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Objective: To explore the influence of butorphanol pretreatment combined with ultrasound-guided thoracic paraverte- bral nerve block anesthesia (TPVB) on analgesic effect and stress response in patients undergoing thoracoscopic radical resection of lung cancer. Methods: Sixty patients with lung cancer in our hospital were selected from May 2021 to June 2022 and were classified into ob- servation group (n=30) and control group (n=30) by random number table method. Both groups received intravenous anesthesia and were treated with patient-controlled intravenous analgesia (PCIA) after surgery, and the observation group performed ultrasound-guided TPVB before surgery and was given butorphanol pretreatment. The hemodynamics, anesthetic effect, postoperative pain status, stress response and occurrence of adverse reactions were compared between the two groups. Results: Compared with To, the heart rate (HR) and mean arterial pressure (MAP) in the two groups were decreased at T1 (P<0.05). The HR and MAP were increased at T2 in the two groups compared with those at T 1(P<0.05). The HR and MAP at T2 and T3 in observation group were lower compared to control group (P<0.05). The propofol dosage, remifentanil dosage, extubation time and PCIA use frequency in observation group were lower, shorter or less than those in control group (P<0.05). At 8 h, 12 h and 24 h after surgery, the pain degrees at rest and cough in observation group were milder than those in control group(P<0.05). After surgery, the levels of epinephrine (E), cortisol (Cor) and adrenocorticotropic hormone (ACTH) were risen in the two groups (P<0.05), but the observation group had lower levels (P<0.05). There was no significant difference in the total incidence rate of adverse reactions between the two groups (P>0.05). Conclusion: Butorphanol pretreatment combined with ultrasound-guided TPVB can control the hemodynamics and total dosage of opioids of patients undergoing thoracoscopic radical resection of lung cancer, shorten the extubation time, and relieve the postoperative pain and stress response. [ABSTRACT FROM AUTHOR]

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Objective: To investigate the clinical effect of visual function training combined with topicamide eye drops in the treatment of pseudo myopia. Methods: 400 cases of children with pseudomyopia admitted to the ophthalmology department of the army characteristic medical center of the Chinese people's liberation army and the ophthalmology department of Chongqing you baby women's and children's hospital were selected as the research objects from February 2019 to Agust 2019. They were randomly divided into the control group and the observation group (n=200). The control group was treated with eye drops to relieve eye fatigue, while the observation group was treated with visual training combined with compound topicamide eye drops. The visual acuity, axial length, diopter, positive and relative adjustment, and visual fatigue score were measured and compared between two groups before and after treatment. Results: After 2 month and 6 months of treatment, the visual acuity of the children in the observation group was (0.75± 0.05) and (0.81± 0.04), which was significantly higher than that of the control group (P<0.05). The diopters of children were (+0.05± 0.50) and (+0.06± 0.48), respectively, and the improvement was significantly better than that of the control group (P<0.05). The test results of the positive relative regulation quantity were (-1.98± 0.07) and (-2.51± 0.24) respectively, which were significantly better compared with the control group (P<0.05). The visual perception binocular visual function of two groups improved significantly, and the visual function recovery of observation group was significantly higher than that of control group (P<0.05). The investigation of visual fatigue showed that the scores of visual fatigue in the observation group were (6.90± 0.89) and (3.91± 0.89), which were significantly lower than those in the control group (P<0.05). Conclusion: Visual function training combined with compound topicamide eye drops could effectively improve children's naked eye vision, and promote diopter, positive relative adjustment and V visual perception function, which reduced visual fatigue and prevented myopia. [ABSTRACT FROM AUTHOR]

