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Objective: To investigate the relationship between serum apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio, triacylglycerol (TG)/high density lipoprotein cholesterol (HDL-C) ratio, lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) levels and the severity of coronary artery disease in patients with coronary heart disease (CHD) and their predictive value. Methods: 185 patients who were admitted to our hospital for chest pain from January 2019 to December 2021 were selected, and they were divided into CHD group (120 cases) and control group (65 cases) according to the examination results. According to Gensini score, the CHD group was divided into mild stenosis subgroup with 36 cases, moderate stenosis subgroup with 55 cases and severe stenosis subgroup with 29 cases. Serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels were measured after admission. Spearman correlation coefficient was used to analyze the correlation between serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH, ALP level and Gensini score in patients with CHD, and multivariate logistic regression was used to analyze the influencing factors of CHD. The predictive value of serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels on CHD was analyzed by the ROC curve. Results: Compared with the control group, the proportion of smoking, alcohol consumption, hypertension, diabetes mellitus and serum total cholesterol (TC), TG, low density lipoprotein cholesterol (LDL-C), ApoB, ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels in the CHD group were increased, the HDL-C and ApoA1 levels were decreased (P＜0.05). Serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels in mild, moderate and severe stenosis groups were increased successively (P＜0.05). Serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels were positively correlated with Gensini score in patients with CHD (all P＜0.001). Multivariate Logistic regression analysis showed that hypertension, serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels increased were independent risk factors for CHD (P＜0.05). ROC curve analysis showed that the combined prediction of ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels of CHD was larger than alone (P＜0.05). Conclusion: Serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels are related to the severity of coronary artery disease in CHD patients, and the value of joint prediction of CHD is high. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To observe the effects of Jiangtangsanhao (JTSH) formula on body weight, blood glucose, serum insulin content, glucose tolerance and blood lipid in diet induced obese mice, and to explore its effects on PI3K/AKT signaling pathway in the skeletal muscle. Methods: Eight-week-old C57BL/6J mice were fed with high-fat feed for 12 consecutive weeks to induce obesity model. Then the mice were randomly divided into model control group, metformin group and JTSH formula group. The mice fed with normal diet were used as normal control group. All the mice received 8 weeks of intervention by gavage. and the normal and model group received the same amount of sterile water. Body weight and fasting blood glucose were measured every 2 weeks: oral glucose tolerance test was performed 7 weeks later. Samples were taken after the drug intervention and the levels of HbAlc. Insulin, TC. TG. LDL-C and HDL-C were detected. The expressions of PI3K. AKT and GLUT4 in skeletal muscle were detected by Western Blot. Results: JTSH formula could significantly reduce the body weight of obese mice (P < 0.05): it could also effectively reduce the fasting blood glucose of obese mice to the normal level (P < 0.05): As to indicators like HbAlc. INS. TC. LDL-C. the mice in JTSH formula group were much lower than the model group (P < 0.05). According to the results of oral glucose tolerance test (OGTT). the glucose tolerance of those experimental animals were improved after the intervention of JTSH formula (P < 0.05). Western blot analysis showed that JTSH formula could up-regulate the expression of PI3K. AKT. GLUT4 compared with model group (P < 0.05). Conclusions: JTSH formula can effectively reduce the weight of obese mice, improve the metabolism of glucose and lipid, and reduce the level of insulin. Its effect may be achieved by activating PI3K AKT signaling pathway. [ABSTRACT FROM AUTHOR]

