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Her limb power was grade 0/5 in the right upper limb, grade 3/5 in right lower limb and 4/5 in the left limb. The aphasia and hemiplegia were suspected to be secondary to sodium chloride. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 24-year-old woman developed transient aphasia and hemiplegia during treatment with sodium chloride for hyponatraemia during pregnancy. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 55-year-old man developed acute kidney injury (AKI) during treatment with tenofovir disoproxil fumarate for chronic hepatitis B (CHB) [ I route and duration of treatment to reaction onset not stated i ]. Laboratory investigations revealed the following: blood urea nitrogen 92 mg/dL, serum creatinine concentration 15.7 mg/dL, urine creatinine 56.1 mg/dL, serum sodium 134 mEq/L; urine sodium 54 mEq/L; (fractional excretion of sodium 11.3%), potassium 5.3 mg/dL; serum calcium 8.6 mg/dL; phosphorus 7.3 mg/dL; serum uric acid, 8.7 mg/dL; urine uric acid, 24.8 mg/dL (fractional excretion of uric acid, 79.8%); a marked elevation in urinary 2-microglobulin with a urinary anion gap of 33.3 mEq/L: serum ALT 319 IU/L, serum albumin was 2.7 g/dL and prothrombin time was 1.03 INR. He was initiated on haemodialysis due to suspicion of oliguric AKI with metabolic acidosis. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event * Drug overdose A 40-year-old man developed multiple toxicities, including agitation, tachypnoea, tachycardia, whole-body pain, high anion gap metabolic acidosis, elevated lactate levels and cyanide toxicity following intentional overdose of amygdalin. Initial analyses of venous blood gases demonstrated compensated high anion gap metabolic acidosis secondary to elevated lactate due to cyanide toxicity (pH 7.32, pCO SB 2 sb 14mm Hg, HCO3 SP - sp 7 mmol/L, lactate 17 mmol/L and anion gap 26 mmol/L). [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 54-year-old woman developed pulmonary venoocclusive disease (PVOD) and hepatic venoocclusive disease (HVOD) during treatment with busulfan, cyclophosphamide, fludarabine and gemtuzumab ozogamicin as conditioning regimen before allogenic haematopoietic stem cell transplantation (allo-HSCT) [ I duration of treatments to reactions onsets not stated i ]. Right heart catheterization results were as follows: pulmonary arterial pressure 21mm Hg(31/14; systolic/diastolic), right atrial pressure 2mm Hg, pulmonary artery wedge pressure 2mm Hg, cardiac index 1.4 L/min/m SP 2 sp and pulmonary vascular resistance 8.0 wood units. Right heart catheterization results were as follows: pulmonary arterial pressure 26mm Hg(40/19; systolic/diastolic), right atrial pressure 2mm Hg, pulmonary artery wedge pressure 4mm Hg, cardiac index 3.0 L/min/m SP 2 sp and pulmonary vascular resistance 4.2 wood units. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 23-year-old pregnant woman developed acute pulmonary oedema following treatment with magnesium sulfate [ I route, dosage and indication not stated i ]. Thereafter, she underwent chest radiography, echocardiography, CT angiography, and complete work-up for autoimmune diseases and sepsis. Bedside chest radiograph revealed widespread interstitial shadowing, compatible with pulmonary oedema. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 25-year-old woman developed methaemoglobinaemia following administration of methylthioninium chloride during chromopertubation. However, on chromopertubation with an injection of methylthioninium chloride [methylene blue dye; I route and dosage not stated i ], the tubes appeared bilaterally patent, without free spillage of dye. However, subsequent test results, including normal chest X-ray, echocardiography, CT angiography and G6PD levels, eliminated the possibility of a pulmonary embolism or G6PD deficiency. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A case report described a 46-year-old man and a 60-year-old man, who developed rhabdomyolysis and respiratory insufficiency during treatment with methylprednisolone for suspected polymyositis. His plasma lactic acid was 5.0 mmol/L. Results of further investigations were as follows: AST 7241 IU/L, ALT 1343 IU/L and LDH 13 508 IU/L; these results indicated rhabdomyolysis and respiratory insufficiency. [Extracted from the article]

A case series described three patients (2 men and 1 woman) aged 61-76 years, who developed interstitial lung diseases (ILD) during treatment with riluzole for amyotrophic lateral sclerosis [ALS; I routes not stated i ]. Riluzole-associated ILD was diagnosed; hence, riluzole was discontinued after 11 weeks of its initiation. [Extracted from the article]

