct classification rate of 95.8% and satisfactory cross-validation rate of 91.7%. Some variables (Mn, VPP, Se, Gly, Cu, Asp, Fe, and Ala) significantly contributed to the ability to discriminate the geographical origin of the common buckwheat. These results demonstrated that the proposed method is a powerful tool for controlling the geographical origin of common buckwheat by governmental administration and protecting consumers from improper domestic labeling. However, the discriminant method still needs to be further validated using more reliable data.
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- 2017
13. Sets of serum exosomal microRNAs as candidate diagnostic biomarkers for Kawasaki disease
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Yu-Fen Xu, Gong Zhang, Ming-Guo Xu, Hong-Ling Jia, Wei-Jun Xu, Chao-Wu Liu, Jun Bai, Li Zhang, and Xuejuan Gao
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0301 basic medicine ,Oncology ,medicine.medical_specialty ,Heart disease ,Microarray ,Mucocutaneous Lymph Node Syndrome ,Exosomes ,Article ,03 medical and health sciences ,Internal medicine ,False positive paradox ,medicine ,Humans ,Multidisciplinary ,business.industry ,Gene Expression Profiling ,Reproducibility of Results ,Reference Standards ,medicine.disease ,Biobank ,Gene expression profiling ,MicroRNAs ,030104 developmental biology ,Real-time polymerase chain reaction ,Biomarker (medicine) ,Kawasaki disease ,business ,Biomarkers - Abstract
Although Kawasaki disease is the main cause of acquired heart disease in children, no diagnostic biomarkers are available. We aimed to identify candidate biomarkers for diagnosing Kawasaki disease using serum exosomal microRNAs (miRNAs). Using frozen serum samples from a biobank, high-throughput microarray technologies, two-stage real-time quantitative PCR, and a self-referencing strategy for data normalization, we narrowed down the list of biomarker candidates to a set of 4 miRNAs. We further validated the diagnostic capabilities of the identified miRNAs (namely, CT(miR-1246)-CT(miR-4436b-5p) and CT(miR-197-3p)-CT(miR-671-5p)) in 79 samples from two hospitals. We found that this 4-miRNA set could distinguish KD patients from other febrile patients as well as from healthy individuals in a single pass, with a minimal rate of false positives and negatives. We thus propose, for the first time, that serum exosomal miRNAs represent candidate diagnostic biomarkers for Kawasaki disease. Additionally, we describe an effective strategy of screening for biomarkers of complex diseases even when little mechanistic knowledge is available.
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- 2017
14. TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation
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Hao Xiong, Maojin Liang, Huaili Jiang, Xi Huang, Guo Xu, Yi Liu, Qiuhong Huang, Yu Bin Chen, Zhuohao Li, Yiqing Zheng, Ximing Chen, Zhigang Zhang, Suijun Chen, and Yu Si
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0301 basic medicine ,Adult ,Male ,Osteoclasts ,Matrix metalloproteinase ,Real-Time Polymerase Chain Reaction ,Bone and Bones ,Article ,Proinflammatory cytokine ,03 medical and health sciences ,Mice ,Young Adult ,0302 clinical medicine ,Downregulation and upregulation ,Osteoclast ,medicine ,otorhinolaryngologic diseases ,Animals ,Humans ,Secretion ,Receptors, Immunologic ,Aged ,Multidisciplinary ,Membrane Glycoproteins ,Chemistry ,Middle Aged ,Up-Regulation ,Mice, Inbred C57BL ,Toll-Like Receptor 4 ,TLR2 ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cancer research ,TLR4 ,Cytokines ,Female ,Signal transduction ,Inflammation Mediators ,Signal Transduction - Abstract
Triggering receptor expressed on myeloid cells (TREM) has been broadly studied in inflammatory disease. However, the expression and function of TREM-2 remain undiscovered in acquired cholesteatoma. The expression of TREM-2 was significantly higher in human acquired cholesteatoma than in normal skin from the external auditory canal, and its expression level was positively correlated with the severity of bone destruction. Furthermore, TREM-2 was mainly expressed on dendritic cells (DCs). In human acquired cholesteatoma, the expression of proinflammatory cytokines (IL-1β, TNF-α and IL-6) and matrix metalloproteinases (MMP-2, MMP-8 and MMP-9) were up-regulated, and their expression levels were positively correlated with TREM-2 expression. Osteoclasts were activated in human acquired cholesteatoma. In an animal model, TREM-2 was up-regulated in mice with experimentally acquired cholesteatoma. TREM-2 deficiency impaired the maturation of experimentally acquired cholesteatoma and protected against bone destruction induced by experimentally acquired cholesteatoma. Additional data showed that TREM-2 up-regulated IL-1β and IL-6 expression via TLR4 instead of the TLR2 signaling pathway and promoted MMP-2 and MMP-8 secretion and osteoclast activation in experimentally acquired cholesteatoma. Therefore, TREM-2 might enhance acquired cholesteatoma-induced bone destruction by amplifying the inflammatory response via TLR4 signaling pathways and promoting MMP secretion and osteoclast activation.