To investigate the clinical effect of visual function training combined with topicamide eye drops in the treatment of pseudo myopia. 400 cases of children with pseudomyopia admitted to the ophthalmology department of the army characteristic medical center of the Chinese people's liberation army and the ophthalmology department of Chongqing you baby women's and children's hospital were selected as the research objects from February 2019 to Agust 2019. They were randomly divided into the control group and the observation group (n=200). The control group was treated with eye drops to relieve eye fatigue, while the observation group was treated with visual training combined with compound topicamide eye drops. The visual acuity, axial length, diopter, positive and relative adjustment, and visual fatigue score were measured and compared between two groups before and after treatment. After 2 month and 6 months of treatment, the visual acuity of the children in the observation group was (0.75± 0.05) and (0.81± 0.04), which was significantly higher than that of the control group (P<0.05). The diopters of children were (+0.05± 0.50) and (+0.06± 0.48), respectively, and the improvement was significantly better than that of the control group (P<0.05). The test results of the positive relative regulation quantity were (-1.98± 0.07) and (-2.51± 0.24) respectively, which were significantly better compared with the control group (P<0.05). The visual perception binocular visual function of two groups improved significantly, and the visual function recovery of observation group was significantly higher than that of control group (P<0.05). The investigation of visual fatigue showed that the scores of visual fatigue in the observation group were (6.90± 0.89) and (3.91± 0.89), which were significantly lower than those in the control group (P<0.05). Visual function training combined with compound topicamide eye drops could effectively improve children's naked eye vision, and promote diopter, positive relative adjustment and V visual perception function, which reduced visual fatigue and prevented myopia. [ABSTRACT FROM AUTHOR]

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Objective: To analyze the risk factors for gastric stump cancer of peptic ulcer patients after accepting the subtotal gastrectomy and propose corresponding intervention measures. Methods: 180 patients with peptic ulcer disease after accepting the subtotal gastrectomy and randomly were divided into 2 groups. Provide the regular intervention for the control group and provide comprehensive intervention for observation group to obverse the intervention effects. Compare each detail information of patient with gastric stump cancer with that of patient without gastric stump cancer to obverse the risk factors causing gastric stump cancer. Results: There were no cases of gastric stump cancer in the observation group and 10 cases in the control group (11.11%, P<0.05), and there was no significant difference in the age and sex of HP infection between the two groups (P>0.05). There were significant differences between the two groups in the anastomosis of the first operation and the location of ulcer in the first operation (P<0.05). In the gastric stump gastric cancer group, there were 2 cases of type I and 1 case of type II Roux-Y, and 82 cases of type I were used in the group without residual gastric cancer. A report of 74 cases of Bi II type Roux-Y type 14 In the gastric stump group, duodenal bulbar was the main location of ulcer in the first operation, and the duodenal bulbar and gastric body were the main anastomosis in the gastric remnant group. The results of logistic regression analysis confirmed the anastomosis of the first operation. The location of ulcer in the first operation is the main risk factor of gastric stump cancer. Conclusions: The risk factors that may cause gastric stump cancer after surgery include the surgical anastomosis kinds and surgical ulcer position of the first surgery. Meanwhile, the incidence of related complications will also increase the gastric stump cancer incidence rate. Therefore, the comprehensive intervention plan, including strengthening drainage tube intervention and complications intervention, shall be established based on this. [ABSTRACT FROM AUTHOR]

