TLR9介导的Myd88信号通路分子在稽留流产患者绒毛组织中的表达及其临床意义.

Objective: To study the expression and clinical significance.of TLR9 mediated Myd88 signaling pathway in patients with missed abortion. Methods: The villi tissue of missed abortion patients and normal delivery were collected. Real- time PCR and Western blot method were used to detect the mRNA and protein expression of TLR9, Myd88, TNF-a, NF-κB, IRF1. Results: Compared with normal control group, the mRNA and protein expression of TLR9, Myd88, TNF-a, NF-κB, IRF1 were significantly raised in the abortion group(P<0.05). Conclusion: TLR9/MyD88 signaling pathway might be involved in the pathogenesis of missed abortion. [ABSTRACT FROM AUTHOR]