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- 2016
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15. A novel hepatovirus identified in wild woodchuck Marmota himalayana
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Zhi-ping Xie, Han-chun Gao, Lili Pang, Cui-yuan Zhang, Jie-mei Yu, Lili Li, Xiaoman Sun, Zhao-jun Duan, W. Ian Lipkin, Shan Lu, Jian-guo Xu, Yuanyun Ao, and Guang-Cheng Xie
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0301 basic medicine ,Most recent common ancestor ,Genotype ,Picornavirus ,viruses ,Genome, Viral ,Article ,Virus ,Evolution, Molecular ,Epitopes ,Open Reading Frames ,03 medical and health sciences ,Animals ,Hepatovirus ,Codon ,Antigens, Viral ,Phylogeny ,Tropism ,Genetics ,Base Composition ,Multidisciplinary ,biology ,Phylogenetic tree ,fungi ,virus diseases ,Bayes Theorem ,Genomics ,biochemical phenomena, metabolism, and nutrition ,Marmota himalayana ,biology.organism_classification ,Virology ,digestive system diseases ,030104 developmental biology ,Marmota ,Codon usage bias ,Nucleic Acid Conformation ,RNA, Viral - Abstract
Hepatitis A virus (HAV) is a hepatotropic picornavirus that causes acute liver disease worldwide. Here, we report on the identification of a novel hepatovirus tentatively named Marmota Himalayana hepatovirus (MHHAV) in wild woodchucks (Marmota Himalayana) in China. The genomic and molecular characterization of MHHAV indicated that it is most closely related genetically to HAV. MHHAV has wide tissue distribution but shows tropism for the liver. The virus is morphologically and structurally similar to HAV. The pattern of its codon usage bias is also consistent with that of HAV. Phylogenetic analysis indicated that MHHAV groups with known HAVs but forms an independent branch and represents a new species in the genus Hepatovirus within the family Picornaviridae. Antigenic site analysis suggested MHHAV has a new antigenic property to other HAVs. Further evolutionary analysis of MHHAV and primate HAVs led to a most recent common ancestor estimate of 1,000 years ago, while the common ancestor of all HAV-related viruses including phopivirus can be traced back to 1800 years ago. The discovery of MHHAV may provide new insights into the origin and evolution of HAV and a model system with which to explore the pathogenesis of HAV infection.