A 31-year-old man became unresponsive and developed diffuse alveolar haemorrhage following overdose of fentanyl-adulterated cocaine. Fentanyl metabolite panel confirmed fentanyl levels at 2.3 ng/mL and norfentanyl levels at 1.45 ng/mL. [Extracted from the article]

A 25-year-old woman developed acquired methemoglobinemia following the treatment with benzocaine for toothache. At presentation, her physical examination showed cyanosis and dark arterial and venous blood. Arterial blood gases analysis showed arterial oxygen of 120mm Hg and methemoglobin of 44%. [Extracted from the article]

A 39-year-old woman developed metabolic acidosis during diuresis with acetazolamide. Analysis of arterial blood gases showed decompensation of metabolic acidosis. B Author comment: b I "[P]rescribing acetazolamide should be under [arterial blood gases] control due to possible metabolic changes, especially metabolic acidosis." i. [Extracted from the article]

The article describes the case of a 72-year-old man who experienced metabolic acidosis and renal functional aggravation after isoniazid treatment. Topics covered include the patient's presentation with generalised weakness and loss of appetite, the results of his arterial blood gas analysis and abdominal sonography and the complete withdrawal of isoniazid.

The article describes the case of 73-year-old man who developed fatal lactic acidosis after a metformin overdose. Particular focus is given to his medical history. His other medications included gliclazide and perindopril. Sinus tachycardia was detected via an electrocardiogram. The results of his arterial blood gas analysis and other laboratory tests are also provided. He experienced persistent hypotension and worsening metabolic acidosis. The patient died several hours after presentation.

The article reports findings from four case studies on the adverse effects of indigotindisulfonate sodium, methylthioninium or sulphan blue. Four patients developed methaemoglobinaemia with decreased oxygen saturation and facial discolouration after receiving these drugs. The patients' faces turned a blue to purple-grey color with decreased hemoglobin levels based from an arterial blood gas analysis.

Presents the case of a man who developed malignant hyperthermia during anaesthesia with sevoflurane. Medical history of the patient; Rectal temperature and results of his arterial blood gas analysis after taking anaesthesia.

The article describes the case of a 14-year-old boy with a glucose-6-phosphate dehydrogenase (G6PD) deficiency who developed methaeglobinaemia and haemolytic anaemia during rasburicase therapy. Other medications received by the patient are cited. His symptoms were cyanosis and an oxygen saturation of 80%. Particular focus is given to the result of his capillary blood gas analysis.

The article presents a case study involving ingestion of an overdose of paracetamol associated with metabolic acidosis and coma in a 27-month-old-girl, despite her liver function tests remaining normal. Arterial blood gas analysis was conducted. The medical condition of the girl after arrival at the emergency department is described.

Discusses research being done on an adverse reaction of the drug nimesulide. Reference to a study by D. W. Perng, H. T. Su, C. W. Tseng and Y. N. Lee, published in a 2005 issue of "Respiration"; Complications experienced by a woman after starting nimesulide; Findings of blood gas analysis.

Discusses research being done on respiratory failure due to Pneumocystis carinii following methotrexate therapy for gestational trophoblastic disease. Reference to a study by C. Barbier, L. Arnaout, C. Schmit, J. S. Aucouturier, J. L. Ricome et al., published in the March 2005 issue of "An International Journal of Obstetrics and Gynaecology"; Results of arterial blood gas analysis; Treatment which helped improve respiratory function.

Discusses research being done on the manifestation of methaemoglobinaemia following the use of a benzocaine-containing anesthetic spray for endoscopic retrograde cholangiopancreatography procedures. Reference to a study by M. F. Byrne et al, published in the March 2004 issue of the "Journal of Clinical Gastroenterology"; Range of oxygen saturation from the results of the arterial blood gas analysis; Increase in oxygen delivery among the patients.

Discusses research being done on the development of lactic acidosis associated with an overdose of metformin. Reference to a study by P. Nisse and colleagues, published in a 2003 issue of the "Journal of Toxicology--Clinical Toxicology"; Findings of an arterial blood gas analysis conducted on the patient; Conclusion of the study.

Discusses research being done on the occurrence of methaemoglobinaemia following oropharyngeal anaesthesia with benzocaine prior to transoesophageal echocardiography. Reference to a study by R. Sachdeva et al, published in a 2003 issue of the "Texas Heart Institute Journal"; Percentage of topical benzocaine spray administered to the patients; Oxygen saturation revealed by the arterial blood gas analysis conducted to the patients.