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Objective: To investigate the role of microRNA-21(miR-21) in the proliferation and invasion potential of osteosarcoma cell lines U2OS and the exact underlying mechanism. Methods: The expression level of miR-21 in human osteosarcoma tissues and adjacent normal bone tissues was detected by real-time PCR(qRT-PCR). Osteosarcoma cells U2OS were transfected with chemically-synthesized miR-21 mimics and mi R-NC, the expression of miR-21 and β-catenin were determined by qRT-PCR and western blot. The specific binding ability of miR-21 to β-catenin 3’-UTR was theoretically predicted and detected by the dual luciferase reporter gene assay. Moreover, the proliferation and invasion of U2OS cells were detected by MTT and Transwell assay. Results: The expression levels of miR-21 was higher in human osteosarcoma tissues compared to adjacent normal bone tissues(P <0.05). miR-21 directly up-regulates the m RNA and protein expression levels of β-catenin(P<0.05) and promotes proliferation and invasion abilities of U2OS cells. Luciferase reporter gene assay showed that miR-21 targeted the 3’-UTR of β-catenin and regulated the expression of β-catenin.Conclusions: miR-21 could enhance the proliferation and invasion abilities of osteosarcoma cell lines U2OS via upregulating theβ-catenin expression. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect ofhypoxia on the invasion ability ofretinoblastoma cell and its underlying mechanism. Methods: HXO-RB44 cells were cultured under normoxia (21%O O2) and hypoxia(1%O O2) conditions for 24 hours. The effect of hypoxia on invasion ability of HXO-RB44 cells were monitored with transwell invasion assay; the mRNA and protein expression levels of HIF-1a and MMP9 were detected by RT-PCR and western blot; luciferase assay was performed to assess the HIF-1a regulation by hypoxia, and MMP9 regulation by HIF-1a. Furthermore, HIF-1a and MMP9 siRNA was used to investigate the effect of HIF-1a/MMP9 signaling on hypoxia induced cell invasion. Results: The invaded cell number，mRNA and protein expression of HIF-1a and MMP9 in hypoxia group were higher than those in the normoxia group (P<0.05). The activity of MMP9 in HIF-1a overexpression group was higher than that of the vector group (P<0.05). Compared with the normoxia group，the activity ofHIF-1a in hypoxia group was significantly elevated (P< 0.05). Compared with negative control group，the mRNA and protein expression of HIF-1a and MMP9 in HIF-1a siRNA group were re¬markedly decreased (P<0.05)，whereas the mRNA and protein expression of HIF-1a in MMP9 siRNA group didn't change. The invaded cells in HIF-1a siRNA group and MMP9 siRNA group were significantly decreased (P<0.05). Conclusion: Hypoxia promotes the inva¬sion ofretinoblastoma cell line HXO-RB44 and the activation ofHIF-1a/MMP9 signaling pathway is involved in this process. [ABSTRACT FROM AUTHOR]

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Objective: To investigate the effect of dexmedetomidine on the hemodynamics and neurocognitive function of patients undergoing abdominal surgery with combined anesthesia. Methods: 172 cases of patients undergoing abdominal surgery were selected in our hospital from September 2016 to September 2017, the patients were divided into the experimental group(n=90) and the control group(n=82) according to the principle of random distribution. The changes of arterial pressure, heart rate, serum tumor necrosis factor alpha(TNF-α), interleukin 6(IL-6) and calcium granulin beta(S100 beta) before and after extubation and the occurrence of extubation time and agitation were compared between two groups. The neurocognitive function of the two groups was evaluated and compared by the Mini Mental State Scale(MMSE) score at 24 hours after operation. Results: The mean arterial pressure, heart rate, serum TNF-alpha and IL-6 water of experimental group before extubation, extubation and at 2 hours after extubation were significantly lower than those in the control group(P<0.05). The extubation time and the incidence of restlessness were(11.07±2.82) min and 5.55%, respectively, which were significantly lower than those in the control group(P<0.05). At 24 hours after operation, the serum S100 beta protein level of the test group was(1.32±0.56) μg/L, obviously lower than that of the control group, and the MMSE score was(28.35±2.14) scores, which was significantly higher than that of the control group(P<0.05). Conclusion: Dexmedetomidine should be used in patients with abdominal surgery for complex anesthesia, which could more effectively stabilize the hemodynamics, relieve the inflammation, reduce the agitation and protect the neurocognitive function of the patients. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of β-catenin siRNA on the proliferation and apoptosis of keloid fibroblast cell. Methods: Real-time PCR and Western blot were performed to monitor the mRNA and protein expression of β-catenin in pathological scar tissue and adjacent normal tissue. Keloid fibroblast cell in vitro were transfected with 3 pairs of specific β-catenin small interfering RNA (siRNA), then Real-time PCR and Western blot were performed to identify the best siRNA. The proliferation and apoptosis of KFB transfected with β-catenin siRNA were detected by using MTT assay and flow cytometry. Results: The RT-PCR and Western blot assay results showed that the expression of β-catenin mRNA and protein in pathological scar tissue were significantly higher than those in the adjacent normal tissue (P< 0.05). The (3-catenin siRNA 2 remarkably inhibited the expression of β-catenin at mRNA and proteins in the Fiuman keloid fibroblasts. Compared with the control group, cell proliferation was decreased and apoptotic rate were increased in β-catenin siRNA 2 group. Conclusion: Knockdown of β-catenin significantly decreased the proliferation and increased the apoptosis of KFB, which could inhibit the formation of pathological scar. [ABSTRACT FROM AUTHOR]