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- 2016
16. TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction
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Yi Liu, Yu Si, Sui Jun Chen, Guo Xu, Hao Xiong, Yi Qing Zheng, Huai Li Jiang, Xiang Liu, Yu Bin Chen, Zhuo Hao Li, Zhigang Zhang, and Qiu Hong Huang
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Adult ,Male ,Adolescent ,medicine.medical_treatment ,Osteoclasts ,Inflammation ,Cell Count ,Biology ,Article ,Bone and Bones ,Pathogenesis ,Young Adult ,Osteoclast ,medicine ,otorhinolaryngologic diseases ,Evoked Potentials, Auditory, Brain Stem ,Animals ,Humans ,Cholesteatoma ,Hearing Loss ,Aged ,Demography ,Multidisciplinary ,Bacteria ,Middle Aged ,medicine.disease ,Up-Regulation ,Mice, Inbred C57BL ,Toll-Like Receptor 4 ,TLR2 ,medicine.anatomical_structure ,Cytokine ,RANKL ,Immunology ,biology.protein ,TLR4 ,Cytokines ,Female ,medicine.symptom ,Inflammation Mediators - Abstract
Acquired cholesteatoma is a chronic inflammatory disease characterized by both hyperkeratinized squamous epithelial overgrowth and bone destruction. Toll-like receptor (TLR) activation and subsequent inflammatory cytokine production are closely associated with inflammatory bone disease. However, the expression and function of TLRs in cholesteatoma remain unclear.We observed inflammatory cell infiltration of the matrix and prematrix of human acquired cholesteatoma, as well as dramatically increased expression of TLR4 and the pro-inflammatory cytokines TNF-α and IL-1β. TLR2 exhibited an up-regulation that was not statistically significant. TLR4 expression in human acquired cholesteatoma correlated with disease severity; the number of TLR4-positive cells increased with an increased degree of cholesteatoma, invasion, bone destruction and hearing loss. Moreover, TLR4 deficiency was protective against experimental acquired cholesteatoma-driven bone destruction and hearing loss, as it reduced local TNF-α and IL-1β expression and impaired osteoclast formation by decreasing expression of the osteoclast effectors receptor activator of nuclear factor (NF)-κB ligand (RANKL) and tartrate-resistant acid phosphatase (TRAP). TLR2 deficiency did not relieve disease severity, inflammatory responses, or osteoclast formation. Moreover, neither TLR2 nor TLR4 deficiency had an effect on antimicrobial peptides, inducible iNOS,BD-2 expression or bacterial clearance. Therefore, TLR4 may promote cholesteatoma-induced bone destruction and deafness by enhancing inflammatory responses and osteoclastogenesis.
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- 2015
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17. 6.2-GHz modulated terahertz light detection using fast terahertz quantum well photodetectors
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Li, Hua, primary, Wan, Wen-Jian, additional, Tan, Zhi-Yong, additional, Fu, Zhang-Long, additional, Wang, Hai-Xia, additional, Zhou, Tao, additional, Li, Zi-Ping, additional, Wang, Chang, additional, Guo, Xu-Guang, additional, and Cao, Jun-Cheng, additional
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- 2017
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18. A New Strategy of Lithography Based on Phase Separation of Polymer Blends
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Guo, Xu, primary, Liu, Long, additional, Zhuang, Zhe, additional, Chen, Xin, additional, Ni, Mengyang, additional, Li, Yang, additional, Cui, Yushuang, additional, Zhan, Peng, additional, Yuan, Changsheng, additional, Ge, Haixiong, additional, Wang, Zhenlin, additional, and Chen, Yanfeng, additional
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- 2015
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19. Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach
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Dong, Yan, primary, Zhao, Qun, additional, Ma, Xiaoyan, additional, Ma, Guowu, additional, Liu, Caiyun, additional, Chen, Zhuwen, additional, Yu, Liyuan, additional, Liu, Xuefeng, additional, Zhang, Yanguang, additional, Shao, Shujuan, additional, Xiao, Jing, additional, Li, Jia, additional, Zhang, Weimin, additional, Fu, Ming, additional, Dong, Lijia, additional, Yang, Xiandong, additional, Guo, Xu, additional, Xue, Liyan, additional, Fang, Fei, additional, Zhan, Qimin, additional, and Zhang, Lihua, additional
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- 2015
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20. SNP rs2057482 in HIF1A gene predicts clinical outcome of aggressive hepatocellular carcinoma patients after surgery
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Guo, Xu, primary, Li, Deyang, additional, Chen, Yibing, additional, An, Jiaze, additional, Wang, Kan, additional, Xu, Zhuding, additional, Chen, Zhinan, additional, and Xing, Jinliang, additional
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- 2015
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21. Dislocation creation and void nucleation in FCC ductile metals under tensile loading: A general microscopic picture.
