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Quantitative assessment of Pulmonary Alveolar Proteinosis (PAP) with ultra-dose CT and correlation with Pulmonary Function Tests (PFTs)
- Source :
- PLoS ONE, Vol 12, Iss 3, p e0172958 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- Background The purpose of this study was to investigate whether ultra-low-dose chest computed tomography (CT) can be used for visual assessment of CT features in patients with pulmonary alveolar proteinosis (PAP) and to evaluate the relationship between the quantitative analysis of the ultra-low-dose CT scans and the pulmonary function tests (PFTs). Methods Thirty-eight patients (mean [SD] age, 44.47 [12.28] years; 29 males, 9 females) with PAP were enrolled and subjected to two scans each with low-dose CT (reference parameters: 120 kV and 50 mAs) and ultra-low-dose CT (reference parameters, 80 kV, 25 mAs). Images were reconstructed via filtered back projection (FBP) for low-dose CT and iterative reconstruction (IR) for ultra-low-dose CT. All patients underwent PFT. The Visual analysis for ground glass opacity (GGO) is performed. The quantitative CT and PFT results were analyzed by canonical correlations. Results The mean body mass index (BMI) was 25.37±3.26 kg/m2. The effective radiation doses were 2.30±0.46 and 0.24±0.05 mSv for low-dose and ultra-low-dose CT, respectively. The size-specific dose estimates were 5.81±0.81 and 0.62±0.09 mSv for low-dose and ultra-low-dose CT. GGOs and interlobular septal thickening were observed bilaterally in all patients. The average visual GGO score was lower in the upper field (2.67±1.24) but higher in the middle and lower fields (3.08±1.32 and 3.08±0.97, respectively). The average score for the whole lung was 2.94±1.19. There is a significant correlation between PFTs and quantitative of ultra-low-dose CT (canonical loading = 0.78). Conclusions Ultra-low-dose CT has the potential to quantify the lung parenchyma changes of PAP. This technique could provide a sensitive and objective assessment of PAP and has good relation with PFTs. In addition, the radiation dose of ultra-low-dose CT was very low.
- Subjects :
- Male
Pulmonology
Physiology
medicine.medical_treatment
Cancer Treatment
Pulmonary Function
lcsh:Medicine
Pathology and Laboratory Medicine
Ground-glass opacity
Diagnostic Radiology
Body Mass Index
030218 nuclear medicine & medical imaging
Pulmonary function testing
Correlation
0302 clinical medicine
Medicine and Health Sciences
Prospective Studies
Prospective cohort study
lcsh:Science
Tomography
Optical Properties
Multidisciplinary
Infrared Radiation
Radiology and Imaging
Physics
Electromagnetic Radiation
Middle Aged
Pulmonary Imaging
Respiratory Function Tests
medicine.anatomical_structure
Physiological Parameters
Oncology
030220 oncology & carcinogenesis
Physical Sciences
Female
medicine.symptom
Pulmonary alveolar proteinosis
Research Article
Adult
Opacity
Clinical Oncology
Imaging Techniques
Materials Science
Material Properties
Radiation Therapy
Neuroimaging
Pulmonary Alveolar Proteinosis
Research and Analysis Methods
Young Adult
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
medicine
Humans
Lung
business.industry
Body Weight
lcsh:R
Biology and Life Sciences
Dose-Response Relationship, Radiation
medicine.disease
Computed Axial Tomography
Radiation therapy
Lesions
lcsh:Q
Clinical Medicine
Tomography, X-Ray Computed
business
Nuclear medicine
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....8e11ec6a94362dab144cac6db9ed6f96