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Human voltage-gated Na+ and K+ channel properties underlie sustained fast AP signaling.
- Source :
-
Science Advances . 10/13/2023, Vol. 9 Issue 41, p1-14. 14p. - Publication Year :
- 2023
-
Abstract
- The article focuses on the biophysical properties of voltage-gated sodium (Na+) and potassium (K+) channels in human and mouse pyramidal neurons and their impact on the stability of action potentials (APs) during sustained firing. Human pyramidal neurons exhibit stable and fast AP kinetics, attributed to more depolarized voltage dependence, slower inactivation, and faster recovery from inactivation of Na+ channels, as well as right-shifted activation and inactivation curves of K+ channels.
- Subjects :
- *SODIUM channels
*PYRAMIDAL neurons
*MEMBRANE potential
*ACTION potentials
Subjects
Details
- Language :
- English
- ISSN :
- 23752548
- Volume :
- 9
- Issue :
- 41
- Database :
- Academic Search Index
- Journal :
- Science Advances
- Publication Type :
- Academic Journal
- Accession number :
- 172936984
- Full Text :
- https://doi.org/10.1126/sciadv.ade3300