1. [Hyperlipidemia as a factor in the development and progress of diabetic nephropathy].
- Author
-
Shestakova MV, Dedov II, Neverov NI, Severgina ES, Diuzhev TG, and Ponomarev AB
- Subjects
- Adolescent, Adult, Albuminuria blood, Biopsy, Cholesterol blood, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 1 pathology, Diabetic Nephropathies etiology, Diabetic Nephropathies pathology, Female, Humans, Hyperlipidemias pathology, Kidney pathology, Male, Middle Aged, Prognosis, Triglycerides blood, Diabetes Mellitus, Type 1 blood, Diabetic Nephropathies blood, Hyperlipidemias complications
- Abstract
Twenty-nine patients with insulin-dependent diabetes mellitus with similarly manifest renal involvement were examined to elucidate the role of dyslipidemia in diabetic nephropathy progress. Clinico-laboratory parameters (urinary albumin excretion, blood serum levels of total cholesterol, triglycerides, low, very low, and high density lipoprotein cholesterol) and morphologic changes in renal tissue biopsy specimens were analyzed. An increment of the number of large lipid incorporations was observed in various cells of renal glomeruli and interstitium, as well as a high prevalence of low density lipoprotein deposition in glomerular basal membranes and canaliculi as the renal process augmented in severity. Since lipids accumulating in glomerular structures may stimulate mesangial cell proliferation and mesangial matrix hyperproduction, the authors believe that dyslipidemia in diabetes mellitus may be conducive to a more rapid progress of renal disease.
- Published
- 1993