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Objective: To evaluate the safety and effects of ultrasound-guided percutaneous catheter drainage (PCD) in the treatment of severe acute pancreatitis (SAP). Methods: The clinical data of 273 cases of SAP patients undergoing ultrasound-guided percutaneous catheter drainage treatment from January 2011 to December 2015 were retrospectively analyzed. The levels of peripheral blood white blood cells (WBC), IL-6, C-reactive protein (CRP), serum TNF-α before and after the drainage were compared between two groups. Results: Ultrasound-guided percutaneous catheter drainage was performed on all 273 patients. 131 patients were cured by ultrasound-guided percutaneous catheter drainage only and the systemic symptom of 103 patients were improved significantly and they were cured by the following-up retroperitoneal endoscopic necrosectomy. While progression of disease was found in 39 patients, they were directly converted to open operation finally. All the patients were performed successfully. Two patients died after the following-up retroperitoneal endoscopic necrosectomy. 13 patients of the open operation were died. After drainaging, the levels of peripheral blood white blood cells (WBC), IL-6, C-reactive protein (CRP) and serum TNF-α dropped dramatically compared with those before the drainage(P<0.05). Conclusions: Ultrasound-guided percutaneous catheter drainage was an effective method with less trauma and precious positioning for SAP. With successful Ultrasound-guided percutaneous catheter drainage, patients could be free from operation or create an ideal surrounding for the following-up treatment. [ABSTRACT FROM AUTHOR]

Obejective: To study comparison and analysis on emergency closed and open reduction with cannulated screws fixation in femoral neck fractures. Methods: 92 cases with femoral neck fractures from June 2015 to June 2016 period in our hospital were researched, according to the random number table they were divided into observation group (n=46) and control group (n=46). Observation group were treated by open reduction and cannulated screws, control group were used closed reduction and cannulated screws. Two groups of patients with intraoperative, postoperative follow-up situation, Harris hip function score and related complications were compared. Results: Observation group of patients required for operation time, intraoperative blood loss, wound length significantly more than the control group[(61.43± 5.34)min, (30.54± 4.27)mL, (6.43± 0.56)cm VS (46.54± 3.26)min, (16.43 ± 2.43)mL, (1.83± 0.44)cm] (P<0.05). Function Harris hip score of observation group was significantly higher than the control group [82.61% (38/46) VS 50.00%(23/46)](P<0.05). Two groups of patients with fracture healing rate had no significant difference (P>0.05), observation group of femoral head necrosis rate was significantly lower than the control group [2.17% (1/46) VS 13.04% (6/46)](P<0.05).Conclusions: Application of open reduction and hollow nail in the treatment of patients with femoral neck fracture method has more advantages, it has better clinical effects and lower incidence rate of ischemic necrosis in femoral head. [ABSTRACT FROM AUTHOR]

