Search

Disorders of social functioning are the most persistent consequences of schizophrenia and are an important factor influencing the prognosis of mental disorders. Considering the role of HLA-G in modulating the immunological relationship between the mother and the fetus and, as a consequence, its role in the development of the embryonic brain, we studied the influence of the INDEL polymorphism of the HLA-G gene on the social functioning of patients with schizophrenia. The study included 812 people with schizophrenia and schizophrenia spectrum disorders. It was found that, in carriers of the D/D genotype, there is a decrease in the level of social functioning in all areas, which increases the risk of an unfavorable functional outcome. [ABSTRACT FROM AUTHOR]

By modulating the immunological relationship between the mother and the fetus, as well as interacting with various environmental factors, HLA-G plays an important role in the development of the brain of the embryo and is therefore considered as one of the risk factors for schizophrenia. We studied the relationship of INDEL HLA-G gene polymorphism with schizophrenia and its clinical features, taking into account the season of birth. The sample of patients included 1171 people with schizophrenia; the control group consisted of 575 mentally healthy people without a family history of mental disorders. The interaction of INDEL polymorphism and the season of birth was revealed. It has been found that, in men with the D/D genotype born in the summer, the risk of schizophrenia increases (OR = 1.95, 95% CI: 1.01–3.78). Our analysis has shown that the INDEL polymorphism does not interact with the season of birth as an environmental factor and does not affect the clinical features of schizophrenia: the age of onset of the disease and the severity of symptoms. [ABSTRACT FROM AUTHOR]