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Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study
- Source :
- PLoS ONE, PLoS ONE, Vol 10, Iss 6, p e0129246 (2015)
- Publication Year :
- 2015
- Publisher :
- Public Library of Science (PLoS), 2015.
-
Abstract
- The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer (P=0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk (P=0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer (P=0.028) in the subgroup of BMI=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed.
- Subjects :
- Adult
Risk
China
medicine.medical_specialty
lcsh:Medicine
Breast Neoplasms
Breast cancer
Diabetes mellitus
Internal medicine
medicine
Humans
Risk factor
Family history
lcsh:Science
skin and connective tissue diseases
Aged
Multidisciplinary
Adiponectin
business.industry
lcsh:R
Case-control study
nutritional and metabolic diseases
Middle Aged
Prognosis
medicine.disease
Molecular Weight
Menopause
Endocrinology
Case-Control Studies
lcsh:Q
Female
business
Body mass index
hormones, hormone substitutes, and hormone antagonists
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....57f31575d9774fe33e950a2281a95824