Objective: In order to study the influence of TLR4, plasma inflammatory cytokines and interleukins on acute pancreatitis patients bicontinuous blood purification treatment combined with ulinastatin. Methods: From January 2014 to 2016 January, 72 cases of patients who with acute pancreatitis admitted to our hospital, and it was randomly divided into observation group and control group, each of 36 cases. In the control group based on the foundation treatment with ulinastatin treatment, while the observation group in the control group therapy based on the use of continuous blood purification treatment. Recorded after treatment, APACHE II score, hospitalization time, abdominal pain disappearing time, serum amylase recovery time, were measured the level of before treatment and after a week of treatment of TLR4, plasma inflammatory factors and interleukin. Results: (1) Observation group after treatment APACHE II score, length of stay, abdominal pain disappeared time, serum amylase recovery time were significantly lower than or less than the control group (P＜0.05). (2)The levels of TLR4, CRP, IL-6 and TNF-α in the two groups after treatment were significantly lower than those before treatment (p＜0.05);The levels ofTLR4, CRP, IL-6 and TNF-α in the observation group were significantly lower than those in the control group (p＜0.05) after one week treatment. (3)The cure rate (34.29％) and total effective rate (74.29％) in the observation group were significantly higher than that in the control group (14.29％) and total effective rate (48. 57％). Conclusion: Compared to the single use of ulinastatin and continuous blood purification treatment combined with ulinastatin on the treatment of patients with acute pancreatitis effect significantly, can reduce the inflammatory reaction and the TLR4, plasma inflammatory factor and interleukin inflammatory factors. [ABSTRACT FROM AUTHOR]

The medical rescue practice teaching is an emergency medical rescue talent cultivation course for its simulating actual combat, and comprehensive interdisciplinary. According to the problems exposed by previous exercises, for example, students can't fully participate in the training, trainees for emergency response capacity is weak, the training set is not reasonable, and the inspection way can't reflect the real training situation of the students, we carried on the teaching mode reform. Using multipurpose learning modules, full participation of practice subjects of students. Integration of classroom, clinically relevant knowledge skills, organization of teaching training unit, establishing standardized treatment process, reducing irrelevant contents, the course can be finished in a short period of training with a high quality. Finally, the training quality can be ensured through the examination reform. [ABSTRACT FROM AUTHOR]

Undoubtedly, pathological findings is the golden standard for diagnosing prostate cancer. As we all know, targeted prostate biopsy under the guidance of image-guiding is the most efficient and the most convenient. Nevertheless,based on prostate specific antigen (PSA) screening and sextant biopsy, has been criticized for both overdiagnosis of low-grade tumors and underdiagnosis of clinically significant prostate cancers (Gleason score ≥7). So on viewing vertically of both national and abroad, image guidance has been added to perform targeted biopsies of lesions detected on multi-parametric magnetic resonance imaging (mpMRI) scans, including in-boreMRI-guided, cognitive fusion, andMRI/transrectal ultrasound fusion-guided biopsy. This review will examine advances in these image-guided targeted prostate biopsy techniques. [ABSTRACT FROM AUTHOR]

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Objective: To analyze the dynamic change of left ventricular longitudinal function in a rabbit model of myocardium ischemia-reperfusion with morphine preconditioning through strain rate imaging(SRI). Methods: A myocardiumischemia-reperfusion model was induced by occlusion and recanalization of coronary artery in forty male New Zealand white rabbits, which were randomly divided into the sham operated group (SH), morphine preconditioning ischemia reperfusion group (MF) and normal saline preconditioning ischemia reperfusion group (NS). Routine echocardiography datas and dynamic images were collected on 1 day before and within 28 days after the operation. All of these images were analyzed off-line using TDI software to survey the parameters, including the systolic velocity and systolic strain rate. Results: On the 1st day after operation, the global and regional systolic function of left ventricle of group MF and group NS were lower than those preoperation and in group SH (P<0.05), as time went, the above-mentioned parameters decreased gradually after ischemia reperfusion (P<0.05), which were more obviously in group NS (P<0.05). Conclusions: It was objective and accurate to detect the variance of regional myocardial function in myocardial ischemia reperfusion injury using strain rate imaging. Strain rate imaging becomes a reliable and non-invasive method of evaluating myocardial function in clinic. Morphine preconditioning could apparently attenuate the myocardial ischemia reperfusion injury in rabbits. [ABSTRACT FROM AUTHOR]

