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To investigate the correlation analysis of serum C-C chemokine ligand 17 (CCL17), CXC chemokine receptor 4 (CXCR4) and helper T cell (Th) 17 in patients with severe pre-eclampsia (SPE) and their effects on maternal and infant outcomes. 169 patients with SPE (SPE group) and 77 healthy pregnant women (control group) who were admitted to the Obstetrics and Gynecology Department of the Second Affiliated Hospital of Soochow University from March 2018 to March 2021 were selected. The serum CCL 17 and CXCR4 levels as well as peripheral blood Th17 cell and their cytokines were detected, and the maternal and infant outcomes were analyzed. The relationship between serum CCL 17 and CXCR4 levels and peripheral blood Th17 cell and their cytokines were analyzed by Pearson, and multivariate Logistic regression was used to analyze the related factors of poor maternal and infant outcomes of SPE. The serum CCL17 and CXCR4 levels in the SPE group were lower than those in the control group (P＜0.05), and the proportion of peripheral blood Th17 cell and the serum interleukin (IL) -17 level were higher than those in the control group(P＜0.05). Serum CCL17 and CXCR4 levels were negatively correlated with the proportion of peripheral blood Th17 cell and serum IL-17 level (P＜0.05). There were 53 cases with poor maternal and infant outcomes, and 116 cases with good maternal and infant outcomes. The CCL 17 and CXCR4 levels in the poor maternal and infant outcome group were lower than those in the good maternal and infant outcome group(P＜0.05). High proportion of Th17 cell, old age, low CCL17 and CXCR4 level were risk factors for adverse maternal and infant outcomes in patients with SPE (P＜0.05). The serum CCL17 and CXCR4 levels in patients with SPE are decreased, which are associated with increased proportion of peripheral blood Th17 cell, increased serum IL-17 level, and adverse maternal and infant outcomes. Low levels of CCL17 and CXCR4 are risk factors for adverse maternal and infant outcomes in patients with SPE. [ABSTRACT FROM AUTHOR]

Objective: To explore the clinical application value of low dose spiral CT combined with lung cancer autoantibody and tumor markers carbohydrate antigen (CA) 12-5 and CA19-9 in the diagnosis of lung cancer. Methods: A total of 86 patients with lung lesions detected by low dose spiral CT examination in our hospital from January 2019 to December 2021 were selected. According to pathological diagnosis results, they were divided into lung cancer group with 49 cases and benign lung lesions group with 37 cases,another 30 healthy volunteers in the same period were selected as the control group. Low dose spiral CT imaging characteristics of lung cancer were observed, and serum levels of lung cancer autoantibodies [p53, SOX region Y-associated HMG protein family member 2 (SOX2), G antigen 7 (GAGE7), RNA helicase autoantibodies 4-5 (GBU4-5)] and CA12-5 and CA19-9 were detected and compared in each group. The positive expression was compared, the diagnostic value of low dose spiral CT combined with lung cancer autoantibody,CA12-5 and CA19-9 in lung cancer were analyzed. Results: A total of 51 lesions were found in 49 patients with lung cancer by low dose spiral CT, including 30 solid or partially solid nodules, and 21 non-solid nodules. The mean diameter of lesions was (10.92±1.17) mm, 9lesions were < 5 mm, 17 lesions were 5～10 mm, and 25 lesions were ≥10 mm. 11 lesions had calcification, 16 lesions had burr sign,and 20 lesions had lobulation sign. There were 6 cases of cavity, usually with uneven wall thickness, centrality or eccentricity. The serum levels of p53, SOX2, GAGE7, GBU4-5, CA12-5 and CA19-9 in lung cancer group were significantly higher than those in benign lung lesions group and control group, the levels of above indexes in benign lung lesions group were significantly higher than those in control group (P<0.05）. The positive rates of CA12-5, CA19-9 and 4 items lung cancer autoantibodies alone and in combination in lung cancer group were significantly higher than those in benign lung lesions group and control group (P<0.05). The positive rates of CA12-5,CA19-9 and 4 items lung cancer autoantibodies in combination in benign lung lesions group were significantly higher than those in control group (P<0.05). The sensitivity of low dose spiral CT combined with 4 items lung cancer autoantibodies, CA12-5 and CA19-9 in the diagnosis of lung cancer was 91.84%, the specificity was 97.30%, the accuracy was 94.19%. Conclusion: Low dose spiral CT combined with lung cancer autoantibody, tumor markers CA12-5 and CA19-9 has good clinical application value in the diagnosis of lung cancer. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To study the expression and clinical significance.of TLR9 mediated Myd88 signaling pathway in patients with missed abortion. Methods: The villi tissue of missed abortion patients and normal delivery were collected. Real- time PCR and Western blot method were used to detect the mRNA and protein expression of TLR9, Myd88, TNF-a, NF-κB, IRF1. Results: Compared with normal control group, the mRNA and protein expression of TLR9, Myd88, TNF-a, NF-κB, IRF1 were significantly raised in the abortion group(P<0.05). Conclusion: TLR9/MyD88 signaling pathway might be involved in the pathogenesis of missed abortion. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the real-time ultrasound elastography (Realtime tissue elastograph, RTE) on the value of clinical diagnosis of chronic hepatitis B combined with liver fibrosis. Methods: 100 cases of chronic hepatitis B patients with hepatic fibrosis were selected in clinical, on the RTE and liver biopsy examination, contrast and analyze the RTE score and pathological result. Results: With the increase of S staging of patients with chronic hepatitis B combined with liver fibrosis, RTE score results also gradually rised, the RTE score results and pathological staging of liver fibrosis was significantly positively related (r=0.665, P<0.01). The sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value of, Real-time ultrasound elastography in the diagnosis of chronic hepatitis B combined with liver fibrosis were 92.31%, 91%,96%, 96% and 76.00% respectively. Conclusion: Real-time ultrasound elasticity imaging as a non-invasive examination technology, has a higher value in clinical diagnosis of chronic hepatitis B combined with liver fibrosis. [ABSTRACT FROM AUTHOR]