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Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach
- Source :
- PLoS ONE, PLoS ONE, Vol 6, Iss 2, p e16917 (2011)
- Publication Year :
- 2010
-
Abstract
- Parkinson's disease (PD) has had six genome-wide association studies (GWAS) conducted as well as several gene expression studies. However, only variants in MAPT and SNCA have been consistently replicated. To improve the utility of these approaches, we applied pathway analyses integrating both GWAS and gene expression. The top 5000 SNPs (p
- Subjects :
- Gene regulatory network
Gene Identification and Analysis
lcsh:Medicine
Gene Expression
Genome-wide association study
Gene Regulatory Networks
lcsh:Science
Genetics
Multidisciplinary
Systems Biology
Statistics
Chromosome Mapping
Parkinson Disease
Genomics
Neurology
Meta-analysis
Medicine
Metabolic Networks and Pathways
Signal Transduction
Research Article
Consensus
MAP Kinase Signaling System
Clinical Research Design
Systems biology
Single-nucleotide polymorphism
Biology
Biostatistics
Models, Biological
Polymorphism, Single Nucleotide
Signaling Pathways
Molecular Genetics
Gene mapping
Genome-Wide Association Studies
Humans
Genetic Predisposition to Disease
Genetic association
Computational Neuroscience
Motor Systems
Gene Expression Profiling
lcsh:R
Computational Biology
Human Genetics
Receptor Cross-Talk
Gene expression profiling
Systems Integration
lcsh:Q
Molecular Neuroscience
Meta-Analyses
Genome Expression Analysis
Mathematics
Genome-Wide Association Study
Neuroscience
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 6
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....d41500e02d074ac0380c08be86695d41