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Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis.

Authors :
Howe, Louise R.
Subbaramaiah, Kotha
Kent, Claire V.
Zhou, Xi K.
Chang, Sung-Hee
Hla, Timothy
Jakobsson, Per-Johan
Hudis, Clifford A.
Dannenberg, Andrew J.
Source :
Prostaglandins & Other Lipid Mediators. Oct2013, Vol. 106, p99-105. 7p.
Publication Year :
2013

Abstract

Highlights: [•] Knocking out mPGES-1 suppresses mouse mammary tumor growth. [•] Angiogenesis is reduced by genetic ablation of mPGES-1. [•] Aromatase activity is substantially reduced in mPGES-1-deficient mammary glands. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10988823
Volume :
106
Database :
Academic Search Index
Journal :
Prostaglandins & Other Lipid Mediators
Publication Type :
Academic Journal
Accession number :
92655731
Full Text :
https://doi.org/10.1016/j.prostaglandins.2013.04.002