7 results on '"Vabret, Astrid"'
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2. Sequencing and analysis of globally obtained human parainfluenza viruses 1 and 3 genomes
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Bose, Michael E., primary, Shrivastava, Susmita, additional, He, Jie, additional, Nelson, Martha I., additional, Bera, Jayati, additional, Fedorova, Nadia, additional, Halpin, Rebecca, additional, Town, Christopher D., additional, Lorenzi, Hernan A., additional, Amedeo, Paolo, additional, Gupta, Neha, additional, Noyola, Daniel E., additional, Videla, Cristina, additional, Kok, Tuckweng, additional, Buys, Amelia, additional, Venter, Marietjie, additional, Vabret, Astrid, additional, Cordey, Samuel, additional, and Henrickson, Kelly J., additional
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- 2019
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3. Evaluation of Four Commercial Multiplex Molecular Tests for the Diagnosis of Acute Respiratory Infections
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Salez, Nicolas, Vabret, Astrid, Leruez-Ville, Marianne, Andreoletti, Laurent, Carrat, Fabrice, Renois, Fanny, de Lamballerie, Xavier, Emergence des Pathologies Virales (EPV), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Virologie Humaine et Moléculaire [Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Infections à Vih, Réservoirs, Pharmacologie des Antirétroviraux et Prévention de la Transmission Mère Enfant, Université Paris Descartes - Paris 5 (UPD5), Laboratoire de Virologie, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire de Virologie Médicale et Moléculaire - EA 4684 (CardioVir), Université de Reims Champagne-Ardenne (URCA)-Centre Hospitalier Universitaire de Reims (CHU Reims)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA), ESIM - Déterminants Sociaux de la Santé et du Recours aux Soins (DS3), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Emergence des Pathologies Virales ( EPV ), Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Assistance Publique - Hôpitaux de Marseille ( APHM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratory of Human and Molecular Virology, IFR146 ICORE, Université Paris Descartes - Paris 5 ( UPD5 ), Laboratoire de Virologie Médicale et Moléculaire ( CardioVir ), Université de Reims Champagne-Ardenne ( URCA ) -Centre Hospitalier Universitaire de Reims ( CHU Reims ) -SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ) -Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ), Epidémiologie, Systèmes dínformation et modélisation ( ESIM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Unité de Santé Publique, Assistance publique - Hôpitaux de Paris - AP-HP (FRANCE)-CHU Saint-Antoine [APHP], Institut Hospitalier Universitaire Méditerranée Infection ( IHU AMU ), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV), HAL AMU, Administrateur, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)
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Rhinovirus ,[SDV]Life Sciences [q-bio] ,lcsh:Medicine ,Cytomegalovirus ,Parechovirus ,medicine.disease_cause ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Human bocavirus ,Influenza A virus ,Medicine ,Multiplex ,Respiratory system ,REAL-TIME PCR ,lcsh:Science ,Child ,Respiratory Tract Infections ,Enterovirus ,Multidisciplinary ,Respiratory pathogen ,Middle Aged ,University hospital ,Orthomyxoviridae ,3. Good health ,Respiratory Syncytial Viruses ,[SDV] Life Sciences [q-bio] ,[ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Child, Preschool ,Acute Disease ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,ACID AMPLIFICATION TESTS ,Research Article ,Adult ,Adolescent ,FILMARRAY RP ,Gram-Positive Bacteria ,Respirovirus ,Adenoviridae ,XTAG RVP ,VIRUS DETECTION ,Gram-Negative Bacteria ,[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology ,Humans ,In patient ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology ,VIRAL PANEL ASSAY ,Aged ,PATHOGENS ,[ SDV ] Life Sciences [q-bio] ,business.industry ,lcsh:R ,Infant ,Influenza a ,PERFORMANCE ,Virology ,Coronavirus ,lcsh:Q ,Reagent Kits, Diagnostic ,Disease progress ,business ,Multiplex Polymerase Chain Reaction - Abstract
International audience; Acute Respiratory Infections (ARIs) are responsible for considerable morbidity and mortality worldwide. Documentation of respiratory specimens can help for an appropriate clinical management with a significant effect on the disease progress in patient, the antimicrobial therapy used and the risk of secondary spread of infection. Here, we compared the performances of four commercial multiplex kits used in French University Hospital diagnostic microbiology laboratories for the detection of ARI pathogens (i.e., the xTAG Respiratory Viral Panel Fast, RespiFinder SMART 22, CLART PneumoVir and Fast Track Diagnostics Respiratory Pathogen 33 kits). We used a standardised nucleic acids extraction protocol and a comprehensive comparative approach that mixed reference to well established real-time PCR detection techniques and analysis of convergent positive results. We tested 166 respiratory clinical samples and identified a global high degree of correlation for at least three of the techniques (xTAG, RespiFinder and FTD33). For these techniques, the highest Youden's index (YI), positive predictive (PPV) and specificity (Sp) values were observed for Core tests (e.g., influenza A [YI:0.86-1.00; PPV:78.95-100.00; Sp:97.32-100.00] & B [YI:0.44-1.00; PPV:100.00; Sp:100.00], hRSV [YI:0.50-0.99; PPV:85.71-100.00; Sp:99.38-100.00], hMPV [YI:0.71-1.00; PPV:83.33-100.00; Sp:99.37-100.00], EV/hRV [YI:0.62-0.82; PPV:93.33-100.00; Sp:94.48-100.00], AdV [YI:1.00; PPV:100.00; Sp:100.00] and hBoV [YI:0.20-0.80; PPV:57.14-100.00; Sp:98.14-100.00]). The present study completed an overview of the multiplex techniques available for the diagnosis of acute respiratory infections.