Objective: To study the effect of Yinchen Siling Granule on liver differentiation and IDO protein expression of bone marrow mesenchymal stem cells(BMSCs) in vitro model of hepatic failure. Methods: The co-culture system of hepatic failure serum,traditional Chinese medicine(TCM) serum and healthy serum with bone marrow mesenchymal stem cells(BMSCs) was established. The expression of CK18 in BMSCs was detected by immunofluorescence, and the expression of alpha-fetoprotein(AFP), hepatic albumin(ALB) and indoleamine 2-, 3-dioxygenase(IDO) protein were detected by Western-blot. Results: 1. The results of CK18 immunofluorescence showed that the staining of hepatic failure group and TCM group were weakly positive, and the latter staining was deeper. The healthy group had no positive staining; 2. The expressions of AFP, ALB were found in the healthy group, hepatic failure group and TCM group. There was significant difference in ALB expression among the three groups(P<0.05). The expression level of AFP in the three groups increased gradually, and there was significant difference among the three groups. There was no expression of IDO protein in the healthy group, but the expression in the hepatic failure group was lower than that in the TCM intervention group, and the difference between the two groups was statistically significant. Conclusion: Yinchen Siling Granule can enhance the liver differentiation trend and immunomodulatory activity of BMSCs in hepatic failure. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the application and advantages of Vibrant technology on bilateral breast dynamic contrast-enhanced magenetic resonance imaging. Methods: Applying retrospective analysis method, 70 cases of patients with breast disease by surgery or biopsy proven were women, divided into group A and group B according to the scanning time of dynamic enhancement( all n=35). All the cases were examined by 1.5T MR. The dynamic contrast-enhanced scanning time of group A was 9minutes and 24 seconds, and the dynamic contrast-enhanced scanning time of group B was 7 minutes and 42 seconds. Results: The sensitivity, specificity and accuracy of group A diagnosed were 94.74%, 85% and 89.74% respectively. The sensitivity, specificity and accuracy of group B diagnosed were 91.3%, 89.47% and 90.48% respectively. There was no significant difference between group A and group B on sensitivity, specificity and accuracy(P>0.05). Conclusions: Vibrant breast dynamic contrast-enhanced scanning technology,with higher sensitivity, specificity and accuracy plays an important role in the diagnosis of breast disease. Additionally, this technique did not reduce diagnostic efficacy under shorter scanning time. [ABSTRACT FROM AUTHOR]

Atrial fibrillation(AF) was one of the most common arrhythmias. In order to prevent and control atrial fibrillation and its complications, many researches had been performed in the epidemiology of AF. It was shown that the morbidity and incidence rate of AF increased with the age, especially in 80 years and older; men’s morbidity of AF was always higher than women’s. The risk factors of AF were not just limited to the acknowledged factors such as age, hypertension, diabetes, obesity and so on, the hyperuricemia, obstructive sleep apnea, strenuous exercise, climate were also identified. The studies on AF in our country was later than overseas, which focused on the cross-sectional study, and no large-scale longitudinal clinical studies had been conducted and compared with the foreign studies. AF can lead to stroke, heart failure, cognitive dysfunction and even death. In this article, the status and progress on epidemiological studies of atrial fibrillation, risk factors, and adverse effects were reviewed. [ABSTRACT FROM AUTHOR]

Cell migration is the base of some physiological and pathological activities such as immune response, wound healing and cancer metastasis. G protein-coupled receptor kinases are a family of protein kinases that regulate the activity of G protein-coupled receptors(GPCRs) by phosphorylating them, in which GRK2 is distributed the most-widely and studied. Many studies have found that GRK2 plays an important role in the regulation of cell migration by interaction with multiple substrates. This review will summarize research findings about the relationship between GRK2 and cell migration, and try to provide some reference for future studies. [ABSTRACT FROM AUTHOR]

Objective: To study the effect of laser combined with ultraviolet rays in treatment of patients with pressure ulcer at stage II and stage III. Methods: Retrospectively analyzed the clinical records of 59 patients with pressure ulcer at stage II and III treated in our department from July 2010 to July 2014, the patients were classified into control group(n=30,) and combination group(n=29), the control group was treated with traditional nursing on the basis of basic therapy, while the combination group was treated with laser combined with ultraviolet rays on the basis of basic therapy, after 14 days of treatment, the effect of two groups were compared, which was evaluated by pressure ulcer scale for healing(PUSH) score. Results: The PUSH score of two groups were decreased after treatment than before treatment, and the decrease variation in combination group was bigger than control group, the differences were statistically significant(P<0.001). Conclusion: Laser combined with ultraviolet rays has significant promotion on the recovery of patients with pressure ulcer at stage II and stage III, which should be recommended in clinical field. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the clinical effects of vinpocetine and enzyme on the treatment of sudden deafness. Methods: 140 elderly patients with sudden deafness who were treated in our hospital were selected and randomly divided into two groups with 70 cases in each group. The patients in the study group were treated with vinpocetine and enzyme, while the patients in the control group were given the enzyme. Then the clinical effects, blood rheology indexes and PTA values of patients in the two groups were observed and compared before and after the treatment. Results: The clinical effect of patients in the study group was significantly higher than that of the control group with statistically significant differences (P<0.05); Compared with before, the hemorheology indexes, high viscosity, low viscosity and red blood cells deposited level of patients in the two groups obviously improved, and the study group was better than that of the control group, and the differences were statistically significant (P<0.05); The PTA value of patients in the two groups decreased than before, and the study group was lower than that of the control group with statistically significant differences (P<0.05). Conclusion: Vinpocetine and enzymes in the treatment of sudden deafness has better curative effect, which can effectively improve the index of blood rheology in patients with level and vascular microcirculation and inhibiting thrombosis. [ABSTRACT FROM AUTHOR]