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Your search keyword '"Jonas, E A"' showing total 14 results
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14 results on '"Jonas, E A"'

2. Protection from HIV infection or AIDS?

Author

Miedema, Frank, Meyaard, Linde, Klein, Michel R., Salk, Jonas E., Bretscher, Peter A., Salk, Peter L., and Shearer, Gene M.

Subjects
AIDS vaccines -- Research, Science and technology, Research
Abstract

One of the major goals research is the development of an efficacious vaccine providing broad, long-lasting protection against human immunodeficiency virus-type 1 (HIV-1) infection. In the past, for induction of [...]

Published
1993

3. A strategy for prophylactic vaccination against HIV

Author

Salk, Jonas E., Bretscher, Peter A., Salk, Peter L., Clerici, Mario, and Shearer, Gene M.

Subjects
Cellular immunity -- Research, AIDS vaccines -- Research, Science and technology, Research
Abstract

A prophylactic vaccine against human immunodeficiency virus (HIV) infection represents the best hope for controlling the continuing and devastating worldwide AIDS epidemic. In this commentary, we outline evidence suggesting that [...]

Published
1993

11. The Relation of Oxygen Uptake to Hemoglobin Synthesis

Author

Kurt Salomon, Jonas E. Richmond, and Kurt I. Altman

Subjects
chemistry.chemical_classification, Multidisciplinary, chemistry.chemical_element, Metabolism, Oxygen, Amino acid, Hemoglobins, chemistry.chemical_compound, chemistry, Biochemistry, Bone Marrow, Carbon-14, Globin, Hemoglobin, Quantitative analysis (chemistry), Hemin
Published
1951

13. A Simplified Procedure for the Concentration and Purification of Influenza Virus

Author

Jonas E. Salk and Thomas Francis

Subjects
Syndesmophyte, Ankylosing spondylitis, Multidisciplinary, medicine.diagnostic_test, business.industry, Radiography, medicine.medical_treatment, Computed tomography, medicine.disease, Virology, Intervertebral disk, Spinal fusion, medicine, Lumbar spine, sense organs, Sensitivity to change, skin and connective tissue diseases, business, Nuclear medicine
Abstract

Objectives Accurate measurement of syndesmophyte development and growth in ankylosing spondylitis (AS) is needed for studies of biomarkers and of treatments to slow spinal fusion. We tested the longitudinal validity and sensitivity to change of quantitative measurement of syndesmophytes using CT. Methods We performed lumbar spine CT scans on 33 patients with AS at baseline, 1 year and 2 years. Volumes and heights of syndesmophytes were computed in four intervertebral disk spaces. We compared the computed changes to a physician9s ratings of change based on CT scan inspection. Sensitivity to change of the computed measures was compared with that of the modified Stoke AS Spinal Score (radiography) and a scoring method based on MRI. Results At years 1 and 2, respectively 24 (73%) and 26 (79%) patients had syndesmophyte volume increases by CT. At years 1 and 2, the mean (SD) computed volume increases per patient were, respectively 87 (186) and 201 (366) mm3. Computed volume changes were strongly associated with the physician9s visual ratings of change (p Conclusions CT-based syndesmophytes measurements had very good longitudinal validity and better sensitivity to change than radiography or MRI. This method shows promise for longitudinal clinical studies of syndesmophyte development and growth.

Published
1942

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