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2 results on '"Demet TEKİN"'

1. Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach.

Author

Yvonne J K Edwards, Gary W Beecham, William K Scott, Sawsan Khuri, Guney Bademci, Demet Tekin, Eden R Martin, Zhijie Jiang, Deborah C Mash, Jarlath ffrench-Mullen, Margaret A Pericak-Vance, Nicholas Tsinoremas, and Jeffery M Vance

Subjects
Medicine, Science
Abstract

Parkinson's disease (PD) has had six genome-wide association studies (GWAS) conducted as well as several gene expression studies. However, only variants in MAPT and SNCA have been consistently replicated. To improve the utility of these approaches, we applied pathway analyses integrating both GWAS and gene expression. The top 5000 SNPs (p

Published
2011
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2. Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach

Author

Nicholas F. Tsinoremas, Margaret A. Pericak-Vance, Guney Bademci, Demet Tekin, Jarlath Ffrench-Mullen, Jeffery M. Vance, Zhijie Jiang, Eden R. Martin, Deborah C. Mash, William K. Scott, Gary W. Beecham, Sawsan Khuri, and Yvonne J. K. Edwards

Subjects
Gene regulatory network, Gene Identification and Analysis, lcsh:Medicine, Gene Expression, Genome-wide association study, Gene Regulatory Networks, lcsh:Science, Genetics, Multidisciplinary, Systems Biology, Statistics, Chromosome Mapping, Parkinson Disease, Genomics, Neurology, Meta-analysis, Medicine, Metabolic Networks and Pathways, Signal Transduction, Research Article, Consensus, MAP Kinase Signaling System, Clinical Research Design, Systems biology, Single-nucleotide polymorphism, Biology, Biostatistics, Models, Biological, Polymorphism, Single Nucleotide, Signaling Pathways, Molecular Genetics, Gene mapping, Genome-Wide Association Studies, Humans, Genetic Predisposition to Disease, Genetic association, Computational Neuroscience, Motor Systems, Gene Expression Profiling, lcsh:R, Computational Biology, Human Genetics, Receptor Cross-Talk, Gene expression profiling, Systems Integration, lcsh:Q, Molecular Neuroscience, Meta-Analyses, Genome Expression Analysis, Mathematics, Genome-Wide Association Study, Neuroscience
Abstract

Parkinson's disease (PD) has had six genome-wide association studies (GWAS) conducted as well as several gene expression studies. However, only variants in MAPT and SNCA have been consistently replicated. To improve the utility of these approaches, we applied pathway analyses integrating both GWAS and gene expression. The top 5000 SNPs (p

Published
2010

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