1. Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study.
- Author
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Ming-ming Guo, Xue-ning Duan, Shu-de Cui, Fu-guo Tian, Xu-chen Cao, Cui-zhi Geng, Zhi-min Fan, Xiang Wang, Shu Wang, Hong-chuan Jiang, Jian-guo Zhang, Feng Jin, Jin-hai Tang, Hong Liang, Zhen-lin Yang, Hai-bo Wang, Qi-tang Wang, Guo-lou Li, Liang Li, Shi-guang Zhu, Wen-shu Zuo, Li-yuan Liu, Lu Wang, Dan-dan Ma, Shu-chen Liu, Yu-juan Xiang, Lu Liu, Chun-miao Ye, Wen-zhong Zhou, Fei Wang, Li-xiang Yu, Zhong-bing Ma, and Zhi-gang Yu
- Subjects
Medicine ,Science - Abstract
The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer (P=0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk (P=0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer (P=0.028) in the subgroup of BMI=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed.
- Published
- 2015
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