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[Hyperlipidemia as a factor in the development and progress of diabetic nephropathy].
- Source :
-
Problemy endokrinologii [Probl Endokrinol (Mosk)] 1993 Sep-Oct; Vol. 39 (5), pp. 7-9. - Publication Year :
- 1993
-
Abstract
- Twenty-nine patients with insulin-dependent diabetes mellitus with similarly manifest renal involvement were examined to elucidate the role of dyslipidemia in diabetic nephropathy progress. Clinico-laboratory parameters (urinary albumin excretion, blood serum levels of total cholesterol, triglycerides, low, very low, and high density lipoprotein cholesterol) and morphologic changes in renal tissue biopsy specimens were analyzed. An increment of the number of large lipid incorporations was observed in various cells of renal glomeruli and interstitium, as well as a high prevalence of low density lipoprotein deposition in glomerular basal membranes and canaliculi as the renal process augmented in severity. Since lipids accumulating in glomerular structures may stimulate mesangial cell proliferation and mesangial matrix hyperproduction, the authors believe that dyslipidemia in diabetes mellitus may be conducive to a more rapid progress of renal disease.
- Subjects :
- Adolescent
Adult
Albuminuria blood
Biopsy
Cholesterol blood
Diabetes Mellitus, Type 1 complications
Diabetes Mellitus, Type 1 pathology
Diabetic Nephropathies etiology
Diabetic Nephropathies pathology
Female
Humans
Hyperlipidemias pathology
Kidney pathology
Male
Middle Aged
Prognosis
Triglycerides blood
Diabetes Mellitus, Type 1 blood
Diabetic Nephropathies blood
Hyperlipidemias complications
Subjects
Details
- Language :
- Russian
- ISSN :
- 0375-9660
- Volume :
- 39
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Problemy endokrinologii
- Publication Type :
- Academic Journal
- Accession number :
- 8108357