1. A web visualization tool using T cell subsets as the predictor to evaluate COVID-19 patient's severity
- Author
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Peng Peng, Feng Xu, Shinichi Tokuno, Ungil Chung, Xianxiang Chen, Xiaoyu Liu, Xiyong Dai, Qibin Liu, Xuemin Fang, and Bing Wang
- Subjects
Viral Diseases ,Epidemiology ,030204 cardiovascular system & hematology ,Logistic regression ,Severity of Illness Index ,Tertiary Care Centers ,White Blood Cells ,0302 clinical medicine ,Medical Conditions ,Animal Cells ,Risk Factors ,T-Lymphocyte Subsets ,Medicine and Health Sciences ,030212 general & internal medicine ,Lymphocytes ,Virus Testing ,Multidisciplinary ,T Cells ,Total Cell Counting ,Middle Aged ,Prognosis ,Patient Discharge ,medicine.anatomical_structure ,Infectious Diseases ,Medicine ,Cellular Types ,Coronavirus Infections ,Research Article ,Adult ,medicine.medical_specialty ,China ,Coronavirus disease 2019 (COVID-19) ,T cell ,Science ,Immune Cells ,Immunology ,Cell Enumeration Techniques ,Pneumonia, Viral ,COVID-19 ,Medical risk factors ,Virus testing ,T cells ,Total cell counting ,Geriatric care ,Research and Analysis Methods ,03 medical and health sciences ,Betacoronavirus ,Immune system ,Diagnostic Medicine ,Internal medicine ,Severity of illness ,medicine ,Humans ,Pandemics ,Aged ,Internet ,Blood Cells ,business.industry ,SARS-CoV-2 ,Biology and Life Sciences ,Covid 19 ,Cell Biology ,Web visualization ,Health Care ,Logistic Models ,Medical Risk Factors ,Mann–Whitney U test ,Geriatric Care ,business - Abstract
Wuhan, China was the epicenter of the 2019 coronavirus outbreak. As a designated hospital for COVID-19, Wuhan Pulmonary Hospital has received over 700 COVID-19 patients. With the COVID-19 becoming a pandemic all over the world, we aim to share our epidemiological and clinical findings with the global community. We studied 340 confirmed COVID-19 patients with clear clinical outcomes from Wuhan Pulmonary Hospital, including 310 discharged cases and 30 death cases. We analyzed their demographic, epidemiological, clinical and laboratory data and implemented our findings into an interactive, free access web application to evaluate COVID-19 patient’s severity level. Our results show that baseline T cell subsets results differed significantly between the discharged cases and the death cases in Mann Whitney U test: Total T cells (p < 0.001), Helper T cells (p
- Published
- 2020