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Glioma is the most common primary brain tumors in adults. The effectiveness of systemic chemotherapy and surgery are limited. The chemotherapy drug can not penetrate the blood-brain barrier effectively. The nanoparticle has emerged as a potential vector for brain delivery, which is able to overcome the difficulties of modern strategies and keep the stability of chemotherapy drug as well as prolong the blood circulation time. However, many problems of nanoparticles are still needed to be solved in the treatment of glioma, for example, the presence of the blood-brain barrier (BBB) limits the passage of a wide variety of nanoparticles. Moreover, the precision of targeting treatment is limited. This review reports the latest research in nanoparticle-based glioma treatment, and discuss how to solve the present problems. It focuses on the strategy of presence of the blood-brain barrier and the precision of targeted treatment. [ABSTRACT FROM AUTHOR]

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Objective: To investigate the clinical efficacy and safety of ulinastatin in treatment of different types of acute pancreatitis. Methods: 84 cases of patients with acute pancreatitis admitted in our hospital from January 2013 to January 2014 were selected and randomly divided into the observation group and control group. Both groups received conventional treatment, the control group received octreotide treatment, observation group received ulinastatin on the basis of the control group, the clinical efficacy, serum IL-6 and TNF-α levels before and after treatment, the occurrence of adverse reactions of two groups were compared. Results: The total effective rate of observation group was 96.72%, which was significantly higher than that of the control group(85.71%); no significant difference was found in the efficacy of acute edematous pancreatitis(AEP) betwen the two groups(P<0.05), but the efficiency of acute hemorrhagic necrotizing pancreatitis(AHNP) in the observation group was significantly higher than that of the control group(P<0.05).After treatment, the serum IL-6 and TNF-α levels of both groups were significantly lower than those before treatment(P<0.05), and the serum IL-6 and TNF-α levels of observation group were significantly lower than those of the control group(P<0.05), the serum IL-6 and TNF- α levels of patients with AEP were significantly lower than those with AHNP(P<0.05). There was no significant difference or drug-related adverse reactions in the liver and kidney dysfunction between two groups. Conclusions: Ulinastatin could significantly lower the levels of inflammatory factors in the treatment of AEP and AHNP and had significant clinical effect on the AEP, it should be widely applied in clinic. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the application of laser doppler in assessing microvascular vasomotion of STZ-induced diabetic mice. Methods: 20 BALB/c mice were randomly divided into diabetic group(n=10) and control group(n=10). Diabetic mice were induced with 40 mg/kg STZ for 5 consecutive days. Cutaneous blood perfusion was determined by Moor LDLS, while pancreatic blood perfusion and micro-vessels vasomotion were detected by Moor VMS. Results: Compared with control group, the cutaneous blood perfusion and total flux(P=0.009) was decreased, and the frequency and amplitude of vasomotion of pancreatic micro-vessels was also decreased in diabetic mice(P<0.001, P<0.001, respectively). Conclusion: Combined Moor LDLS and Moor VMS-LDF might be an applicable method to evaluate microvascular vasomotion of diabetic mice. [ABSTRACT FROM AUTHOR]