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Wei-Wei Pang, Ping Zhang, Guang-Cai Zhang, Ai-Guo Xu, and Xian-Geng Zhao
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NUCLEATION ,NUCLEATING agents ,HETEROGENOUS nucleation ,DISCONTINUOUS precipitation ,FLUCTUATIONS (Physics) - Abstract
Numerous theoretical and experimental efforts have been paid to describe and understand the dislocation and void nucleation processes that are fundamental for dynamic fracture modeling of strained metals. To date an essential physical picture on the self-organized atomic collective motions during dislocation creation, as well as the essential mechanisms for the void nucleation obscured by the extreme diversity in structural configurations around the void nucleation core, is still severely lacking in literature. Here, we depict the origin of dislocation creation and void nucleation during uniaxial high strain rate tensile processes in face-centered-cubic (FCC) ductile metals. We find that the dislocations are created through three distinguished stages: (i) Flattened octahedral structures (FOSs) are randomly activated by thermal fluctuations; (ii) The double-layer defect clusters are formed by self-organized stacking of FOSs on the close-packed plane; (iii) The stacking faults are formed and the Shockley partial dislocations are created from the double-layer defect clusters. Whereas, the void nucleation is shown to follow a two-stage description. We demonstrate that our findings on the origin of dislocation creation and void nucleation are universal for a variety of FCC ductile metals with low stacking fault energies. [ABSTRACT FROM AUTHOR]
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- 2014
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22. Nucleation and growth mechanisms of hcp domains in compressed iron.
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Wei-Wei Pang, Ping Zhang, Guang-Cai Zhang, Ai-Guo Xu, and Xian-Geng Zhao
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HEXAGONAL close packed structure ,NUCLEATION ,PHYSICAL & theoretical chemistry ,CRYSTAL structure ,NUCLEAR physics ,IRON - Abstract
In our previous work, we have pointed out that the shock-induced phase transition in iron occurs with the help of interface energy which reduces the potential barrier between two phases. Here, through studying the nucleation and growth mechanisms of hcp domains in compressed iron, we find that the flatted-octahedral-structure (FOS) is the primary structural unit of the embryo nucleus and phase interface of hcp domains, and the interfacial energy is reduced via formation of FOSs. The phase transition process can be described by the following four stages: (i) Some atoms deviate from their equilibrium positions with the aid of thermal fluctuations to form FOSs with two different deformation directions in the local region; (ii) FOSs with different deformation directions aggregate to form a thin stratified structure like twin-crystal configuration; (iii) The thin stratified structure undergoes a relative slip to form the new hcp phase; (iv) The hcp phase domain grows up through the formation of new FOSs along the phase boundary. In addition, through comparing the time evolution curves of initial single phase domain, we find that the growth rate of single phase domain depends on the loading way and its occurrence time. [ABSTRACT FROM AUTHOR]
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- 2014
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23. Morphology and growth speed of hcp domains during shock-induced phase transition in iron.
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Wei-Wei Pang, Ping Zhang, Guang-Cai Zhang, Ai-Guo Xu, and Xian-Geng Zhao
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PHASE transitions ,MOLECULAR dynamics ,IRON ,MICROSTRUCTURE ,MOLECULAR physics - Abstract
Emergence and time evolution of micro-structured new-phase domains play a crucial role in determining the macroscopic physical and mechanical behaviors of iron under shock compression. Here, we investigate, through molecular dynamics simulations and theoretical modelings, shock-induced phase transition process of iron from body-centered-cubic (bcc) to hexagonal-close-packed (hcp) structure. We present a central-moment method and a rolling-ball algorithm to calculate and analyze the morphology and growth speed of the hcp phase domains, and then propose a phase transition model to clarify our derived growth law of the phase domains. We also demonstrate that the new-phase evolution process undergoes three distinguished stages with different time scales of the hcp phase fraction in the system. [ABSTRACT FROM AUTHOR]
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- 2014
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24. The effectiveness of the puncture channel plugging for reduction of complications after CT-guided percutaneous transthoracic needle biopsy
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Dong-xu Wang, Yu-guang Wang, Guo-xu Ding, Bo Li, Rui-nan Liu, Zhong-wei Ai, and Yang Wang
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Medicine ,Science - Abstract
Abstract The effect of plugging the puncture channel with a mixture of hemocoagulase injection on the complications of CT-guided percutaneous transthoracic need biopsy (PTNB) was discussed. The medical records of PTNB were retrospectively studied from June 2017 to May 2022. In the study, the puncture channel of 626 patients were blocked, while remain 681 patients’ were not. The Mantel Haenszel method performed layered analysis and evaluated the correlation of adjusted confounding factors. The Odds Ratio and its 95% confidence interval were calculated using the Woof method. The incidence of high-level pulmonary hemorrhage was significantly reduced in patients with lesions ≤ 2 cm and different needle lengths. Patients with different pleural-needle tip angle and perineedle emphysema were blocked, and the incidence of pneumothorax and thoracic implants was significantly reduced. Through puncture channel plugging, the incidence of pulmonary hemorrhage, pneumothorax and thoracic catheterization of PTNB under CT guidance was reduced.
