血清ApoB/ApoA1比值、TG/HDL-C比值、LDH及ALP水平与冠心病患者冠状动脉病变严重程度的关系及其预测价值分析.

Objective: To investigate the relationship between serum apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio, triacylglycerol (TG)/high density lipoprotein cholesterol (HDL-C) ratio, lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) levels and the severity of coronary artery disease in patients with coronary heart disease (CHD) and their predictive value. Methods: 185 patients who were admitted to our hospital for chest pain from January 2019 to December 2021 were selected, and they were divided into CHD group (120 cases) and control group (65 cases) according to the examination results. According to Gensini score, the CHD group was divided into mild stenosis subgroup with 36 cases, moderate stenosis subgroup with 55 cases and severe stenosis subgroup with 29 cases. Serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels were measured after admission. Spearman correlation coefficient was used to analyze the correlation between serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH, ALP level and Gensini score in patients with CHD, and multivariate logistic regression was used to analyze the influencing factors of CHD. The predictive value of serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels on CHD was analyzed by the ROC curve. Results: Compared with the control group, the proportion of smoking, alcohol consumption, hypertension, diabetes mellitus and serum total cholesterol (TC), TG, low density lipoprotein cholesterol (LDL-C), ApoB, ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels in the CHD group were increased, the HDL-C and ApoA1 levels were decreased (P＜0.05). Serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels in mild, moderate and severe stenosis groups were increased successively (P＜0.05). Serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels were positively correlated with Gensini score in patients with CHD (all P＜0.001). Multivariate Logistic regression analysis showed that hypertension, serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels increased were independent risk factors for CHD (P＜0.05). ROC curve analysis showed that the combined prediction of ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels of CHD was larger than alone (P＜0.05). Conclusion: Serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels are related to the severity of coronary artery disease in CHD patients, and the value of joint prediction of CHD is high. [ABSTRACT FROM AUTHOR]