Investigation of the Relationship between Polymorphism of Human Leukocyte Antigen G (HLA-G) and Social Functioning of Patients with Schizophrenia.

Disorders of social functioning are the most persistent consequences of schizophrenia and are an important factor influencing the prognosis of mental disorders. Considering the role of HLA-G in modulating the immunological relationship between the mother and the fetus and, as a consequence, its role in the development of the embryonic brain, we studied the influence of the INDEL polymorphism of the HLA-G gene on the social functioning of patients with schizophrenia. The study included 812 people with schizophrenia and schizophrenia spectrum disorders. It was found that, in carriers of the D/D genotype, there is a decrease in the level of social functioning in all areas, which increases the risk of an unfavorable functional outcome. [ABSTRACT FROM AUTHOR]