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2. Binding of GGA2 to the Lysosomal Enzyme Sorting Motif of the Mannose 6-Phosphate Receptor.

Author

Yunxiang Zhu, Doray, Balraj, Poussu, Anssi, Lehto, Veli-Pekka, and Kornfeld, Stuart

Subjects
*PROTEINS, *CELL receptors, *LYSOSOMES
Abstract

Shows that the VHS domain of the GGA2 protein family binds to the acidic cluster-dileucine motif in the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR). Defects of receptors with mutations in the motif in lysosomal enzyme sorting; Hinge domain of GGA2 bound clathrin; Importance for lysosomal enzyme targeting.

Published
2001
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