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A novel hepatovirus identified in wild woodchuck Marmota himalayana
- Source :
- Scientific Reports
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Hepatitis A virus (HAV) is a hepatotropic picornavirus that causes acute liver disease worldwide. Here, we report on the identification of a novel hepatovirus tentatively named Marmota Himalayana hepatovirus (MHHAV) in wild woodchucks (Marmota Himalayana) in China. The genomic and molecular characterization of MHHAV indicated that it is most closely related genetically to HAV. MHHAV has wide tissue distribution but shows tropism for the liver. The virus is morphologically and structurally similar to HAV. The pattern of its codon usage bias is also consistent with that of HAV. Phylogenetic analysis indicated that MHHAV groups with known HAVs but forms an independent branch and represents a new species in the genus Hepatovirus within the family Picornaviridae. Antigenic site analysis suggested MHHAV has a new antigenic property to other HAVs. Further evolutionary analysis of MHHAV and primate HAVs led to a most recent common ancestor estimate of 1,000 years ago, while the common ancestor of all HAV-related viruses including phopivirus can be traced back to 1800 years ago. The discovery of MHHAV may provide new insights into the origin and evolution of HAV and a model system with which to explore the pathogenesis of HAV infection.
- Subjects :
- 0301 basic medicine
Most recent common ancestor
Genotype
Picornavirus
viruses
Genome, Viral
Article
Virus
Evolution, Molecular
Epitopes
Open Reading Frames
03 medical and health sciences
Animals
Hepatovirus
Codon
Antigens, Viral
Phylogeny
Tropism
Genetics
Base Composition
Multidisciplinary
biology
Phylogenetic tree
fungi
virus diseases
Bayes Theorem
Genomics
biochemical phenomena, metabolism, and nutrition
Marmota himalayana
biology.organism_classification
Virology
digestive system diseases
030104 developmental biology
Marmota
Codon usage bias
Nucleic Acid Conformation
RNA, Viral
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....be612f83592e7942629e3c7571393ab8