The healing of chronic skin wound, a complicated but orderly pathophysiolological process involved many factors such as inflammatory cell and cytokin and related to issue repair, regeneration and reconstruction, is still an important and hot spot in clinic research. With the development of molecular biology, we have a futher understanding about the mechanism of the wound healing.Wnt signaling pathway is a highly conserved pathway consisted of Wnt protein, receptor and regulatory protein, and participate in many process such as cell proliferation, apoptosis, differentiation. As a pathway involved in wound healing, Wnt signaling is considered to regulate and induce the development of skin, appendage and follicles, promote the angiogenesis of wound and epithelia remodeling. By reviewing the literature, we try to reveal the relationship between Wnt signaling pathway and skin wound healing from inflammatory cells, fibroblasts, stem cell, angiogenesis, epidermis and hair follicle regeneration and so on. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To study the clinical efficacy of clotrimazole vaginal tablets combined with nifuratel nysfungin vaginal soft capsules and lactobacillus capsule in the treatment of candida vaginitis, and to provide the basis for clinical treatment. Methods: A total of 60 patients with candida vaginitis, who were treated in the Third Affiliated Hospital of Guangzhou Medical University from September2014 to June 2015, were selected and randomly divided into experimental group(n=30) and control group(n=30). The experimental group was treated with clotrimazole vaginal tablets, nifuratel nysfungin vaginal soft capsules and lactobacillus capsule, while the control group,clotrimazole vaginal tablets and lactobacillus capsule. The distribution of pathogenic bacteria of all the patients was detected. After treatment, all the patients were followed up for three months; the clinical efficacy and adverse reactions of the two groups were analyzed.Re sults: The bacterial culture results showed that 158 strains of candida were separated, in which, candida albicans was the most, accounting for 66.46%. The total effective rate(93.33%) of the experimental group was significantly higher than that(76.67%) of the control group, the difference was statistically significant(P<0.05). There was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Combination of clotrimazole vaginal tablets, nifuratel nysfungin vaginal soft capsules with lactobacillus capsule has a good clinical efficacy in the treatment of patients with candida vaginitis, without obvious adverse reactions. [ABSTRACT FROM AUTHOR]

Objective: To investigate the application and evaluation of microlecture plus flipped classroom in physiology experiment teaching. Methods: A total of 84 medical students of five-year program from the Fourth Military Medical University were chosen as objects of analysis. They were randomly divided into control group (Calss A, 42), in which students were divided into 7 groups (6/group) and practiced with traditional teaching model and experimental group, in which the students were divided into 7 groups (6/group) and practiced with microlecture plus flipped classroom teaching model. After the end of the course, examination papers were tested, and the scores of the exam were analyzed. At the same time, the effects of teaching were evaluated according to the questionnaire survey. Results: The essay scores of class B were significantly higher than those of class A (P<0.05). The results revealed that the microlecture plus flipped classroom teaching model was superior to traditional teaching model. The microlecture plus flipped classroom in physiology experiment teaching was obviously better than traditional teaching model in improving students’ interests in practice learning and abilities such as independent thinking and problem-solving, team cooperation, and independent learning ability. Conclusions: The microlecture plus flipped classroom in physiology experiment teaching model not only deepen the understanding of theoretical knowledge and improve students a variety of skills, but also should be applied to the other experimental courses. [ABSTRACT FROM AUTHOR]

Objective: To compare the change of hepatic and renal function after open or robotic laparoscopic gynecologic surgery. Methods: Patients scheduled for open or robotic laparoscopic gynecologic surgery were involved in this study (n=20). Inclusion criteria included age between 18-30 yr, BMI between 18-30 kg/cm2 and ASA status 1-2. Anesthesia induction was done with propofol （1.5-2 mg/kg）and fentanyl （2-4 µg/kg）. Anesthesia was maintained by sevoflurane and remifentanil. Narcotrend index was maintained at 40-60 during surgery. Venous blood sample was collected before and at 30min after surgery for assay of Alanine transaminase (ALT), Aspartate transaminase (AST), Blood urea nitrogen (BUN) and Creatinine (Cr). Results: Compared with patients undergoing open surgery, those undergoing robotic laparoscopic gynecologic surgery showed significant change of ALT, AST, BUN and Cr. Conclusion: Long duration of pneumoperitoneum during robotic laparoscopic gynecologic surgery could lead to abnormal hepatic and renal function. However, the clinical significance of this change is still unclear. [ABSTRACT FROM AUTHOR]