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- 2023
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25. miR-181a involves in the hippocampus-dependent memory formation via targeting PRKAA1
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Sun-fu Zhang, Jun-chen Chen, Jing Zhang, and Jian-guo Xu
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Medicine ,Science - Abstract
Abstract Post-transcriptional gene regulation by microRNAs (miRNAs) is involved in memory formation. However, the roles of individual miRNAs in these processes remain largely unknown. In this study, we want to clarify the role of miR-181a in hippocampus-dependent memory formation. A transient increase in miR-181a expression was observed after conditioned fear conditioning (CFC) and object location task (OLT) training. Selective overexpression or inhibition of miR-181a in the dorsal hippocampus (DH) via the injection of a miR-181a agomir or antagomir enhanced or impaired the CFC- and OLT-dependent memory formation, respectively. Using bioinformatics and luciferase assays, we identified PRKAA1 as a potential target gene of miR-181a. After CFC or OLT training, the expression and activity of PRKAA1 decreased as miR-181a expression increased and was effectively blocked by the miR-181a antagomir. Moreover, microinjection of the PRKAA1 agonist AICAR or inhibitor compound C in the DH reversed the roles of the miR-181a agomir or antagomir in CFC- and OLT-dependent memory formation. In conclusion, this work provides novel evidence describing the role and mechanism of miR-181a in hippocampus-dependent memory formation, which sheds light on the potential regulation of cognition and future treatments for cognitive disorders.
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- 2017
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26. Involvement of GATA1 and Sp3 in the activation of the murine STING gene promoter in NIH3T3 cells
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Yan-Yan Xu, Rui Jin, Guo-Ping Zhou, and Hua-Guo Xu
- Subjects
Medicine ,Science - Abstract
Abstract Stimulator of Interferon Gene (STING) is a key mediator of innate immune signaling. STING plays a pivotal role in the pathogenesis of many diseases including infectious diseases, auto-immune diseases and cancer. Many studies have been carried out recently in the field of STING-regulated pathway, however, rarely of transcriptional mechanisms. To characterize the murine STING (mSTING) promoter, we cloned a series of different nucleotide sequences of the 5′-flanking region of the mSTING gene. Transient transfection of promoter-reporter recombinant plasmids and luciferase assay illustrated the region (−77/+177) relative to the transcription start site (TSS) of the mSTING gene was sufficient for full promoter activity. This region contains GATA1, IK2, Sp1/Sp3 and STAT putative transcription factor binding sites. Mutation of GATA1 or Sp1/Sp3 sites led to obvious decrease of the mSTING promoter activity. Overexpression of GATA1 and Sp3 enhanced the mSTING promoter activity, whereas knockdown of GATA1 and Sp3 by a siRNA strategy significantly reduced the transcription activity. Chromatin immunoprecipitation assays demonstrated that GATA1 and Sp3 interact with the mSTING promoter in vivo. These results provided the first analysis of mSTING promoter and demonstrated that transcription factor GATA1 and Sp3 positively regulate the basal transcription of the mSTING gene.
- Published
- 2017
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