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Your search keyword '"Metodieva, Verjinia D."' showing total 2 results
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2 results on '"Metodieva, Verjinia D."'

1. Human voltage-gated Na+ and K+ channel properties underlie sustained fast AP signaling.

Author

Wilbers, René, Metodieva, Verjinia D., Duverdin, Sarah, Heyer, Djai B., Galakhova, Anna A., Mertens, Eline J., Versluis, Tamara D., Baayen, Johannes C., Idema, Sander, Noske, David P., Verburg, Niels, Willemse, Ronald B., de Witt Hamer, Philip C., Kole, Maarten H. P., de Kock, Christiaan P. J., Mansvelder, Huibert D., and Goriounova, Natalia A.

Subjects
*SODIUM channels, *PYRAMIDAL neurons, *MEMBRANE potential, *ACTION potentials
Abstract

The article focuses on the biophysical properties of voltage-gated sodium (Na+) and potassium (K+) channels in human and mouse pyramidal neurons and their impact on the stability of action potentials (APs) during sustained firing. Human pyramidal neurons exhibit stable and fast AP kinetics, attributed to more depolarized voltage dependence, slower inactivation, and faster recovery from inactivation of Na+ channels, as well as right-shifted activation and inactivation curves of K+ channels.

Published
2023
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2. Structural and functional specializations of human fastspiking neurons support fast cortical signaling.

Author

Wilbers, René, Galakhova, Anna A., Driessens, Stan L. W., Heistek, Tim S., Metodieva, Verjinia D., Hagemann, Jim, Heyer, Djai B., Mertens, Eline J., Suixin Deng, Idema, Sander, de Witt Hamer, Philip C., Noske, David P., van Schie, Paul, Kommers, Ivar, Guoming Luan, Tianfu Li, Yousheng Shu, de Kock, Christiaan P. J., Mansvelder, Huibert D., and Goriounova, Natalia A.

Subjects
*INTERNEURONS, *SODIUM channels, *NEURONS, *EXCITATORY postsynaptic potential
Abstract

The article focuses on understanding the mechanisms underlying fast cortical signaling in human fast-spiking interneurons (FSINs). The study compares human and mouse FSINs, revealing that despite elongated dendrites in human FSINs, they maintain fast inhibition through adaptations such as stronger excitatory inputs, larger dendrite diameter with reduced complexity, faster action potential initiation, and faster and larger inhibitory output.

Published
2023
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