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A Simplified Procedure for the Concentration and Purification of Influenza Virus
- Source :
- Science. 96:499-500
- Publication Year :
- 1942
- Publisher :
- American Association for the Advancement of Science (AAAS), 1942.
-
Abstract
- Objectives Accurate measurement of syndesmophyte development and growth in ankylosing spondylitis (AS) is needed for studies of biomarkers and of treatments to slow spinal fusion. We tested the longitudinal validity and sensitivity to change of quantitative measurement of syndesmophytes using CT. Methods We performed lumbar spine CT scans on 33 patients with AS at baseline, 1 year and 2 years. Volumes and heights of syndesmophytes were computed in four intervertebral disk spaces. We compared the computed changes to a physician9s ratings of change based on CT scan inspection. Sensitivity to change of the computed measures was compared with that of the modified Stoke AS Spinal Score (radiography) and a scoring method based on MRI. Results At years 1 and 2, respectively 24 (73%) and 26 (79%) patients had syndesmophyte volume increases by CT. At years 1 and 2, the mean (SD) computed volume increases per patient were, respectively 87 (186) and 201 (366) mm3. Computed volume changes were strongly associated with the physician9s visual ratings of change (p Conclusions CT-based syndesmophytes measurements had very good longitudinal validity and better sensitivity to change than radiography or MRI. This method shows promise for longitudinal clinical studies of syndesmophyte development and growth.
- Subjects :
- Syndesmophyte
Ankylosing spondylitis
Multidisciplinary
medicine.diagnostic_test
business.industry
Radiography
medicine.medical_treatment
Computed tomography
medicine.disease
Virology
Intervertebral disk
Spinal fusion
medicine
Lumbar spine
sense organs
Sensitivity to change
skin and connective tissue diseases
business
Nuclear medicine
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....5cb697d1ef5947e2f89760328a78e3fd