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- 2015
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4. Viral Etiology of Respiratory Tract Infections in Children at the Pediatric Hospital in Ouagadougou (Burkina Faso)
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Ouédraogo, Solange, primary, Traoré, Blaise, additional, Nene Bi, Zah Ange Brice, additional, Yonli, Firmin Tiandama, additional, Kima, Donatien, additional, Bonané, Pierre, additional, Congo, Lassané, additional, Traoré, Rasmata Ouédraogo, additional, Yé, Diarra, additional, Marguet, Christophe, additional, Plantier, Jean-Christophe, additional, Vabret, Astrid, additional, and Gueudin, Marie, additional
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- 2014
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5. Comparative Evaluation of Six Commercialized Multiplex PCR Kits for the Diagnosis of Respiratory Infections
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Pillet, Sylvie, primary, Lardeux, Marina, additional, Dina, Julia, additional, Grattard, Florence, additional, Verhoeven, Paul, additional, Le Goff, Jérôme, additional, Vabret, Astrid, additional, and Pozzetto, Bruno, additional
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- 2013
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6. In Very Young Infants Severity of Acute Bronchiolitis Depends On Carried Viruses
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Marguet, Christophe, primary, Lubrano, Marc, additional, Gueudin, Marie, additional, Le Roux, Pascal, additional, Deschildre, Antoine, additional, Forget, Chantal, additional, Couderc, Laure, additional, Siret, Daniel, additional, Donnou, Marie-Dominique, additional, Bubenheim, Michael, additional, Vabret, Astrid, additional, and Freymuth, François, additional
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- 2009
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7. Plasma nevirapine concentrations predict virological and adherence failure in Kenyan HIV-1 infected patients with extensive antiretroviral treatment exposure.
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Kimulwo, Maureen J., Okendo, Javan, Aman, Rashid A., Ogutu, Bernhards R., Kokwaro, Gilbert O., Ochieng, Dorothy J., Muigai, Anne W. T., Oloo, Florence A., and Ochieng, Washingtone
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HIV-positive persons ,NEVIRAPINE ,VIROLOGY ,ANTIRETROVIRAL agents ,PREVENTIVE medicine ,THERAPEUTICS - Abstract
Treatment failure is a key challenge in the management of HIV-1 infection. We conducted a mixed-model survey of plasma nevirapine (NVP) concentrations (cNVP) and viral load in order to examine associations with treatment and adherence outcomes among Kenyan patients on prolonged antiretroviral therapy (ART). Blood plasma was collected at 1, 4 and 24 hours post-ART dosing from 58 subjects receiving NVP-containing ART and used to determine cNVP and viral load (VL). Median duration of treatment was 42 (range, 12–156) months, and 25 (43.1%) of the patients had virologic failure (VF). cNVP was significantly lower for VF than non- VF at 1hr (mean, 2,111ng/ml vs. 3,432ng/ml, p = 0.003) and at 4hr (mean 1,625ng/ml vs. 3,999ng/ml, p = 0.001) but not at 24hr post-ART dosing. Up to 53.4%, 24.1% and 22.4% of the subjects had good, fair and poor adherence respectively. cNVP levels peaked and were > = 3μg.ml at 4 hours in a majority of patients with good adherence and those without VF. Using a threshold of 3μg/ml for optimal therapeutic nevirapine level, 74% (43/58), 65.5% (38/58) and 86% (50/58) of all patients had sub-therapeutic cNVP at 1, 4 and 24 hours respectively. cNVP at 4 hours was associated with adherence (p = 0.05) and virologic VF (p = 0.002) in a chi-square test. These mean cNVP levels differed significantly in non-parametric tests between adherence categories at 1hr (p = 0.005) and 4hrs (p = 0.01) and between ART regimen categories at 1hr (p = 0.004) and 4hrs (p<0.0001). Moreover, cNVP levels correlated inversely with VL (p< = 0.006) and positively with adherence behavior. In multivariate tests, increased early peak NVP (cNVP4) was independently predictive of lower VL (p = 0.002), while delayed high NVP peak (cNVP24) was consistent with increased VL (p = 0.033). These data strongly assert the need to integrate plasma concentrations of NVP and that of other ART drugs into routine ART management of HIV-1 patients. [ABSTRACT FROM AUTHOR]
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- 2017
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