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Start Over Author "Hudis, Clifford A." Topic therapeutics Journal prostaglandins & other lipid mediators

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1. Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis.

Author

Howe, Louise R., Subbaramaiah, Kotha, Kent, Claire V., Zhou, Xi K., Chang, Sung-Hee, Hla, Timothy, Jakobsson, Per-Johan, Hudis, Clifford A., and Dannenberg, Andrew J.

Subjects
*DELETION mutation, *CYCLOOXYGENASES, *DEVELOPMENT of mammary glands, *NEOVASCULARIZATION, *TUMOR suppressor genes, *LABORATORY mice, *AROMATASE, *THERAPEUTICS
Abstract

Highlights: [•] Knocking out mPGES-1 suppresses mouse mammary tumor growth. [•] Angiogenesis is reduced by genetic ablation of mPGES-1. [•] Aromatase activity is substantially reduced in mPGES-1-deficient mammary glands. [ABSTRACT FROM AUTHOR]

Published
2013
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